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 Beginning in the retina, the visual pathway continues
 through the optic nerves,
 optic chiasm,
 and optic tracts to synapse in
 the lateral geniculate nucleus (LGN).
 From the LGN, it extends through
 the temporal and parietal lobes
 to terminate in the occipital lobes
 The retina is a thin, multilayered tissue sheet containing
three developmentally distinct, interconnected cell groups
that form signal processing networks:
 • Class 1 :: sensory neuroepithelium (SNE) ::
photoreceptors and BCs
 • Class 2 :: multipolar neurons :: GCs, ACs, and axonal cells
(AxCs)
 • Class 3 :: gliaform neurons :: horizontal cells (HCs)
Visual pathways
Visual pathways
Visual pathways
Visual pathways
Enlargement of blind spot
Altitudinal field defect
 Ischaemic optic neuropathy
 Branch retinal artery occlusion
 Inferior retinal coloboma
10
Development of the Optic Nerve:
 Embryonic optic stalk
 Progressively gets
occupied by axons
ganglion cells of retina
 Myelin sheath 
oligodendrocytes
11
Parts of Optic Nerve:
47-50 mm in length
Intraocular (1 mm)
Intraorbital (25-30 mm)
Intracanalicular (5-9
mm)
Intracranial (10-16 mm)
12
Intra Ocular Part
13
1a-Internal limiting
membrane of
retina
1b-Inner limiting
membrane of
Elschnig
2-Central meniscus
of Kuhnt
3- Spur of
collagenous tissue
separating the
anterior lamina
cribrosa (6) from
the choroid
4-Border tissue of
Jacoby
5- Intermediary
tissue of Kuhnt
7-Posterior lamina
cribrosa
14
Internal limiting membrane of
Elschnig
Central meniscus of Kuhnt
Border
tissue of
Elschnig
Border
Tissue
Of
Jacoby
Intermediat
e
Tissue
Of
Kuhnt
INTRA ORBITAL PART:
Anteriorly: Separated from extraocular muscle by orbital fat
Posteriorly: Annulus of Zinn
Laterally: Ciliary ganglion,Division of 3rd nerve, Nasociliary nerve,
Sympathetic plexus, Abducent nerve
Ophthalmic artery
Superior ophthalmic vein cross optic nerve from lateral to medial
Nasociliary nerve
15
INTRA CRANIAL PART:
16
Lies above the
cavernous sinus
Optic chiasma is
formed just
above the sellae
Covered by Pia
only
1) LESIONS OF OPTIC NERVE :
Causes:
1. Optic atrophy
2. Indirect optic neuropathy
3. Acute optic neuritis
4. Traumatic avulsion of optic nerve.
Characterised by:
Complete blindness in affected eye with loss of both direct
on ipsilateral & consensual light reflex on contralateral
side.
Near reflex is preserved.
Eg. Right optic nerve
involvement
17
Optic chisam
 Floor of the third ventricle.
 5-10 mm above the diphragma sella and the
hypophysis cerebri.
 12mm wide, 8mm A-P , 4 mm thick.
 Important relations: 3rd ventricle, hypothalmus,
pituitary stalk, sella, dorsum sellam anterior and
posterior clinoid processes, cavernous sinus.
 Nasal fibers cross ; temporal fibers do not (53:47).
 Wilband’s knee.
Chiasm
Visual pathways
Location of chiasma
 Central fixation -80%- above the sella
 Pre fixed chiasm-10%-located anteriorly-
so pitutary tumour involves the optic tract
first [lower temporal fields first]
 Post fixed chiasm-10%-located posteriorly-
so optic nerve gets involved first
[upper temporal fields first]
Pitutary adenoma
 Visual fields ; bitemporal hemianopia,junctional
scotoma,
bitemporal hemianopic scotoma
 Colour vision; early red deficit
 Visual acuity tends to reduce
 Optic disc- bow tie atrophy rarely papilloedema
 Extraocular movements: cranial nerve palsies,see saw
nystagmus,spasm nutans.
