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OS18
Global Vaccine Security
Why it matters for the progressive control of FMD
Keith Sumption
OS18
Vaccine security –the concept
"Food security exists when all people, at all times, have physical, social
and economic access to sufficient, safe and nutritious food which
meets their dietary needs and food preferences for an active and
healthy life. Household food security is the application of this concept
to the family level, with individuals within households as the focus of
concern (FAO, 2003) "
Vaccine Security
…..people, at all times have physical, social and economic access to
sufficient, safe and effective vaccines to meet their needs and of the
livestock in their care……
OS18
Vaccine security
UNICEF
Vaccine security requires the guaranteed production of vaccines,
secures multi-year allocations for vaccine financing, the development of
long-term forecasting of vaccine requirements and helps reduce
wastage.
The context here is the secure delivery of international vaccine campaigns by national health
services.
In livestock production, who is our focus ? Who is in need of vaccine
SECURITY ?
OS18
FMD CONTEXT (2018)
Non –free (Endemic): Africa, Asia, Mid-East
Free countries (70), countries with free zones (19)
Global large ruminants 1,782 MILLION:
~ One billion of these are in FMD
endemic countries
[Hundreds of millions of owners]
X 1.7
billion
OS18
Global burden of FMD
• estimated that around 2% of the world's cattle population has FMD in
a year (90% uncertainty range: 2–5%)
• Global estimate of 32 million livestock units (LSU) are affected by FMD
in a year (but maybe >250 million*)
• Frequent and high risk disease for cattle producers in endemic regions
• Global demand for FMD vaccine (→Session 2)
• based on serological surveys compared to reported cases
OS18
Annual FMD loss per head : much higher in non-free
countries
FMD - country
status
Total Cattle and
Buffaloes
Impact (2012)
per annum
Loss per
head/annum
FREE 836 million US$ 1.5 billion USD 1.79
NOT-Free 946 million US$ 11 billion USD 11.6
Livestock data (2015) from FAOSTAT. Impact figures 2012 (from Knight-Jones and Rushton, 2013) were for all species
So the impact of 11.6 USD per head LR will be an overestimate
OS18
Some history: how we were : 2002-2008
June 2002 :
• International Symposium on FMD
Control Strategies (OIE/IABS, Lyon)
Agreed upon:
• The need for regional programmes to control FMD
Gaps:
• Very little quantitation of impacts
• Weak arguments to achieve investment
• Lack of institutional framework (FAO/OIE )
• Lack of framework for strategic planning
• Lack of solutions appropriate to endemic regions
OS18
Climbing enormous mountains is
best done in stages
On FMD:
2007-8: Seven virus pools concept – defines regions at common risk
2008 : Progressive Control Pathway for FMD (PCP) first applied
2009: OIE/FAO Global Conference , Paraguay
-supports development and evaluation of the PCP
-FMD control - national responsibilities , public good
2011: PCP-FMD as a Joint Tool, Global FMD Working Group
established
2003- HPAI Crisis
2004- GF-TADS and FAO: OIE
Agreement
2005- Increasing regional
GfTADS meetings, PVS…
Erice, Open
Session 2008
OS18
Key recommendations -Erice (OS 08)
 Surveillance: to follow an Ecosystem approach : Virus Pools →informatics→ inform Regional Roadmaps
 Diagnostics: optimize protocols for transporting inactivated FMDV between field and National and International RLs
 National action as part of Regional Roadmaps →→Global Progress
 Promote “”Progressive””, risk based approach at national level, plans to focus on “critical control points””
 Vaccination:
 optimize by targeting to risks
 OIE/FAO Reference Centres → Annual Guidance Report per pool
 New vaccines: empty capsids “”should be pursued””
 Global Strategy needs a new approach to Global Progress Measurement:
 Global Risk Report at least 2x per year (OIE/FAO)
 Multi-agency, Systematic, Global surveys to measure “’real progress to reduce incidence””
 Global strategy to place emphasis on moniutoreing efficacy of vaccination programmes
 Financial strategy
 key element of public - private sector co-operation to pay for vaccinations
 Biosecurity Agenda - must be placed much higher given the lack of vaccines
 Strategy for Regional and Global Control
 Ecosystems approach : 7 pools
 Regional workshops to develop longer term regional strategies (Roadmaps)
 FAO and OIE to address how increased investment/financing can be achiedd with high buy-in from stakeholders
