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COVID-19
Clinical Presentations and Lessons
Learned from the Front Lines
May 13, 2020
CME Credit
• Bridgeport Hospital Yale New Haven Health is accredited by the Connecticut State
Medical Society to sponsor continuing medical education for physicians. The
Bridgeport Hospital Yale New Haven Health designates this live activity for a
maximum of one (1) AMA PRA Category 1 CreditsTM. Physicians should claim only
credits commensurate with the extent of their participation in the various
activities.
• This activity has been planned and implemented in accordance with the Essential
Areas and policies of the Accreditation Council for Continuing Medical Education
through the joint sponsorship of Bridgeport Hospital Yale New Haven Health and
the Weitzman Institute. Bridgeport Hospital Yale New Haven Health is accredited
by the Connecticut State Medical Society to provide continuing medical education
for physicians.
• The content of this activity is not related to products or services of an ACCME-
defined commercial interest; therefore, no one in control of content has a relevant
financial relationship to disclose and there is no potential for conflicts of interest.
Weitzman ECHO COVID-19: Clinical Presentations and Lessons Learned from the Front Lines
Objectives
- Update on epidemiology (SARS-CoV-2,
COVID-19)
- Review any good news?
- Continue team efforts to fight the virus
COVID-19 in the United States
1,367,491 cases on 5/12/20 – up from 1,203,673 cases last week (5/5/20) -
https://coronavirus.jhu.edu/map.html
Any good news?
• Remdesivir:
–Gilead to allow wide-spread generic
development
• Continuing the fight:
–10,000th COVID-19
discharge
Weitzman ECHO COVID-19: Clinical Presentations and Lessons Learned from the Front Lines
Stay safe -- Stay up to date
• https://www.cdc.gov/coronavirus/2019-
ncov/index.html
https://emergency.cdc.gov/coca/calls/2020/
• https://www.who.int/emergencies/disea
ses/novel-coronavirus-2019
• https://covidactnow.org/
• https://coronavirus.jhu.edu/map.html
COVID-19:
Clinical Presentations and Lessons
Learned from the Front Lines
Joseph Masci, MD
Chairman of Global Health, Elmhurst Hospital Center
Professor of Medicine, Infectious Disease
&
Emma Kaplan-Lewis, MD
HIV Clinical Quality Director, NYC Health and Hospitals
Assistant Professor of Medicine, Infectious Disease
Outline
• Unexpected Findings
• Demographics of COVID-19 in NYC
• Indicators used to inform policy (ie.
Social distancing)
• Clinical takeaways
Unexpected Findings
• Pulmonary disease
• Renal disease
• Heart disease
• Liver disease
• Hypercoagulable
state
• Strokes
• Kawasaki-like
syndrome
• Changing strains of
the virus
NYC COVID-19 Cases- as of 5/3
NYC COVID-19 Hospitalizations-
as of 5/3
NYC COVID-19 Deaths- as of 5/4
Rates by Borough
Cases by Age and Gender
Hospitalizations and Deaths by Gender
Hospitalizations and Deaths by
Race/Ethnicity
Milestones Used to Guide Social Distancing Policies
Clinical Takeaways
• This is truly unlikely anything our modern day healthcare system
has ever experienced
• Approach embodies art > science of medicine
• Many experimental treatments tried in absence of good
evidence/guidance on who/when to treat
– Hydroxychloroquine +/- Azithromycin
– Remdesivir
– Convalescent plasma
– Tocilizumab/Sarilumab
– Anticoagulation
– Steroids
• A collaborative healthcare system can work wonders to offload
surge and save lives
21
Thank You!
www.weitzmaninstitute.org/coronavirus

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Weitzman ECHO COVID-19: Clinical Presentations and Lessons Learned from the Front Lines

  • 1. COVID-19 Clinical Presentations and Lessons Learned from the Front Lines May 13, 2020
  • 2. CME Credit • Bridgeport Hospital Yale New Haven Health is accredited by the Connecticut State Medical Society to sponsor continuing medical education for physicians. The Bridgeport Hospital Yale New Haven Health designates this live activity for a maximum of one (1) AMA PRA Category 1 CreditsTM. Physicians should claim only credits commensurate with the extent of their participation in the various activities. • This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of Bridgeport Hospital Yale New Haven Health and the Weitzman Institute. Bridgeport Hospital Yale New Haven Health is accredited by the Connecticut State Medical Society to provide continuing medical education for physicians. • The content of this activity is not related to products or services of an ACCME- defined commercial interest; therefore, no one in control of content has a relevant financial relationship to disclose and there is no potential for conflicts of interest.
  • 4. Objectives - Update on epidemiology (SARS-CoV-2, COVID-19) - Review any good news? - Continue team efforts to fight the virus
  • 5. COVID-19 in the United States 1,367,491 cases on 5/12/20 – up from 1,203,673 cases last week (5/5/20) - https://coronavirus.jhu.edu/map.html
  • 6. Any good news? • Remdesivir: –Gilead to allow wide-spread generic development • Continuing the fight: –10,000th COVID-19 discharge
  • 8. Stay safe -- Stay up to date • https://www.cdc.gov/coronavirus/2019- ncov/index.html https://emergency.cdc.gov/coca/calls/2020/ • https://www.who.int/emergencies/disea ses/novel-coronavirus-2019 • https://covidactnow.org/ • https://coronavirus.jhu.edu/map.html
  • 9. COVID-19: Clinical Presentations and Lessons Learned from the Front Lines Joseph Masci, MD Chairman of Global Health, Elmhurst Hospital Center Professor of Medicine, Infectious Disease & Emma Kaplan-Lewis, MD HIV Clinical Quality Director, NYC Health and Hospitals Assistant Professor of Medicine, Infectious Disease
  • 10. Outline • Unexpected Findings • Demographics of COVID-19 in NYC • Indicators used to inform policy (ie. Social distancing) • Clinical takeaways
  • 11. Unexpected Findings • Pulmonary disease • Renal disease • Heart disease • Liver disease • Hypercoagulable state • Strokes • Kawasaki-like syndrome • Changing strains of the virus
  • 12. NYC COVID-19 Cases- as of 5/3
  • 14. NYC COVID-19 Deaths- as of 5/4
  • 16. Cases by Age and Gender
  • 18. Hospitalizations and Deaths by Race/Ethnicity
  • 19. Milestones Used to Guide Social Distancing Policies
  • 20. Clinical Takeaways • This is truly unlikely anything our modern day healthcare system has ever experienced • Approach embodies art > science of medicine • Many experimental treatments tried in absence of good evidence/guidance on who/when to treat – Hydroxychloroquine +/- Azithromycin – Remdesivir – Convalescent plasma – Tocilizumab/Sarilumab – Anticoagulation – Steroids • A collaborative healthcare system can work wonders to offload surge and save lives
  • 21. 21