Higher-order clustering coefficients generalize the clustering coefficient to capture clustering with respect to larger cliques (denser subgraphs) beyond triangles. The speaker defines higher-order clustering coefficients as the fraction of (r-1)-cliques paired with an adjacent edge that induce an r-clique. These coefficients reveal that real-world networks exhibit clustering to different orders and provide additional insights into network structure compared to only considering triangles. The coefficients also vary across networks such as neural, social, and collaboration networks in ways not explained by random graph models.