Visual pathways
Wilbrand’s knee
OPTIC TRACT:
* Flattened cylindrical band that
travel posteriolaterally from
angle of chiasma
* Between tuber cinereum and
anterior perforated substance
upto lateral geniculate body.
* Each tract contains
uncrossed temporal
fibres and crossed nasal fibres .
25
OPTIC TRACT:
 Macular fibers (crossed
& uncrossed) occupy
dorsolateral aspect of
optic tract
 Upper peripheral fibers
(crossed &
uncrossed)medially
situated
 Lower peripheral
fibers laterally
situated
26
Visual pathways
OPTIC TRACT
 Carries ipsilateral temporal fibres and
controlateral nasal fibres and pupillary fibres.
 So right optic tract lesion will cause left
homonymous hemianopia
ASSOCIATIONS
 Controlateral pyramidal signs.
 Incongruous homonymous hemianopia.
 Wernicke's hemianopic pupil
 Optic atrophy
Fibers from optic tract:
30
Superior
Colliculus
Pretectal
nucleus
Dorsal
Lateral
geniculate
nucleus
LATERAL GENICULATE BODY:Elevation produced by
lateral geniculate
nucleus in which most
optic tract fibers end
Axons of ganglion cells of
retina synapse with
dendrites of LGB cells
3rd order neurons begins
31
LATERAL GENICULATE BODYDorsal nucleus
Ventral nucleus (rudimentary)
6 laminae( alternating grey & white
matter)
Axons from the ipsilateral eye –
2, 3, 5
Axons from the contralateral eye - 1, 4,6
32
Lateral Geniculate Body: Large magnocellular
neurons (M cells) - 1 and 2
layer-Y ganglion cells
perception of movement, gross
depth, and small differences
in brightness
 Small parvocellular
neurons (P cells)- 3,4,5,6
layer- X ganglion cells
Colour perception, texture
shape & fine depth
 Koniocellular cells(K cells
or interlaminar cells)
Short-wavelength "blue" cones
33
LATERAL GENICULATE BODY:
34
Macular fibres - posterior
2/3 of LGB
Upper retinal fibres -
medial half of anterior 1/3
of LGB
Lower retinal fibres -
lateral half of anterior 1/3
of LGB
Visual pathways
OPTIC RADIATION:
36
Inferior
retinalower
part of optic
radiation
superior retina
upper part of
optic radiation
OPTIC RADIATIONS:
Geniculocalcarine
pathway extend from
lateral geniculate body
 visual cortex
MEYERS LOOP(inferior
retinal fibers)-pass
through temporal lobe
looping around
inferior horn of lateral
ventricle
37
Visual pathways
OPTIC RADIATIONS
 The corresponding retinal elements lie
progressively closer, so congruous
hemianopia.
 Passes through the temporal lobe and pareital
lobe and ends in the visual cortex.
TEMPORAL LOBE
 Controlateral congruous homonymous
superior quadrantanopia[pie in the sky]
 Controlateral hemisensory disturbance
 Mild hemiparesis
 Paraxysomal olfactory and uncinate fits.
 Formed visual hallucinations
 Seizures and receptive dysphasia.
VISUAL CORTEX(CORTICAL
RETINA):
41
•Impulse from
corresponding 2 points
of retina meet
•Right visual
cortexreceive
impulse left half of
visual field
•Left visual
cortexreceive
impulse from right half
visual field
MACULA posteriorly
PERIPHERAL RETINA anteriorly
UPPER RETINA above calcarine sulcus
LOWER RETINA below the calcarine sulcus
Pie in the sky
PAREITAL LOBE
 Controlateral congruous homonymous inferior
quadrantanopia[pie on the floor]
 Visual perception difficulties
 Right-left confusion
 Acalculia
 Assymmetric OKN.[OKN response diminished
towards the side of the lesion.]