 Socio-economic issues preventing stakeholder investment must be addressed
 Annual Global Report covering virological, epidemiological and programmatic progress in every region
OS18
Key recommendations -Erice (OS 08)
 Surveillance: to follow an Ecosystem approach : Virus Pools →informatics→ inform Regional Roadmaps
 Diagnostics: optimize protocols for transporting inactivated FMDV between field and National and International RLs
 National action as part of Regional Roadmaps →→Global Progress
 Promote “”Progressive””, risk based approach at national level, plans to focus on “critical control points””
 Vaccination:
 optimize by targeting to risks
 OIE/FAO Reference Centres → Annual Guidance Report per pool
 New vaccines: empty capsids “”should be pursued””
 Global Strategy needs a new approach to Global Progress Measurement:
 Global Risk Report at least 2x per year (OIE/FAO)
Х Multi-agency, Systematic, Global surveys to measure “’real progress to reduce incidence””
 Global strategy to place emphasis on monitoring efficacy of vaccination programmes
 Financial strategy
Х key element of public - private sector co-operation to pay for vaccinations
Х Biosecurity Agenda - must be placed much higher given the lack of vaccines
 Strategy for Regional and Global Control
 Ecosystems approach : 7 pools
 Regional workshops to develop longer term regional strategies (Roadmaps)
Х FAO and OIE to address how increased investment/financing can be achieved with high buy-in from stakeholders
Х Socio-economic issues preventing stakeholder investment must be addressed
Х Annual Global Report covering virological, epidemiological and programmatic progress in every region
OS18
10 years after the Erice Open Session: how did we
do?
Surveillance: to follow an Ecosystem
approach : Virus Pools →informatics→
inform Regional Roadmaps (→Keynote:
Don King)
Х Diagnostics: optimize protocols for
transporting inactivated FMDV between
field and National and International RLs
(→ANSES, Session 5A, Day 2)
OS18
OS08 Recommendations towards a global
approach
National action as part of Regional
Roadmaps →→Global Progress
Promote “”Progressive””, risk based
approach at national level, plans to
focus on “critical control points””
• Concept introduced at Erice, 2008
• 1st applied to develop the West Eurasia
Roadmap (Shiraz 2008)
The PCP concept as 1st proposed: 2008
Keith Sumption, Juan Lubroth and Jemi Domenech
OS18
The Progressive movement
• PCP – FMD : 2008
• Tested in Roadmaps and in national application, 2009-10
• 1st Joint PCP Guidelines, 2011
• Cornerstone of the Global FMD Strategy 2012
• 2nd Edition Guidelines 2018
• Joint EuFMD/FAO/OIE
• 72 countries on the Pathway (about half still in Stage 1, though..)
• Assists national processes for mid-long term strategy development
• Associated tools for self-assessment of progress
• GF-TADS processes in place for regional validation of progression or
reversion
OS18
The PCP for FMD (the pioneer …first risk management
framework in animal health)
• 1st PCP Guidelines, 2011 2nd PCP Guidelines, 2018
• Joint EuFMD/FAO/OIE
OS18
PCP – stepwise along the road
 Country Stages -
facilitate progress
monitoring
 at national and
regional level
 Global scale -across
Regional Roadmaps
 and at every stage generates
information for risk
assessment
OS18
PCP early days…
This is how it felt working “”progressively”” with countries!!
OS18
This is also how it felt at times - ! 2008-11
OS18
2011: One Framework – from endemic to free
without vaccination. In achievable Stages.
Stage 3: option to
apply for OIE
endorsed National
FMD Control
programme
OIE
recognition
and
endorsement
options
Getting
started:
Policy ,
Strategy,
Implementation
Monitoring
Evaluation
OS18
PCP-FMD
2nd edition of guidelines
OS18
West Eurasia Roadmap
Outcome Criteria Questions
COMPLETE THIS
COLUMN
Yes=1 , No=0
Not applicable=NA,
Yellow = enter a
number
Outcome 1
All husbandry systems,
the livestock marketing
network and associated
socio-economic drivers
are well described for
FMD susceptible species
Animal
movements
are
understood
"Thoroughly described" means information is be available about
numbers, origin and destination, reasons (drivers or motives) for the
movement and any seasonal patterns
1.1 Are the movements of the key livestock species thoroughly described?
1.2 Are movements of cattle within the country thoroughly described?
1.3
Are movements of small ruminants within the country thoroughly
described?
