WordPress must-use (MU) plugins provide critical functionality that cannot be disabled. They are placed in the wp-content/mu-plugins folder and run independently of regular plugins or themes. While MU plugins cannot be disabled or uninstalled, they are useful for network-wide settings, custom post types, taxonomies, and other core functionality. Developers must maintain MU plugins themselves since there are no automatic updates. Common uses include initializing custom post types, handling redirects, and removing admin menus.