Pie on the floor
Visual Cortex:
Striate cortex Extrastriate cortex

45
46
Anterior
Knee of
Von-wille
Brand
Posterio
r
Knee of
Von-
wille
Brand
LATERAL GENICULATE BODY:

47
CROSSED FIBERS- 1,4,6
UNCROSSED FIBERS- 2,3,5
CORRESPONDING PART OF 2
RETINA END IN NEIGHBOURING
PART OF ADJACENT LAMINAE
smallest lesion of retina results in
degeneration of 3 laminae of LGB in
which the retinal fiber end
Optic radiation begins from all 6
laminae lesion of visual cortex will
cause degeneration of all 6 laminae
TWO STREAM HYPOTHESIS:
 Ventral
48
Ventral
Pathway(parvocellular)

temporal lobe
Dorsal
Pathway(magnocellular
) parietal lobe
Recognistion
&
indentificatio
n
Spatial
location
Visual
agnosia
Visual
neglec
t
Parvocellula
r “what”
pathway
Magnocellula
r
“where”
pathway
Visual pathways
Striate calcarine cortex
 Congruous homonymous hemianopias
with macular sparing, macular
involvement alone.
 Formed visual hallucinations.
 Anton's syndrome[ denial of blindness]
 Riddoch phenomenon
Visual pathways
52

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Visual pathways

  • 2.  Beginning in the retina, the visual pathway continues  through the optic nerves,  optic chiasm,  and optic tracts to synapse in  the lateral geniculate nucleus (LGN).  From the LGN, it extends through  the temporal and parietal lobes  to terminate in the occipital lobes
  • 3.  The retina is a thin, multilayered tissue sheet containing three developmentally distinct, interconnected cell groups that form signal processing networks:  • Class 1 :: sensory neuroepithelium (SNE) :: photoreceptors and BCs  • Class 2 :: multipolar neurons :: GCs, ACs, and axonal cells (AxCs)  • Class 3 :: gliaform neurons :: horizontal cells (HCs)
  • 9. Altitudinal field defect  Ischaemic optic neuropathy  Branch retinal artery occlusion  Inferior retinal coloboma
  • 10. 10
  • 11. Development of the Optic Nerve:  Embryonic optic stalk  Progressively gets occupied by axons ganglion cells of retina  Myelin sheath  oligodendrocytes 11
  • 12. Parts of Optic Nerve: 47-50 mm in length Intraocular (1 mm) Intraorbital (25-30 mm) Intracanalicular (5-9 mm) Intracranial (10-16 mm) 12
  • 14. 1a-Internal limiting membrane of retina 1b-Inner limiting membrane of Elschnig 2-Central meniscus of Kuhnt 3- Spur of collagenous tissue separating the anterior lamina cribrosa (6) from the choroid 4-Border tissue of Jacoby 5- Intermediary tissue of Kuhnt 7-Posterior lamina cribrosa 14 Internal limiting membrane of Elschnig Central meniscus of Kuhnt Border tissue of Elschnig Border Tissue Of Jacoby Intermediat e Tissue Of Kuhnt
  • 15. INTRA ORBITAL PART: Anteriorly: Separated from extraocular muscle by orbital fat Posteriorly: Annulus of Zinn Laterally: Ciliary ganglion,Division of 3rd nerve, Nasociliary nerve, Sympathetic plexus, Abducent nerve Ophthalmic artery Superior ophthalmic vein cross optic nerve from lateral to medial Nasociliary nerve 15
  • 16. INTRA CRANIAL PART: 16 Lies above the cavernous sinus Optic chiasma is formed just above the sellae Covered by Pia only
  • 17. 1) LESIONS OF OPTIC NERVE : Causes: 1. Optic atrophy 2. Indirect optic neuropathy 3. Acute optic neuritis 4. Traumatic avulsion of optic nerve. Characterised by: Complete blindness in affected eye with loss of both direct on ipsilateral & consensual light reflex on contralateral side. Near reflex is preserved. Eg. Right optic nerve involvement 17
  • 18. Optic chisam  Floor of the third ventricle.  5-10 mm above the diphragma sella and the hypophysis cerebri.  12mm wide, 8mm A-P , 4 mm thick.  Important relations: 3rd ventricle, hypothalmus, pituitary stalk, sella, dorsum sellam anterior and posterior clinoid processes, cavernous sinus.  Nasal fibers cross ; temporal fibers do not (53:47).  Wilband’s knee.