1.4 Are movements of swine within the country thoroughly described?
1.5 Are movements of cattle into the country thoroughly described?
1.6
Are movements of small ruminants into the country thoroughly
described?
1.7 Are movements of swine into the country thoroughly described?
1.8
If there is transhumance or nomadic peoples, are the associated
animal movement patterns thoroughly described?
Stakeholders
and incentives
Stakeholders include farmers/producers PLUS all of the main players
(people,organizations,companies) involved in breeding, transport of
animals, milk/meat processing, feeding and marketing of animals.
1.9
Have key stakeholder categories involved in cattle production been
identified?
1.10
Have key stakeholder categories involved in small ruminant production
been identified?
1.1
Have key stakeholder categories involved in swine production been
identified?
OS18
23
Assessed Foreseen
Countries 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025
Afghanistan (absent in Bishkek) 0 1 1 1 1 1 1 1 1 1 2 2 2 2 3 3 3 4
Armenia 2 2 2 2 2 2 2* 2* 2 2 3 3 3 3 4 4 5 5
Azerbaijan 2 2 2 2 2 2 2* 2* 2 2 3 3 3 3 3 3 4 4
Georgia 2 1 1 1 1 1 2* 2 2 2 3 3 3 3 4 5 5 5
Iran 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 4 4 4
Kazakhstan (5 southern regions) 1 1 1 1 1 1 2* *** ***
Kazakhstan (9 norther regions) 1 1 1 1 1 1 2* ** 5 5 5 5 5 5 5 5 5 5
Kyrgyzstan 1 0 0 0 1 1 2* 2* 2* 3 3 3 4 4 5 5 5 5
Pakistan 0 1 1 1 1 1 2* 2 2 2 2 3 3 3 3 3 4 4
Tajikistan 0 1 1 1 1 1 1 1 1 2 3 3 4 4 4 4 4 4
Turkey (Thrace) 5 5 5 5 5 5 5 5 5 5
Turkey(Anatolia/Marmara-Aegean) 2 3 3 4 4 4 4 4 5 5
Turkey (Remaining Anatolia) 1 2 2 2 2 2 2 2 2 2 2 2 2 3 3 4 4 4
Turkmenistan 0 0 0 0 1 1 1 1 1 2 2 2 2 3 3 4 4 5
Uzbekistan (absent in Bishkek) 0 1 1 1 1 1 1 1 1 2 3 3 3 4 4 5 5 5
Assessed by RAG Middle-East
Iraq 1 1 1 1 1 2* 2* 2*
Syria 1 1 1 1 1 2* 2* 2*
0
2
4
6
8
10
2012 2016
10
44
8
2
NO.COUNTRY
stage 1
stage 2
stage 5
12-14 countries West Eurasia
OS18
Eastern Africa Roadmap
Vision for the Eastern Africa Roadmap for FMD control:
• “An East African region in which FMD will be under control and approaching disease
freedom (PCP-FMD Stage 3) in the majority of member states by 2020, with zonal or
country freedom (PCP-FMD Stage 4) being reached in some parts of the sub region””
OS18
SAARC Regional Roadmap meeting
FAO-ICAR FMD conference
OS18
Components of the FMD Global Strategy
(FAO/OIE, 2012)
1 Improve global FMD control
2 Strengthening veterinary services
3 Improving the prevention and control of
other major diseases of livestock
OS18
Global Regional National
GF-TADs FMD WG Developed the
GS and coordinates its
implementation
Regional roadmap meetings for
country assessment and capacity
building
Use of PCP-FMD guidelines as
tool for implementation
Strength Veterinary Services
Support other TADs
Global Network:
• Network of FAO/OIE FMD
Reference Lab
• Global Expert Group
Support regional laboratory and
epidemiology networks
+ meetings
Countries’ investment and control
plans (FAO, OIE, EuFMD and
donor support)
Development of resource
documents
Regional proficiency test panels Performance of veterinary
services (PVS)
Promote regional collaboration and
transparency, including cross border
issues
Promotion of success stories and
in country support.
