Workshop pdf
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This document provides an introduction to molecular diagnostics, past, present, and future. It discusses how molecular diagnostics can be used throughout life for prenatal testing, disease predisposition, disease detection, drug selection, and recurrence monitoring. Molecular diagnostics allows for faster and more targeted diagnostic results and therapies through techniques like genetic testing, molecular oncology testing, pharmacogenetics testing, and more. The future of medicine is one where diagnosis and treatment meet at the molecular level through precision diagnostics.
Workshop pdf
- 1. Introduction to: MOLECULAR DIAGNOSTICS Past, Present and Future Omer Yahia M.Sc. Molecular medicine
- 2. Content: • Molecular medicine. • Genetic diseases VS environmental diseases • Development of diagnosis. • Molecular diagnostics. • Role of molecular diagnostic through out life. • Areas of molecular diagnostics. • Drug selection in cancer.
- 3. Molecular medicine The application of molecular biology to medicine. • Molecular biology applications are Genetics Genomics Proteomics The study of the form, function and interactions of the proteins of an organism. Deals with the laws of inheritance and the properties of genes. The study of the form, function and interactions of the genes of an organism.
- 4. Genetic Diseases VS environmental diseases
- 5. Genetic diseases Aneuploidy SNP Cancer is a complex disease Genetic + environmental
- 6. How gene mutation cause disease
- 7. Eye Observation light Microscopic observation Electron microscopic observation molecular diagnostic Development of Diagnostics J. Herrick 1910. Rudolf Virchow (1821–1902) Giovanni Battista Morgagni (1682–1771) Hans Busch (1926) Vernon Ingram 1950 AmpliChip CYP450 test 2003 Z O O M
- 8. Main events affect Molecular diagnostics
- 9. Molecular Diagnostics: Is a technique used to analyze biological markers in the genome and proteome by applying molecular biology to medical testing
- 10. Pre-natal testing Disease predisposition Disease detection Drug selection Recurrence monitoring Key questions -> Need for Molecular tests “Is the baby healthy? “ “What diseases is this patient at risk for?” “Has this patient a disease?” “What drugs should I prescribe?” “How has the disease returned?” Role of molecular diagnostics through out the life Angelina Jolie HIV viral load
- 11. They result in faster diagnostic results, more targeted therapies and shorter hospitalization, which in their turn reduce health care costs.. Infectious diseases molecular Testing. Areas of molecular diagnostics Molecular oncology testing. Inherited diseases molecular Testing Tissue type testing HLA typing or histocompatibility testing Identity testing DNA Fingerprinting Pharmacogenetics testing
- 12. For the first time in the history of medicine, diagnosis and therapy are meeting on common ground Diagnosis Treatment Molecular Diagnostic Pharmacogenetics testing
- 13. Treat: Responders and Patients Not Predisposed to Toxicity All patients with same diagnosis Remove: (1) non-responders (2) toxic responders
- 14. Drug selection in Cancer
- 15. A. Increased growth factor production
- 16. B. Increased growth factor receptors
- 18. D. Mutant transcription factors