This document discusses the concept of a Science DMZ, which consists of three key components: 1) a dedicated "friction-free" network path with high-performance networking devices located near the site perimeter to facilitate science data transfer, 2) dedicated high-performance data transfer nodes optimized for data transfer tools, and 3) a performance measurement/test node. It contrasts this approach with the typical ad-hoc deployment of a data transfer node wherever space allows, which often fails to provide necessary performance. Details of an example Science DMZ deployment at Lawrence Berkeley National Laboratory are provided.