FMD Global Strategy:
Global, Regional and National application
OS18
28
PHEFA
SEAC
FMD
Pools 2-5
19 Roadmap meetings
3
2
6
4
5
7
1
Regional : addressing the 7 Ecosystems
Regional Roadmap Meetings Convened
Since 2012
OS18
Progressive control in the endemic regions
: FMD Global Map 2012 & 2017
The PCP is a framework for risk management - with 3 stages before entry into the OIE recognition
system
BUT:
Rates of
Progress differ
between
regions
OS18
One Pathway ( No to be mistaken for One Road, One Belt )
http://www.gf-tads.org/fmd/progress-on-fmd-control-strategy/en/
OS18
The Progressive movement
• Completely new approach that has
been taken up Global control of
PPR, rabies, African
trypanosomoses, …
• PCP for brucellosis control in
pipeline (end 2018)
• Progressive “”management””
pathways
• adaption to AMR and aquaculture
health
OS18
PCP toolkit : Self-Assessment of achievement
Plan to study of
epidemiological and soc-
economics
1. Value chain analysis
2. FMD distribution &
hypothesis
3. Socio-economic
impact
4. Circulating strains
5. Strengthening
Veterinary Services
6. Commitment to
regional approach
7. Identification of
"Hotspots"
8. Strategic FMD control
plan
Country's percentage achievement totally Minimum requirements for fulfiling Stage 1
Percentage achievement-required
Checklist
–Y/N
-Not
applicabl
e
To enter Stage 1 1.1
Is there a written plan in place to study the
epidemiology and socioeconomic impact of
FMD?
1
1.2
Does the plan include a study of the structure of
livestock production throughout the country for
all FMD susceptible species (cattle, sheep,
goats)?
0
To have a comprehensive plan to
study epidemiology and socio-
economicsof FMD
1.3Does the plan include activities to estimate FMD
prevalence? 1
1.4Does the plan include a timeline for activities?1
1.5Does the plan include a budget estimate for each
activity? 1
1.6
Does the plan describe the organisational
structure to carry out the study (defined roles
and responsibilities, nominated persons)
1
1.7Have any of the activities described in the plan
been initiated? 1
Stake holders include farmers/producers PLUS
all of the main players
(people,organizations,companies) involved in
breeding, transport of animals, milk/meat
processing, feeding and marketing of animals.
There could be scoring for these questions:
identified all, most, some, none
Outcome 1 1.8Have key stakeholders involved in cattle
production been identified? 0
1.9Have key stakeholders involved in small
ruminant production been identified? 0
All husbandry systems, the
livestock marketing network and
associated socio-economic drivers
are well described for FMD
susceptible species
1.1Have key stakeholders involved in swine
production been identified? 0
Information should be available about
numbers, origin and destination, drivers or
motives for the movement and any seasonal
patterns there could be scoring based on how
completely movements have been described
(eg origin and destination known but not
numbers, or for commercial farms only...)
1.1Are movements of animalswithin the country
well understood for cattle? 0
1.1Are movements of animalswithin the country
well understood for small ruminants? 0
1.1Are movements of animalswithin the country
well understood for swine? 0
1.1Are movements of animalsinto the countrywell
understood for cattle? 0
1.2Are movements of animalsinto the countrywell
understood for small ruminants? 0
1.2Are movements of animalsinto the countrywell
understood for swine? 0
1.2If there is transhumance or nomadic peoples,
are their movement patterns understood?0
Outcome Criteria Questions
Plan is
comprehensive
Quality indicators
stakeholders
movements
OS18
PCP self-assessment online tool (2018, EuFMD/OIE/IZSLT)
PCP tool team: Chris Bartels (EuFMD), Gregorio Torres (OIE), Giancarlo Ferrari (IZLST), Excel development: Tiziano Federici, Manuel Ajerbe Posada, Alessandra Alviti (EuFMD)
Website: Andrea Vitelli (IZLST), Giancarlo Ferrari (IZLST)
OS18
Progress on The PCP-FMD
• Almost entirely funded by national programmes!
• Assisted countries with internal processes of strategy development
• International funding : Roadmaps (FAO and OIE co-fund)
• Technical support:
• Initially by FAO /EuFMD projects, later OIE projects (SEACFMD+..)
• no PCP army or full time PCP officers ..a but “small company”” of PCP experts
act as national support officers (2018, →Nick Lyons, EuFMD/TPI)
• Suite of e-learning tools – open access (2016-)
• PCP community - Network of PCP Practitioners (2016-18) (→Chris Bartels)
OS18
How did we do on other OS08 recommendations?
