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Rapid sequenceintubation venotheni ed
 The induction of a state of unconsciousness
with complete neuromuscular paralysis to
achieve intubation without interposed
mechanical ventilation in efforts to facilitate
the procedure and minimize risks of gastric
aspiration
 Assumptions made :
- patient not fasted
- patient not known / assessed to be difficult
intubation
Decreased
Aspiration !
Rapid sequenceintubation venotheni ed
Rapid sequenceintubation venotheni ed
Rapid sequenceintubation venotheni ed
Rapid sequenceintubation venotheni ed
 Evaluate
› LEMON
 Equipment Check – Mask – bag valve device, magills
forcep, endotracheal tubes,laryngoscope, lubricants,
different sizes of blades, airways, suction catheter, stylet,
stetoscope, syringe,
cricothyrotomy tray,
 Positioning
 Drug Selection – sedatives, paralysing agent
 IV’s, monitor – ECG, vitals, SpO2,
 Staff
 Anticipate alternative airway maneuver / difficult airway
 Anticipate difficult bag mask ventilation
 Anticipate vomitting 
- immediate suction with large bore Yankauer sucker
- lateral / recovery position
Rapid sequenceintubation venotheni ed
 LEMON assessment of
difficult airway
› L-look externally
› E-evaluate ‘2-3’ rule
› M-Mallampati score &
grade of laryngeal view :
Mallampati :- oropharygeal
visualisation
Cormack – Lehane :
laryngoscope grading
system
› O-Obstruction
› N-Neck mobility – sniffing
morning air position
Rapid sequenceintubation venotheni ed
 Mask Seal : bushy beard,
crusted blood on the face,
disruption of lower facial
continuity,
 Obesity, Obstruction :
obesity, pregnancy,
angioedema,upper airway
abscess,
 Age : > 55yrs old
 No teeth : consider leaving
dentures in
 Sleep apnea, stiff lung :
COPD, ARDS, asthma
Can I Bag this patient
?
Maybe
Maybe
not
Rapid sequenceintubation venotheni ed
Cormack – Lehane : laryngoscope grading system
Rapid sequenceintubation venotheni ed
 100% O2 for 5 minutes of 5 vital capacity
breaths can theoretically permit 3-5
minutes of apnea before desaturation to
less than 90% occurs
 “nitrogen wash-out”
 Avoid bagging the patient if adequately
preoxygenated
 Well fitted mask
Rapid sequenceintubation venotheni ed
 Goal is to blunt the patient’s physiologic
responses to intubation
 Minimizes bradycardia, hypoxemia,
cough/gag reflex, increases in
intracranial, intraocular, and intragastric
pressures
 Given 3 minutes prior to intubation
 Lidocaine
 Opioid
 Atropine
 Defasciculating doses “priming”
Rapid sequenceintubation venotheni ed
Rapid sequenceintubation venotheni ed
INDUCTION AGENTS
Etomidate
Ketamine
Propafol
Midazolam
PARALYTIC AGENTS
DEPOLARIZING
Succinylcholine
NON-DEPOLARIZING
Rocuronium
+
Induction agent (
Dosage)
Onset Full recovery (
duration )
Advantages Disadvantages Side Effect /
caution
Special uses
Midazolam
(0.1mg / kg )
30-60s 0.5 – 2hrs Amnestic sedative Hypotension
Suppresses
respiration, cvs
Etomidate (0.3mg
/ kg)
15 – 30sec 15 – 30min Cerebroprotective
Heamodynamic
