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Case II - Shock 
Fatima Al Awadh
Shock is a state of organ hypoperfusion with 
resultant cellular dysfunction and death. 
This deprives the organs and tissues of 
oxygen and allows the buildup of waste 
products. 
Symptoms include altered mental status, 
tachycardia, hypotension, and oliguria.
4. What is the effect of this 
kind of shock on the 
kidneys, the heart, the 
lungs, the brain and the 
intestine?
Brain 
Heart Lungs 
Intestine 
Kidneys
Low BP 
activates activates 
Hypothalamus 
release 
acts on 
Aldosterone Release 
Water/and Sodium retention 
Decreased Urine Output; 
Raised Urea and Creatinine 
Baroreceptors 
activates 
Sympathetic Nervous System 
causes 
Vasoconstriction 
causes 
Decreased Renal Blood Flow 
causes 
Renin Release 
Produces 
Angiotensin II 
causes 
ADH 
acts on
Critical Renal Hypoperfusion 
results in 
Kidney Injuries 
Acute Tubular Necrosis 
Renal Insufficiency
Brain 
Heart Lungs 
Intestine 
Kidneys
Low BP 
activates 
Baroreceptors 
activates 
Sympathetic Nervous System 
acts on 
Raised Heart Rate, myocardial contractility, and vasoconstriction 
Tachycardia; weak thready pulse
Coronary Hypoperfusion 
acts on 
Depress Contractility, and Worsen Myocardial Compliance 
results in 
Decreased Cardiac Output 
initiating 
A Vicious Cycle- Further Hypoperfusion
Brain 
Heart Lungs 
Intestine 
Kidneys
Low pH 
(why?) 
activates 
Chemoreceptors 
activates 
Respiratory Center 
acts on 
Raised Respiration Rate and Depth
Increased Membrane Permeability 
leads to 
Flooding of Alveoli 
stimulates 
Further Inflammation 
acts on 
Resistant Hypoxia 
Acute Lung Injury; or 
Acute Respiratory Distress Syndrome
Brain 
Heart Lungs 
Intestine 
Kidneys
Low pH 
causes 
Restlessness (early) 
Coma (late) 
Neuronal Depression 
leading to 
Cerebral Hypoperfusion 
Inhibation of metabolism and cell volume regulation 
stimulates 
leading to
Brain 
Heart Lungs 
Intestine 
Kidneys
Low BP 
activates 
Baroreceptors 
activates 
Sympathetic Nervous System 
causes 
Vasoconstriction 
causes 
Decreased Blood Flow 
acts on 
leading to Decreased Motility 
and Permeability
Decreased Motility 
and Permeability 
causes 
Ileus and Submucosal Hemorrhage
The human body responds to acute 
hemorrhage by activating some major 
physiologic systems resulting in 
changes in kidneys, heart, lungs, brain, 
and intestine.
“Thank 
You”

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Effects of shock

  • 1. Case II - Shock Fatima Al Awadh
  • 2. Shock is a state of organ hypoperfusion with resultant cellular dysfunction and death. This deprives the organs and tissues of oxygen and allows the buildup of waste products. Symptoms include altered mental status, tachycardia, hypotension, and oliguria.
  • 3. 4. What is the effect of this kind of shock on the kidneys, the heart, the lungs, the brain and the intestine?
  • 4. Brain Heart Lungs Intestine Kidneys
  • 5. Low BP activates activates Hypothalamus release acts on Aldosterone Release Water/and Sodium retention Decreased Urine Output; Raised Urea and Creatinine Baroreceptors activates Sympathetic Nervous System causes Vasoconstriction causes Decreased Renal Blood Flow causes Renin Release Produces Angiotensin II causes ADH acts on
  • 6. Critical Renal Hypoperfusion results in Kidney Injuries Acute Tubular Necrosis Renal Insufficiency
  • 7. Brain Heart Lungs Intestine Kidneys
  • 8. Low BP activates Baroreceptors activates Sympathetic Nervous System acts on Raised Heart Rate, myocardial contractility, and vasoconstriction Tachycardia; weak thready pulse
  • 9. Coronary Hypoperfusion acts on Depress Contractility, and Worsen Myocardial Compliance results in Decreased Cardiac Output initiating A Vicious Cycle- Further Hypoperfusion
  • 10. Brain Heart Lungs Intestine Kidneys
  • 11. Low pH (why?) activates Chemoreceptors activates Respiratory Center acts on Raised Respiration Rate and Depth
  • 12. Increased Membrane Permeability leads to Flooding of Alveoli stimulates Further Inflammation acts on Resistant Hypoxia Acute Lung Injury; or Acute Respiratory Distress Syndrome
  • 13. Brain Heart Lungs Intestine Kidneys
  • 14. Low pH causes Restlessness (early) Coma (late) Neuronal Depression leading to Cerebral Hypoperfusion Inhibation of metabolism and cell volume regulation stimulates leading to
  • 15. Brain Heart Lungs Intestine Kidneys
  • 16. Low BP activates Baroreceptors activates Sympathetic Nervous System causes Vasoconstriction causes Decreased Blood Flow acts on leading to Decreased Motility and Permeability
  • 17. Decreased Motility and Permeability causes Ileus and Submucosal Hemorrhage
  • 18. The human body responds to acute hemorrhage by activating some major physiologic systems resulting in changes in kidneys, heart, lungs, brain, and intestine.