Vaccination:
optimize by targeting to risks –
introduced to national planning
(PCP)
Production systems need
different vaccination
programmes
Chris Bartels & Melissa McLaws
Iran – PCP Stage 1 project
OS18
OS08 and vaccination
Vaccination:
optimize by targeting to risks – introduced to national planning (PCP)
OIE/FAO Reference Centres → Annual Guidance Report per pool (from 2010)
OS18
PCP early day push backs on vaccination
• FMD eradication camp concept of “”control means total control””
(nothing is under control until everything is under control)
• Compared to “”control begins at the epi-unit”” (farm, village..)
• Thus:
• Its useless to do anything unless you achieve 80%+ vaccination cover
• Vs
• “”Good immunity protects against disease at animal and epi-unit
scale ..and can give immediate benefits””
OS18
Erice 0S08 - new vaccines
What did we do?
• New vaccines: empty capsids
“”should be pursued”” (→Session
7, Day 2)
• GFRA members – carrying the
torch in the darkness
• Day 2 :
• improving conventional vaccines
• recombinant and attenuation (LL -
Leaderless) vaccines
• Improving master seed viruses
OS18
OS08 and Measuring progress
 Global Strategy needs … Global Progress Measurement:
 Global Risk Report at least 2x per year (OIE/FAO)
 Monthly Global Reports (EuFMD), Quarterly (WRL) and Annual (OIE/FAO FMD network)
Х Epidemiological evidence - to measure “’real progress to reduce incidence””
Х Guidance was to focus on PCP process indicators NOT actual health (%NSP+..)
 However as PCP was rolled out, sero-survey data 2008-12 allowed revised estimates of
global FMD burdens and impacts (Knight-Jones & Rushton, 2013; Knight-Jones, McLaws & Rushton 2017)
 Global strategy to place emphasis on monitoring efficacy of vaccination programmes
 Post-Vaccination Monitoring (PVM) Guidelines, FAO/OIE
 Associated e-learning courses and workshop training (EuFMD, WRL, IZS) (→Session 8)
Х Thus : currently NO Annual Global Report combining virological ,
epidemiological and programmatic (PCP) progress in every region
Х Separate virological and programmatic reports
Х No systematic epi-report or vaccination reports
GAP
OS18
What did we do after OS08?
Strategy for Regional and Global Control
Ecosystems approach : 7 pools
Regional workshops to develop longer term regional strategies (Roadmaps)
BUT…
Х FAO and OIE to address how increased investment/financing can be achieved
with high buy-in from stakeholders
Х Until 2017 : OIE/BMGF Initiative on PPP but focus on services - not financing
Х Socio-economic issues preventing stakeholder investment must be addressed
Х Identified in Stage 1- PCP but issues difficult to address in endemic regions
OS18
Imagine if the people
Controlled their own PCP
Standing on their own feet
Sharing responsibility
You may say I’m a dreamer
[I hope am not the only one]
OS18
Lets be honest…What did we NOT do?
• Address the fundamentals
• Who pays?
• Who takes responsibility?
• You cannot vaccinate, without vaccine
• Transform vaccine availability
• Change enough minds on
investment
• Mainstream PCP into development
agendas (World Bank projects etc)
OS18
FMD control – who should pay for it?
• Public good?
• Vaccination to prevent a contagious
disease
• Defending borders against entry
• Response and elimination of
incursions
• Private good?
• FMD prevention as part of good
production practice – the owner is
the main economic beneficiary
OS18
Issues for privatizing FMD vaccination – endemic countries
• Policy : Can disease be controlled at herd level even if
neighbours do not vaccinate
• Supply issue: availability of quality vaccines LOW
• Market development needs information !
• PPP – needs enabling environment for private uptake
of vaccination
• Experience/Risk tolerance of livestock owners
No product
on market
Disease
uncontrolled
Living with
losses
Lack of
market
demand for
vaccine
Vaccine not
produced
for Africa
OS18
Working better together? public, private and industry
Public
services
•National FMD strategies
•Prevention programmes
•Enabling environment for health
service delivery
•Surveillance, Regulate and enforce
•Register vaccines
Private
sector
animal
health
•Herd level prevention and treatment
services
•Major option for service delivery
(vaccination)
•Maybe impeded by state actors from
delivering services
•Role of paravets
Livestock
industry
•Animal wealth is in private hands
•Potential for co-management of
FMD issues with Government
•Many players, may lack cohesive
voice
•Potential to establish management
based high-health compartments
with
Often weak, unsupportive
(endemic regions)
Private sector often impeded from providing
services on FMD
lack access to quality vaccines or risk
information for preventive plans
Potential to drive change -
if enabled to work with
Government actors
OS18
VACCINE Security is not
equal
Why should the
FMD FREE COUNTRIES
have the good
VACCINE?