  • 21. Location of chiasma  Central fixation -80%- above the sella  Pre fixed chiasm-10%-located anteriorly- so pitutary tumour involves the optic tract first [lower temporal fields first]  Post fixed chiasm-10%-located posteriorly- so optic nerve gets involved first [upper temporal fields first]
  • 22. Pitutary adenoma  Visual fields ; bitemporal hemianopia,junctional scotoma, bitemporal hemianopic scotoma  Colour vision; early red deficit  Visual acuity tends to reduce  Optic disc- bow tie atrophy rarely papilloedema  Extraocular movements: cranial nerve palsies,see saw nystagmus,spasm nutans.
  • 25. OPTIC TRACT: * Flattened cylindrical band that travel posteriolaterally from angle of chiasma * Between tuber cinereum and anterior perforated substance upto lateral geniculate body. * Each tract contains uncrossed temporal fibres and crossed nasal fibres . 25
  • 26. OPTIC TRACT:  Macular fibers (crossed & uncrossed) occupy dorsolateral aspect of optic tract  Upper peripheral fibers (crossed & uncrossed)medially situated  Lower peripheral fibers laterally situated 26
  • 28. OPTIC TRACT  Carries ipsilateral temporal fibres and controlateral nasal fibres and pupillary fibres.  So right optic tract lesion will cause left homonymous hemianopia
  • 29. ASSOCIATIONS  Controlateral pyramidal signs.  Incongruous homonymous hemianopia.  Wernicke's hemianopic pupil  Optic atrophy
  • 30. Fibers from optic tract: 30 Superior Colliculus Pretectal nucleus Dorsal Lateral geniculate nucleus
  • 31. LATERAL GENICULATE BODY:Elevation produced by lateral geniculate nucleus in which most optic tract fibers end Axons of ganglion cells of retina synapse with dendrites of LGB cells 3rd order neurons begins 31
  • 32. LATERAL GENICULATE BODYDorsal nucleus Ventral nucleus (rudimentary) 6 laminae( alternating grey & white matter) Axons from the ipsilateral eye – 2, 3, 5 Axons from the contralateral eye - 1, 4,6 32
  • 33. Lateral Geniculate Body: Large magnocellular neurons (M cells) - 1 and 2 layer-Y ganglion cells perception of movement, gross depth, and small differences in brightness  Small parvocellular neurons (P cells)- 3,4,5,6 layer- X ganglion cells Colour perception, texture shape & fine depth  Koniocellular cells(K cells or interlaminar cells) Short-wavelength "blue" cones 33
  • 34. LATERAL GENICULATE BODY: 34 Macular fibres - posterior 2/3 of LGB Upper retinal fibres - medial half of anterior 1/3 of LGB Lower retinal fibres - lateral half of anterior 1/3 of LGB
  • 36. OPTIC RADIATION: 36 Inferior retinalower part of optic radiation superior retina upper part of optic radiation
  • 37. OPTIC RADIATIONS: Geniculocalcarine pathway extend from lateral geniculate body  visual cortex MEYERS LOOP(inferior retinal fibers)-pass through temporal lobe looping around inferior horn of lateral ventricle 37
  • 39. OPTIC RADIATIONS  The corresponding retinal elements lie progressively closer, so congruous hemianopia.  Passes through the temporal lobe and pareital lobe and ends in the visual cortex.