stability
Rapid onset, short
duration
Nausea, vomiting,
pain on injection,
myoclonic
movements
Hiccups
Adrenal
suppression
Head injury
Hypotensive
patient
Ketamine (2mg /
kg)
15 – 30sec 15 – 30min Releases
cathecholamines
Analgesic
amnestic
Raised ICP Raised ICP Bronchospastic
patient
Hypotensive
patient WITHOUT
head injury
Heamodynamically
instability due to
cardiac
tamponade or
myocardial disease
Propofol (0.5 –
2.5mg / kg)
10 - 20sec 10-15min Decrease ICP
Rapid onset
Hypotension
Bradycardia
Rapid sequenceintubation venotheni ed
Neuromuscular Blocking Agents
 Chemical paralysis facilitates intubation
by allowing visualization of the vocal
cords and optimizing intubating
condition
 Only CONTRAINDICATION is anticipated
difficult airway
› Mallampati Class
› Thyromental Distance
Rapid sequenceintubation venotheni ed
 Onset : 45 sec, duration 8-10 min
 Dose: (adults :1.5 mg/kg IV,
Children 2.0 mg/kg IV
- Rapid onset,
- Eliminated independently of renal
excretion
 Muscle fasiculations
› Increase ICP/IOP
› Causes muscle pain
› Minimized by “priming”
dose of NMB
 Hyperkalemia
› Burns, crush injuries, spinal
cord injuries, neuromuscular
disorders, chronic renal
failure
 Bradycardia
› Most common in children
<10 years due to higher
vagal tone
 Malignant hyperthermia
› From excessive calcium
influx through open
channels
› Genetic predisposition
› Rapid temperature,
rhabdomyolysis, muscle
rigidity,
 Trismus (Masseter
spasm)
› Children, - Unknown
cause
› Treat with a
nondepolarizing NMB
 Has the shortest onset of the
nondepolarizing agents (1-3 min)
 Duration 30-45 min
 Tachycardia can occur
 Dose: 0.6-1.2 mg/kg
45 seconds ONSET 1 minute
9 minutes DURATION 45 minutes
1 mg/kg1-2.5 mg/kg
Rapid sequenceintubation venotheni ed
 Sellick’s Manoeuvre / application of
cricoid pressure – initiated immediately
upon obseration of patient losing
consciousness
 Positioned for laryngoscopy
Rapid sequenceintubation venotheni ed
Rapid sequenceintubation venotheni ed
 Tube placement confirmed with :
 - end tidal CO2 monitoring
 Clinical parameters: SpO2 monitoring, tube
condensation
 Cricoid pressure released after confirmation of
correct tube placement, endotracheal tube
secured
Rapid sequenceintubation venotheni ed
 Secure tube
 Continuous pulse oximetry
 Reassess vital signs frequently
 Obtain chest x-ray, ABG
 Restrain patient
 Consider long term sedation
Rapid sequenceintubation venotheni ed
 1. Emergency Medicine, Shirley Ooi
 2. Current Emergency medicine, Lange.
 3. Guideline For Resuscitation training,
NCORT
 4. Medscape

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Rapid sequenceintubation venotheni ed

  • 2.  The induction of a state of unconsciousness with complete neuromuscular paralysis to achieve intubation without interposed mechanical ventilation in efforts to facilitate the procedure and minimize risks of gastric aspiration  Assumptions made : - patient not fasted - patient not known / assessed to be difficult intubation Decreased Aspiration !