CAN VACCINE BANKS BECOME PART OF THE
GLOBAL SOLUTION?
AESOP
→Day 3 Break-out Session
OS18
Assured Emergency Supply OPtions (AESOP)
- may increase supply for FMD emergencies
EuFMD Feasability study -2017/18
A new, potential
additional option
for access to
vaccines in
emergencies
→Break-out: Day
3
OS18
Keith’s
Emphasis on the Vaccine Availability Notion
OS18
Reaching out for a
solution
OS18
Why can’t livestock owners access FMD
vaccines when they need them?
MD
OS18
Money is often NOT the problem. There are
other barriers
And
FMD
VACCINES
→Session 2: Demand
→Session 3 and 4 : supply and barriers
OS18
Imagine…
What would vaccine
availability look like… And Google was to tell vaccine
buyers whats available near you?
If Amazon was to manage
delivery?
“ALEXA, find
vaccines for
tomorrow””
OS18
Vaccine availability: why don’t we talk about
it?
• Its just too huge!!!!
• so no one is talking about it
• Why?
• The needy are not in charge..
• PPP avoidance
• Reluctance of international bodies to
engage with private sector/pharma?
• No equivalent of GAVI for animal
health?
• Or?
OS18
Elephantine rumblings
• Session 2: Demand:
• Session 3: Supply:
• Session 4: Breaking barriers
• Session 5: Informatics for selection of
vaccines
• Session 6: Championing conventional vaccines
• Session 7: Championing the new platforms
• Session 8: Discussion on attenuated vaccines,
and
• 8B Directions in Vaccination Programme
monitoring
• Day 3 sign –up sessions
• If you DON’T want to talk vaccines
• Parallel sessions
• Virology and immunopathogenesis
• Modelling FMD transmission
• Biosecurity and business continuity
• Break-outs planned for Day 3
• Regional epidemiology
• Diagnostic developments
• Modelling regional spread (EuFMDis)
OS18
Vaccine Security and the EuFMD workplan 2015-2019
Components
1.1 – Training for Member States
1.2 – Improved Contingency Planning
1.3 - Improved surveillance and management
in Thrace
1.4 - improve emergency management
capacity for FMD in the Balkan region
1.5 - FAR - Fund for Applied Research
1.6 - Emergency technical responses
1.7 - Proficiency test scheme
1.8 - Risk Analysis and Communication
OS18
Training for Member States
Training opportunities:
Training is selected based on the EuFMD
Training Menu and NTFP allocations;
388 Training Credits available to MSs
The EuFMD e-Learning Virtual Learning
Environment (VLE) now has over 7300 users,
with 1600 new users added in the last six
months.
The online EuFMD Knowledge Bank is a
searchable database of FMD related
resources. And now contains over 450
resources and over 80 webinar recordings
1) Real Time Training
2) Online FMD Emergency Preparation Course:
for multiple Member States in English
3) Online FMD Emergency Preparation Course:
Tailored National Course Online course in
national language,
4) Online FMD Emergency Preparation Course:
subsequent national course
5) Workshop: “Managing a crisis”
6) Workshop: “FMD Simulation exercises”
7)Workshop:“Putting vaccination into practice”
8) Workshop: “FMD Wildlife surveillance”
9) Workshop: “Veterinary Ethics”
10) In-country support on FMD modelling
11) Laboratory Training Course
12) Regional event:
Biorisk Training in collaboration with TPI
OS18
Vaccine Security and European neighbourhood programme 2015-2019
Components
2.1 – South East Europe
2.2 - South East Mediterranean
2.3 - Support to REMESA
2.4 -Training development and coordination
OS18
Pillar II: Reduced FMD risk to Members from European
neighbourhood
1.Progression along PCP
2.Improve assessment of risk *
3.Implementation of risk based
strategies (surveillance, vaccination, …)
4. Improved national capacity for
FMD management (capacity
building)
Targets across the pillar
OS18
 Training on Safe Trade and FMD control
RECENT COURSES DEVELOPED
 Training on Containment zones
 FMD surveillance and Post Vaccination
Monitoring
In progress
OS18
Vaccine Security as a global issue > not directly addressed
Components
3.1 - Improved system for monitoring and
evaluation of progress of regional
programmes on FMD control
3.2 – Support to Global Progress
Monitoring of FMD Control programmes
3.3 - Laboratory support
3.4 – Global access to PCP-FMD training
resources
OS18
PCP Support Officers
• DESK support to 25 countries
• Guidance on PCP stage advancement and maintain momentum between roadmap
meetings
• Work with national PCP focal points and relevant regional FAO and OIE offices to provide
guidance on PCP progression
• System has been agreed by the FAO-OIE working group
OS18
What I said at OS08, I believe more than
ever…
OS18
Progress yes −but the challenge remains to
transform the daily reality of millions
• Needs a massive upscaling in access to information, services – and vaccines
• New focus on the First Mile/Last Mile is encouraging
• Needs upscaling in vaccine supply
• unmet demand must translate into sustained supply
• MAJOR private sector investment and MAJOR public sector policy support needed
• And Recognition that this is a common problem affecting multiple, preventable TADS
• Vaccine security affects us all!