  • 40. TEMPORAL LOBE  Controlateral congruous homonymous superior quadrantanopia[pie in the sky]  Controlateral hemisensory disturbance  Mild hemiparesis  Paraxysomal olfactory and uncinate fits.  Formed visual hallucinations  Seizures and receptive dysphasia.
  • 41. VISUAL CORTEX(CORTICAL RETINA): 41 •Impulse from corresponding 2 points of retina meet •Right visual cortexreceive impulse left half of visual field •Left visual cortexreceive impulse from right half visual field MACULA posteriorly PERIPHERAL RETINA anteriorly UPPER RETINA above calcarine sulcus LOWER RETINA below the calcarine sulcus
  • 42. Pie in the sky
  • 43. PAREITAL LOBE  Controlateral congruous homonymous inferior quadrantanopia[pie on the floor]  Visual perception difficulties  Right-left confusion  Acalculia  Assymmetric OKN.[OKN response diminished towards the side of the lesion.]
  • 44. Pie on the floor
  • 45. Visual Cortex: Striate cortex Extrastriate cortex  45
  • 47. LATERAL GENICULATE BODY:  47 CROSSED FIBERS- 1,4,6 UNCROSSED FIBERS- 2,3,5 CORRESPONDING PART OF 2 RETINA END IN NEIGHBOURING PART OF ADJACENT LAMINAE smallest lesion of retina results in degeneration of 3 laminae of LGB in which the retinal fiber end Optic radiation begins from all 6 laminae lesion of visual cortex will cause degeneration of all 6 laminae
  • 48. TWO STREAM HYPOTHESIS:  Ventral 48 Ventral Pathway(parvocellular)  temporal lobe Dorsal Pathway(magnocellular ) parietal lobe Recognistion & indentificatio n Spatial location Visual agnosia Visual neglec t Parvocellula r “what” pathway Magnocellula r “where” pathway
  • 50. Striate calcarine cortex  Congruous homonymous hemianopias with macular sparing, macular involvement alone.  Formed visual hallucinations.  Anton's syndrome[ denial of blindness]  Riddoch phenomenon
  • 52. 52

Editor's Notes

  • #12: Begins anatomically at optic disc but physiologically & functionally within the ganglion cell layer that covers retina Outgrowth of the cerebral vesicle, develops from nerve fibre layer of retina than grow into optic stalk by passing through choroidal fissure and pass posteriorly to brain. Glial system of nerve develops from neuroectodermal cell of outer wall of optic stalk. Myelination of nerve fiber begins from chiasma at 7th month grow distally to reach lamina cribriosa before birth. Not covered by Neurilemma so does not regenerate when cut. Fibres are 2-10 um in diameter & 47-50mm long. Surrounded by meninges . Both the first order(bipolar cells) & second order(ganglion cells) neurons are in the retina.
  • #14: Extends from anterior surface in contact with vitreous to a plane which is in parallel with posterior scleral surface
  • #15: 1)Surface nerve fiber layer covered by inner limiting membrane of Elschnig,center portion of this membrane is thickened and is called central meniscus of Kuhnt composed of astrocytes(10%)& nerve fibers of retina is in continuity with inner limiting membrane of retina 2)Prelaminar Region Neurons & astroglial tissue Border tissue of Jacoby separates it from choroid 3)Lamina Cribrosa dense band ofConnective and elastic tissue and contains fenestrations for passage of nerve fibres and blood vessels embrased by trabeculae. Maintains IOP bet intra and extra ocular spaces. Blood Supply from Circle of Zinn 4) Retrolaminar Myelinated nerve fibres DECREASE IN ASTROCYTES, Oligodendrocites are in large amount  form the myelin This doubles the diameter from 1.5mm to 3 mm Invested by thick sheath of dura, arachnoid,pia Carry blood vessel to optic nerve
  • #16: Back of the eyeball upto optic foramina Covered by all 3 meninges Posteriorly near optic foramen, optic nerve is closely surrounded by annulus of zinn and origin of 4 rectus muscle Some fibers of superior & medial rectus are adherent to sheath here painful ocular movements(elevation and adduction) seen in retrobulbar neuritis.
