The document discusses developing good research questions in science. It advises that questions should seek new information rather than restating known facts. For researching wolves, it lists several facts already known, like that wolves are predators that live in packs, before suggesting questions about how changing environments have impacted wolf habitats or whether environmental policies have protected wolf populations. When considering chemical reactions, it mentions knowing about reaction types and energy changes before proposing a question about how antacid pH affects stomach pH. The document encourages applying existing knowledge to ask questions that can uncover new information.