Formulation and Development of Matrix tablet In Drug Delivery System
- 1. FORMULATION AND DEVELOPMENT OF MATRIX TABLET IN DRUG DELIVERY SYSTEM BENGAL SCHOOL OF TECHNOLOGY SUBJECT:- PHARMACEUTICS -SAYAN PRAMANIK BACHELOR OF PHARMACY 4th YEAR 7th SEM
- 2. INTRODUCTION • Matrix tablet is an important tool for controlled and sustained release dosage forms. • The oral route remains the most common route for the administration of drugs. • Tablets offer the lowest cost approach to sustained and controlled release dosage forms. • Type of controlled drug delivery systems, which release the drug in continuous manner. • The hydrophilic polymer matrix is widely used in this dosage form. 2
- 3. ADVANTAGES • Easy to manufacture • Versatile, effective and low cost • Can be made to release high molecular weight compounds • Improvement in treatment efficacy. • Usage of less total drug. • Improvement the bioavailability of some drugs. • Reduce the toxicity. • Minimize the local and systemic side effects. • Increase the stability. • The remaining matrix must be removed after the drug has been released. • High cost of preparation. • Poor in vitro-in vivo correlation. • Higher cost of formulation DISADVANTAGES ADVANTAGES AND DISADVANTAGES OF MATRIX TABLET 3
- 4. CLASSIFICATION OF MATRIX TABLET • On the Basis of Retardant Material Used I) Hydrophobic Matrices II) Lipid Matrices III) Hydrophilic Matrices IV) Biodegradable Matrices V) Mineral Matrices • On the Basis of Porosity of Matrix I) Macro porous Systems II) Microporous System III) Non-porous System 4
- 5. POLYMERS USED IN SR DRUG DELIVERY SYSTEMS • Bio-degradable polymers: Alginates, Guar gum, Chitosan, Gelatin • Bio-absorbable polymers: Polyethylene glycol and polyvinylpyrrolidone • Bio-nondegradable polymers: Hydroxy propyl methyl cellulose 5
- 7. Preformulation Study Bulk Density Tapped Density Compressibility Index Hausner’s Ratio 7
- 8. FORMULATION OF MATRIX TABLET Manufacturing Process Sifting Dry mixing Binder Preparation Granulation Drying Sifting Pre- Lubrication Lubrication Compression Coating 8
- 9. Evaluations of Tablet 1. Weight Variation 2. Hardness 3. Thickness 4. Friability 5. Dissolution 9
- 10. Optimization Study on the basis presence of pH dependent polymer Formulation were modified with subject to pH independent polymer concentration of polymer and surfactant were changed Stability Studies Definition • the capacity of a drug substance to maintain its identity, quality and purity Objective • quality of the drug substance • shelf life for drug substance Method • 1st and 2nd month Stability testing • assay and% drug release of optimized batch was compared 10
- 11. CONCLUSION • By the above discussion, it can be easily concluded that sustained- release formulation is helpful in increasing the efficiency of the dose as well as they are also improving the patient’s compatibility. More over all these comes with reasonable cost. The dosage form is easy to optimize and very helpful in case of the antibiotics in which irrational use of the same may result in resistance. 11