  • #17: Lie above the cavernous sinus and converge with other side optic nerve to form optic chiasma over the diaphragm sellae Covered by pia only Above lie the gyri recti of the frontal lobes of the brain. Lateral side lie the internal carotid artery, or alternatively the anterior cerebral and middle cerebral arteries. Ophthalmic artery lies to the lateral side and below the nerve. Proximity of cavernous sinus makes it possible for tumors to produce cranial nerve palsies in combination with an optic neuropathy.
  • #34: Function : 1)relay station 2) to gate the transmission of signals Large magnicellular neurons (M cells) - 1 and 2 –receive input from Y ganglion cells of retina(10% seen in periphearl retina) Motion detection transmitts only black and white information Small parvicellular neurons (P cells) - 3,4,5,6 layers-receive input from X ganglion cells of retina Colour perception –texture shape fine depth vision
  • #37: Fibres from inferior retina (Meyer’s loops) Pass through temporal lobe looping around the inferior horn of lateral ventricleInformation from the superior part of visual fieldLoss of vision in superior quadrant ( quadrantanopia or ‘pie in sky defect) Fibres from superior retina (Baum’s loop) Parietal lobe occipital lobe internal capsule visual cortex Information from the inferior part of visual field. Vascular lesion of internal capsulehemiplegia & homonymous hemianopia
  • #38: The fibres of optic radiation spread out fanwise to form medullary optic lamina The inferior fibres of optic radiation subserve upper visual field & the superior fibres subserve lower visual field . Ends in a extensive area of thin occipital cortex in which is a distinctive white stripe , striae of Gennari visible to naked eyehence the name areastriate
  • #42: Called cortical retina since true copy of retinal image is formed here. Only in visual cortex impulse originating from corresponding point of two retina meet. Right visual cortexreceive impulse from temporal half of right retina & nasal half of left retina(left half visual field) Left visual cortexreceive impulse from temperal half of left retina & nasal half of right retina & (right half visual field)
  • #46: VISUOSENSORY AREA:Medial aspect of the occipital lobe around and in the calcarine sulcus, with extension into cuneus and lingual gyrus variably into lateral aspect of occipital pole limited by sulcus lunateus (Brodmann area 17 or V1) VISUOPSYCHIC AREA:peristriate area 18 &19 V1- primary visual area V2- greater part of area 18 V3- narrow stripe over anterior part of area 18 V4- within area 19 V5- posterior end of superior temporal gyrus
  • #47: Upper Nasal fibres involved first by lesions coming from above eg . Craniopharyngiomas Lower nasal fibres first affected in tumours of pituitary gland  upper temporal field defects. Ipsilateral blindness is associated with contralateral field defects.
  • #48: neuron of LGB form the 3rd order neurons There is point to point representation of retina in LGB SUCH THAT AREAS FROM CORRESPONDING PART OF 2 RETINA END IN NEIGHBOURING PART OF ADJACENT LAMINAE smallest lesion of retina results in degenration of 3 lamellae of LGB in which the retinal fiber end OPTIC RADIATION commence from all 6 laminae  so lesion of visual cortyex degenration of all 6 laminae Fibres from corresponding part of 2 retina end adjacent to each other So lesion in the retina will cause degeneration of 3 laminae in which the fibres end Since the optic radiation begin from all 6 laminae , lesion in cortex will cause degeneration of all 6 laminae .
  • #49: Ventral system(pavocellular):Recognition/identification, Long term stored representations,inputMainly foveal or parafoveal Dorsal system(magnocellular):spatial location, Only very short-term storage, Across retina