  • 7.  Evaluate › LEMON  Equipment Check – Mask – bag valve device, magills forcep, endotracheal tubes,laryngoscope, lubricants, different sizes of blades, airways, suction catheter, stylet, stetoscope, syringe, cricothyrotomy tray,  Positioning  Drug Selection – sedatives, paralysing agent  IV’s, monitor – ECG, vitals, SpO2,  Staff  Anticipate alternative airway maneuver / difficult airway  Anticipate difficult bag mask ventilation  Anticipate vomitting  - immediate suction with large bore Yankauer sucker - lateral / recovery position
  • 9.  LEMON assessment of difficult airway › L-look externally › E-evaluate ‘2-3’ rule › M-Mallampati score & grade of laryngeal view : Mallampati :- oropharygeal visualisation Cormack – Lehane : laryngoscope grading system › O-Obstruction › N-Neck mobility – sniffing morning air position
  • 11.  Mask Seal : bushy beard, crusted blood on the face, disruption of lower facial continuity,  Obesity, Obstruction : obesity, pregnancy, angioedema,upper airway abscess,  Age : > 55yrs old  No teeth : consider leaving dentures in  Sleep apnea, stiff lung : COPD, ARDS, asthma Can I Bag this patient ? Maybe Maybe not
  • 13. Cormack – Lehane : laryngoscope grading system
  • 15.  100% O2 for 5 minutes of 5 vital capacity breaths can theoretically permit 3-5 minutes of apnea before desaturation to less than 90% occurs  “nitrogen wash-out”  Avoid bagging the patient if adequately preoxygenated  Well fitted mask
  • 17.  Goal is to blunt the patient’s physiologic responses to intubation  Minimizes bradycardia, hypoxemia, cough/gag reflex, increases in intracranial, intraocular, and intragastric pressures  Given 3 minutes prior to intubation
  • 18.  Lidocaine  Opioid  Atropine  Defasciculating doses “priming”
  • 22. Induction agent ( Dosage) Onset Full recovery ( duration ) Advantages Disadvantages Side Effect / caution Special uses Midazolam (0.1mg / kg ) 30-60s 0.5 – 2hrs Amnestic sedative Hypotension Suppresses respiration, cvs Etomidate (0.3mg / kg) 15 – 30sec 15 – 30min Cerebroprotective Heamodynamic stability Rapid onset, short duration Nausea, vomiting, pain on injection, myoclonic movements Hiccups Adrenal suppression Head injury Hypotensive patient Ketamine (2mg / kg) 15 – 30sec 15 – 30min Releases cathecholamines Analgesic amnestic Raised ICP Raised ICP Bronchospastic patient Hypotensive patient WITHOUT head injury Heamodynamically instability due to cardiac tamponade or myocardial disease Propofol (0.5 – 2.5mg / kg) 10 - 20sec 10-15min Decrease ICP Rapid onset Hypotension Bradycardia
  • 24. Neuromuscular Blocking Agents  Chemical paralysis facilitates intubation by allowing visualization of the vocal cords and optimizing intubating condition  Only CONTRAINDICATION is anticipated difficult airway › Mallampati Class › Thyromental Distance
  • 26.  Onset : 45 sec, duration 8-10 min  Dose: (adults :1.5 mg/kg IV, Children 2.0 mg/kg IV - Rapid onset, - Eliminated independently of renal excretion
  • 27.  Muscle fasiculations › Increase ICP/IOP › Causes muscle pain › Minimized by “priming” dose of NMB  Hyperkalemia › Burns, crush injuries, spinal cord injuries, neuromuscular disorders, chronic renal failure  Bradycardia › Most common in children <10 years due to higher vagal tone  Malignant hyperthermia › From excessive calcium influx through open channels › Genetic predisposition › Rapid temperature, rhabdomyolysis, muscle rigidity,  Trismus (Masseter spasm) › Children, - Unknown cause › Treat with a nondepolarizing NMB
  • 28.  Has the shortest onset of the nondepolarizing agents (1-3 min)  Duration 30-45 min  Tachycardia can occur  Dose: 0.6-1.2 mg/kg
  • 29. 45 seconds ONSET 1 minute 9 minutes DURATION 45 minutes 1 mg/kg1-2.5 mg/kg
  • 31.  Sellick’s Manoeuvre / application of cricoid pressure – initiated immediately upon obseration of patient losing consciousness  Positioned for laryngoscopy
  • 34.  Tube placement confirmed with :  - end tidal CO2 monitoring  Clinical parameters: SpO2 monitoring, tube condensation  Cricoid pressure released after confirmation of correct tube placement, endotracheal tube secured
  • 36.  Secure tube  Continuous pulse oximetry  Reassess vital signs frequently  Obtain chest x-ray, ABG  Restrain patient  Consider long term sedation
  • 38.  1. Emergency Medicine, Shirley Ooi  2. Current Emergency medicine, Lange.  3. Guideline For Resuscitation training, NCORT  4. Medscape