Your Advocacy at Work: The DoD Academy, Karen Wylie, PhD
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The document provides an overview of the Department of Defense Ovarian Cancer Research Program (DoD OCRP). It discusses the history and organization of the Congressionally Directed Medical Research Programs (CDMRP) and the DoD OCRP. It summarizes the vision, mission, and funding amounts of the DoD OCRP. It also describes some of the key initiatives funded by the DoD OCRP, including the Consortium Award focusing on prevention, the Outcomes Consortium Award focusing on increasing survivorship, and the Ovarian Cancer Academy aimed at developing the next generation of ovarian cancer researchers.
Your Advocacy at Work: The DoD Academy, Karen Wylie, PhD
- 1. Overview of the DoD Ovarian Cancer Research Program Karen Wylie, Ph.D. DoD OCRP Science Officer The Geneva Foundation, In support of the Congressionally Directed Medical Research Programs The views expressed in this presentation are those of the author and may not reflect the official policy or position of the Department of the Army, Department of Defense, or the U.S. Government.
- 2. 2 Outline Overview of DoD OCRP & CDMRP DoD OCRP consumers Impact of the DoD OCRP Consortium Award Outcomes Consortium Award Ovarian Cancer Academy
- 3. 3 History of the CDMRP and DoD OCRP Congressionally Directed Medical Research Programs (CDMRP) Organization which funds biomedical research globally Unique partnership: U.S. Congress, Public & U.S. Military 1992 grassroots campaign to increase Breast Cancer research funding Congress responded, DoD directed to manage $210 M CDMRP established, Breast Cancer Research Program 1st program In 1997, the Ovarian Cancer Research Program (OCRP) was added to CDMRP with an initial appropriation of $7.5 M. FY1992 – FY2015 CDMRP has Grown to include 27 research programs Cancer, neurologic, orthopedic and military relevant areas Managed ~$9.7 Billion in appropriations
- 4. 4 How does the OCRP fit into the DoD? ARMY MEDICAL COMMAND (MEDCOM) DEPARTMENT OF DEFENSE DEPARTMENT OF THE ARMY MEDICAL RESEARCH AND MATERIEL COMMAND (USAMRMC) CONGRESSIONALLY DIRECTED MEDICAL RESEARCH PROGRAMS OCRP OVARIAN CANCER RESEARCH PROGRAM
- 5. 5 DoD OCRP Vision and Mission Vision: Eliminate ovarian cancer. Mission: To support patient-centered research to prevent, detect, treat & cure ovarian cancer. FY1997–FY2015 DoD OCRP managed appropriations of $256.5 M DoD OCRP addresses critical issues for the OC patient & research communities through different funding opportunities.
- 6. 6 Outline Overview of DoD OCRP & CDMRP DoD OCRP consumers Impact of the DoD OCRP Consortium Award Outcomes Consortium Award Ovarian Cancer Academy
- 7. 7 DoD OCRP Consumers: Role and Numbers Who is an OCRP consumer? An OCRP consumer is a patient or a survivor living with ovarian cancer. OCRP Consumer contributions Peer Review: 94, who provided reviews for 225 panel assignments Programmatic Review: 9 Standing reviewers 10 Ad-hoc reviewers
- 8. 8 Unique Partnerships Demonstrate need Participate at all levels Passion and perspective Innovation and gaps Risk/Benefit Product- oriented Add funds to budget Targeted guidance Program management Contracting actions Regulatory requirements IMPROVE HEALTH OUTCOME
- 9. 9 DoD OCRP Funding 0 5 10 15 20 25 FY97 FY98 FY99 FY00 FY01 FY02 FY03 FY04 FY05 FY06 FY07 FY08 FY09 FY10 FY11 FY12 FY13 FY14 FY15 FY16 Millions($) Fiscal Year Congressional Appropriations for DoD OCRP FY97-FY16
- 10. 10 Outline Overview of DoD OCRP & CDMRP OCRP consumers Impact of the DoD OCRP Consortium Award Outcomes Consortium Award Ovarian Cancer Academy
- 11. 11 Impact of the DoD OCRP Unmet Needs / Long-Term Research Priorities Understand initiation and progression of OC Develop / improve diagnosis and treatment Increase prevention, improve QOL for survivors Investigate tumor response / resistance to treatment Develop and validate research tools to study OC Recruit / retain exceptional OC researchers
- 12. 12 DoD OCRP Consortium Award Focus … Prevention Intent To support a major multi-institutional research effort Focus on identifying and characterizing early changes in OC Innovative studies to reduce burden of OC through prevention. FY10 Consortium Award: Dr. Kurman’s group / JHU “Prevention of Ovarian High-Grade Serous Carcinoma by Elucidating Its Early Changes” 4 preclinical & 1 epidemiology project; JHU, MSKCC, Yale & UHN Toronto Hypothesis: Precursor of many HGSCs begins in the fallopian tube Results: Evaluated STICS as precursor lesions of HGSCs Identifying molecular changes that precede the development of STICs Website: http://www.ovariancancerprevention.org/
- 13. 13 Outcomes Consortium Award Focus … Increase Survivorship Intent Identify & understand predictors of disease outcomes Shift balance: Short-Term Survivors to Long-Term Survivors FY15 Outcomes Consortium Award Impact: accelerate predictors of disease outcomes into patient care. Consumer advocates involved in significant aspects of the proposed project such as design, recruitment, and evaluation Two 4-year awards made by September 2016
- 14. 14 Outcomes Consortium Award Focus … Increase Survivorship Dr. Birrer’s group (Massachusetts General Hospital) “The Genomic, Epigenomic, & Quality-of-Life Characteristics of Long-Term Survivors of OC” Characterize genomic, biologic, and biobehavioral basis for long-term survivors of epithelial OC Dr. Pike’s group (Memorial Sloan Kettering Cancer Ctr.) “Multidisciplinary Ovarian Cancer Outcomes Group (MOCOG)” Investigate genetic, genomic, immune, & epidemiological factors that may contribute, singly or in combination, to long- term survival
- 15. Ovarian Cancer Academy: The Need “Reducing the burden of ovarian cancer requires recruiting and, more importantly, mentoring a group of scientists and clinicians who are committed to building sustained and productive careers in ovarian cancer research.” Dr. Michael Seiden, Integration Panel Chair, FY09 Building a Critical Mass of Dedicated OC Researchers
- 16. 16 Ovarian Cancer Academy: Challenges Challenges in Producing Dedicated OCRP Researchers Limited number of medical or research centers with critical mass of mentors dedicated to OC research Funding an institutional training grant at a single institution is expensive and often ineffective Too few junior scientists and physicians heading into OC as a research career choice Peer groups for junior faculty interested in OC often limited within their institutions
- 17. 17 Ovarian Cancer Academy: Breaking Barriers Focus…Seeding Next Generation of Dedicated OC Researchers Interactive Academy in a Virtual Environment Consists of: Academy Dean and Assistant Dean ~14 Early-Career Investigator (ECI)-Designated Mentor pairs from different institutions Provides Mentoring Networking Peer group Collaborative opportunities
- 18. 18 Ovarian Cancer Academy (OCA) OCA: Early-Career Investigators, their Mentors and Leadership
- 19. 19 Search Awards Site http://cdmrp.army.mil Research Highlights/News » 19 Search Awards & PublicationsResearch Programs
- 20. 2020 Thank you… For Your Unwavering Support