OS18
Global issues – affecting prospects of progress
Increasing Global security in the supply of effective
FMD vaccines: can we really manage the risks and
achieve progressive FMD control without it?”
OS18
1. Global vaccine security : a useful concept? - means the assurance that
sufficient and suitable vaccine is available at point of need
2. With assured supply, quality not availability would be the deciding factor
3. The scale of change needed demands a new approach - a global PPP for
vaccine security
66
Regardless of where you live,
global vaccine security matters
(Keith Sumption, 2017) .
Global vaccine insufficiency (insecurity) -
affects us all?
Thank you
OS18
Acknowledgements > we could not have done this
without all our progressive friends and colleagues
• Nadia Rumich
• Enrique Anton
• Carsten Potszch, Giancarlo Ferrari *FAO, IZS, Juan
Lubroth
• Chris Bartels
• Melissa McLaws
• Nick Lyons
• David Paton
• Fabrizio Rosso
• Jenny Maud
• Cecile Carraz and the whole Operations Team
• EuFMD Presidents Peter de Leeuw, Ulrich Herzog,
Jean-Luc Angot
• National PCP Focal points
• Don King, WRL FMD, TPI and the OIE/FAO
network
• FAO (Samia Metwally, Julio Pinto, Peter de
Leeuw)
• OIE (Laure Weber-Vintzel, Gregorio Torres,
Djahne Montabord)
• EC DG SANTE (Alf Fuessel, B v Goethem)
• Resource Partners for FAO and OIE PCP
programmes
• And hundreds more….

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OS18 - 1.1 Global Overview - K. Sumption

  • 1. OS18 Global Vaccine Security Why it matters for the progressive control of FMD Keith Sumption
  • 2. OS18 Vaccine security –the concept "Food security exists when all people, at all times, have physical, social and economic access to sufficient, safe and nutritious food which meets their dietary needs and food preferences for an active and healthy life. Household food security is the application of this concept to the family level, with individuals within households as the focus of concern (FAO, 2003) " Vaccine Security …..people, at all times have physical, social and economic access to sufficient, safe and effective vaccines to meet their needs and of the livestock in their care……
  • 3. OS18 Vaccine security UNICEF Vaccine security requires the guaranteed production of vaccines, secures multi-year allocations for vaccine financing, the development of long-term forecasting of vaccine requirements and helps reduce wastage. The context here is the secure delivery of international vaccine campaigns by national health services. In livestock production, who is our focus ? Who is in need of vaccine SECURITY ?
