This document discusses the utility of intravascular ultrasound (IVUS) in percutaneous coronary intervention (PCI) for chronic total occlusions (CTOs). IVUS can be used to (1) evaluate the entry point and guide wire penetration, especially in ambiguous proximal caps or ostial lesions, (2) guide antegrade dissection and re-entry (ADR) strategy from the subintimal space, (3) confirm wire position and vessel sizing during reverse controlled antegrade and retrograde subintimal tracking (CART) techniques, and (4) evaluate vessel size and guide stent implantation to avoid injecting contrast into the subintimal space during difficult re-entries. The presentation provides examples of how IVUS