Modern humans first appeared in Africa at least 315,000 years ago based on fossil evidence from Morocco. DNA evidence suggests humans may have emerged over 500,000 years ago. Anatomically modern humans spread from East Africa around 70,000 years ago, migrating along coastal regions to Australia, Europe, Asia, and the Americas. The evolution of humans and ancestral species over millions of years in Africa is characterized by increasingly larger and complex brains. Biochemical and genetic evidence from similarities in molecules like insulin and cytochrome c proteins across species supports the theory that all living organisms descended from a common ancestor through shared DNA and metabolic processes.