Csir net chemistry bits 2
Download as PPTX, PDF0 likes37 views
The document discusses chemistry problems and solutions presented by B.Sateesh Kumar, an assistant professor of chemistry at GDC(M)-SKLM. It includes 3 chemistry problems involving the products of reactions and Kumar's explanations of the major products formed. Specifically, it discusses hydrogenolysis to deprotect functional groups on amino acids, the reduction of an epoxide to an alcohol using LAH, and a two-step reaction sequence involving a Schmidt reaction and Boc protection.
1 of 9
Download to read offline
More Related Content
What's hot (20)
Ad
More from Dr Sateesh Kumar Beepala (15)
Ad
Recently uploaded (20)
Csir net chemistry bits 2
- 1. B.SATEESH KUMAR ASSISTANT PROFESSOR IN CHEMISTRY GDC(M)-SKLM
- 3. B.SATEESH KUMAR , CHEMISTRY , GDC(M)-SKLM 1. The major product formed in the following reaction is….
- 4. It is very easy to solve here the reagent H2, 10% Pd/C, EtOH,used to deprotect the ‘Bn’ and Cbz in amino acid by hydrogenolysis. Boc not effected
- 5. B.SATEESH KUMAR , CHEMISTRY , GDC(M)-SKLM 2. The major product formed in the following reaction is…. You want solution just turn over the slide
- 6. B.SATEESH KUMAR , CHEMISTRY , GDC(M)-SKLM Solution: Answer :1 We know that LiAlH4 (LAH) is a very strong H- reducing agent. One mole of LAH is reduce only Epoxide into corresponding alcohol ,acetal is not effected Here epoxide Ring opening takes place from axial attack of H– at position (2),which is sterically free.
- 7. B.SATEESH KUMAR , CHEMISTRY , GDC(M)-SKLM 3. The major products A and B in the following reaction sequence are
- 8. Solution: Answer- 1 In first step Schmidt reaction here carboxylic acid reacts with azide gives isocyanate product (A) with same stereochemistry . In the second step t-BuOH reacts with isocyanate gives Boc Protected amino compound (B).