Advances in tableitng technology
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1) Tablet manufacturing has advanced with new material handling, raw materials, granulation, coating, and compression technologies that improve efficiency and quality. 2) Advancements include direct compression excipients, dry and melt granulation methods, all-in-one systems, and single-step tablet coating and manufacturing processes. 3) New equipment allows for automated and continuous processing with improved control and monitoring from granulation to finished tablets.
Advances in tableitng technology
- 1. BY SAMEERA(M-PHARMACY) PULLA REDDY INSTITUTE OF PHARMACY
- 2. INTRODUCTION Tablets are oral solid dosage forms of medicinal substances usually prepared with the aid of suitable pharmaceutical adjuvants. Recent trends in tablet technology reduce the manual input and performing the process validation of each unit operation thus ensuring enhance product quality and process reliability.
- 3. Advancement in the material Handling Technology. Advancement in Raw Materials. Advancement in Granulation Technology. Advancement in Equipment Technology.
- 4. Advancement in Compression Technology. Advancement in Tablet Coating Materials. Advancement in the Tablet Coating Techniques. Advancement in Coating Equipment Technology.
- 5. Advancement in the material Handling Technology Disadvantages of Traditional manual handling of the materials is expensive, unsafe , delay in production & loss of material which ultimately affects product output. Advancement in the material handling can be explained by the case of MERCK SHARP & DOHME CO. which employs 3 storey building and 3 operational columns.
- 6. Material is transferred to the top by vacuum transfer systems and it is allow to flow under gravity through operational columns during which materials are processed for various unit operations ELLI-LILLY & Co. utilizes drive less trains to convey raw materials and vacuum powder transfer mechanism
- 7. Advancement in Raw Materials Recent trends in technology direct the material science to affect the flow properties & compressibility in order to get a directly compressible vehicle or multiple use excipients. So as to avoid multiple steps involved in the tablet manufacturing & subsequently to have one or two step technology. Ready to use co-processed blends for direct compression are available. Ex;-Indipress cellatose, Pharmatose DCL 40.
- 8. Commercially available ready-to-use co- processed blends are listed in the below table. Tablet Excipients Trade Name Composition Filler/disintegrant Avicel Microcrystalline cellulose Filler/disintegrant Elcema Micro fine cellulose Filler/disintegrant Sta-Rx 1500 Directly compressible starch Filler/binder Dipac 97% sucrose + 3% modified dextrins Filler/binder Emdex/cellutab 90-92% dextrose + 3-5% maltose
- 9. 1. Pneumatic Dry Granulation (PDG) 2. Freeze granulation Technology 3. Foamed Binder Technologies (FBT) 4. Melt Granulation Technology 5. Steam Granulation 6. Moisture Activated Dry Granulation (MADG) 7. Thermal Adhesion Granulation Process (TAGP)
- 10. 1. Pneumatic Dry Granulation (PDG) A novel dry method for automatic or semi- automatic production of granules . Pneumatic Dry Granulation Replaces Wet Granulation to overcome the disadvantages of Wet Granulation.
- 11. Swedish Ceramic Institute (SCI) has adopted and developed an alternative technique – freeze granulation (FG). It enables preservation of the homogeneity from suspension to dry granules. By spraying a powder suspension into liquid nitrogen, the drops (granules) are instantaneously frozen.
- 12. As the name suggests we will use foam binders such as METHOCEL polymers to improve binder distribution in the formulation mix and yields a remarkable array of processing advantages. A simple foam generation apparatus is used to incorporate air into a conventional watersoluble polymeric excipients binder such as METHOCEL hypromellose
- 13. 4. Melt Granulation Technology Principle of melt granulation:
- 14. Advancement in Equipment Technology Semiautomatic or fully automatic instrumentation system has been held in last decade to optimize each unit operation from granulation to compression. A. SPHERONIZERS B. MIXER-PROCESSOR &MIXER-GRANULATOR C. ALL-IN-ONE GRANULATION TECHNOLOGY
- 15. ADVANCEMENT IN COMPRESSION TECHNOLOGY OSDrC® OPTIDOSE TM (One-Step Dry-Coating) Single-step manufacturing opens the door to a host of new formulations • An innovative first-of-its-kind manufacturing process • Newly developed rotary punch tableting machine • Research and technical collaboration between pharmaceutical manufacturer and tableting machine manufacture
- 17. Outer layer forms sides and top Active pharmaceutical ingredients form core Outer layer forms base
- 18. OSDrC® OPTIDOSETM technology: Broad Range of Tablet Options: ● Bi-Layer Tablets ● Dividable Tablets ● IR/ER Combination Tablets ● Combination Products (multiple API in single tablets) ● Direct Compression Orally Disintegrating Tablets (ODT) Pulsatile Release Tablets
- 19. Thomas Tablet Sentinel(TTS) Thomas Tablet Sentinel(TTS)-2 Thomas Tablet Sentinel(TTS)-3 PH-800 Automated Tablet production system
- 23. A. FLUID BED OR AIR SUSPENSION COATING B.COMPRESSION COATING C. ELECTROSTATIC COATING D. GELCAP (GELATIN COATED CAPSULE SHAPED TABLETS)
- 24. Dria-coater, Hi-coater and Accelacoater. The Glatt-coater (cap. 25-1000 kg) is the latest perforated pan coater to be introduced in the market. Auto coaters (Granscoater) are available with software programmes and parameter setting Profiles. • NeoCota is the recent introduction of fully automated sugar and film coating system of tablets and pellets.
- 27. REFERENCES Remington.The science & practice of pharmacy,21st edition, vol-1. Leon Lachman,Lieberman AH,Kanig JL,the theory & practice of industrial pharmacy,4th edition. H.C.Ansel introduction to dosage forms. Michael E Aulton,Pharmaceutics science of dosage form design.2nd edition. Pharmaceutical dosage froms ,Tablets vol-1-3. Internet