House mice thrive in human structures where they find abundant food and shelter. They can contaminate and damage food supplies, transmit diseases, and gnaw on buildings. House mice are best managed by removing food and shelter sources, sealing entry points into buildings, and using traps or baits. Signs of an infestation include droppings, gnawing marks, smells, and sightings of the mice. Proper sanitation and exclusion practices can discourage house mice from entering homes.