  • 4. OS18 FMD CONTEXT (2018) Non –free (Endemic): Africa, Asia, Mid-East Free countries (70), countries with free zones (19) Global large ruminants 1,782 MILLION: ~ One billion of these are in FMD endemic countries [Hundreds of millions of owners] X 1.7 billion
  • 5. OS18 Global burden of FMD • estimated that around 2% of the world's cattle population has FMD in a year (90% uncertainty range: 2–5%) • Global estimate of 32 million livestock units (LSU) are affected by FMD in a year (but maybe >250 million*) • Frequent and high risk disease for cattle producers in endemic regions • Global demand for FMD vaccine (→Session 2) • based on serological surveys compared to reported cases
  • 6. OS18 Annual FMD loss per head : much higher in non-free countries FMD - country status Total Cattle and Buffaloes Impact (2012) per annum Loss per head/annum FREE 836 million US$ 1.5 billion USD 1.79 NOT-Free 946 million US$ 11 billion USD 11.6 Livestock data (2015) from FAOSTAT. Impact figures 2012 (from Knight-Jones and Rushton, 2013) were for all species So the impact of 11.6 USD per head LR will be an overestimate
  • 7. OS18 Some history: how we were : 2002-2008 June 2002 : • International Symposium on FMD Control Strategies (OIE/IABS, Lyon) Agreed upon: • The need for regional programmes to control FMD Gaps: • Very little quantitation of impacts • Weak arguments to achieve investment • Lack of institutional framework (FAO/OIE ) • Lack of framework for strategic planning • Lack of solutions appropriate to endemic regions
  • 8. OS18 Climbing enormous mountains is best done in stages
  • 9. On FMD: 2007-8: Seven virus pools concept – defines regions at common risk 2008 : Progressive Control Pathway for FMD (PCP) first applied 2009: OIE/FAO Global Conference , Paraguay -supports development and evaluation of the PCP -FMD control - national responsibilities , public good 2011: PCP-FMD as a Joint Tool, Global FMD Working Group established 2003- HPAI Crisis 2004- GF-TADS and FAO: OIE Agreement 2005- Increasing regional GfTADS meetings, PVS… Erice, Open Session 2008
  • 10. OS18 Key recommendations -Erice (OS 08)  Surveillance: to follow an Ecosystem approach : Virus Pools →informatics→ inform Regional Roadmaps  Diagnostics: optimize protocols for transporting inactivated FMDV between field and National and International RLs  National action as part of Regional Roadmaps →→Global Progress  Promote “”Progressive””, risk based approach at national level, plans to focus on “critical control points””  Vaccination:  optimize by targeting to risks  OIE/FAO Reference Centres → Annual Guidance Report per pool  New vaccines: empty capsids “”should be pursued””  Global Strategy needs a new approach to Global Progress Measurement:  Global Risk Report at least 2x per year (OIE/FAO)  Multi-agency, Systematic, Global surveys to measure “’real progress to reduce incidence””  Global strategy to place emphasis on moniutoreing efficacy of vaccination programmes  Financial strategy  key element of public - private sector co-operation to pay for vaccinations  Biosecurity Agenda - must be placed much higher given the lack of vaccines  Strategy for Regional and Global Control  Ecosystems approach : 7 pools  Regional workshops to develop longer term regional strategies (Roadmaps)  FAO and OIE to address how increased investment/financing can be achiedd with high buy-in from stakeholders  Socio-economic issues preventing stakeholder investment must be addressed  Annual Global Report covering virological, epidemiological and programmatic progress in every region
  • 11. OS18 Key recommendations -Erice (OS 08)  Surveillance: to follow an Ecosystem approach : Virus Pools →informatics→ inform Regional Roadmaps  Diagnostics: optimize protocols for transporting inactivated FMDV between field and National and International RLs  National action as part of Regional Roadmaps →→Global Progress  Promote “”Progressive””, risk based approach at national level, plans to focus on “critical control points””  Vaccination:  optimize by targeting to risks  OIE/FAO Reference Centres → Annual Guidance Report per pool  New vaccines: empty capsids “”should be pursued””  Global Strategy needs a new approach to Global Progress Measurement:  Global Risk Report at least 2x per year (OIE/FAO) Х Multi-agency, Systematic, Global surveys to measure “’real progress to reduce incidence””  Global strategy to place emphasis on monitoring efficacy of vaccination programmes  Financial strategy Х key element of public - private sector co-operation to pay for vaccinations Х Biosecurity Agenda - must be placed much higher given the lack of vaccines  Strategy for Regional and Global Control  Ecosystems approach : 7 pools  Regional workshops to develop longer term regional strategies (Roadmaps) Х FAO and OIE to address how increased investment/financing can be achieved with high buy-in from stakeholders Х Socio-economic issues preventing stakeholder investment must be addressed Х Annual Global Report covering virological, epidemiological and programmatic progress in every region
  • 12. OS18 10 years after the Erice Open Session: how did we do? Surveillance: to follow an Ecosystem approach : Virus Pools →informatics→ inform Regional Roadmaps (→Keynote: Don King) Х Diagnostics: optimize protocols for transporting inactivated FMDV between field and National and International RLs (→ANSES, Session 5A, Day 2)
  • 13. OS18 OS08 Recommendations towards a global approach National action as part of Regional Roadmaps →→Global Progress Promote “”Progressive””, risk based approach at national level, plans to focus on “critical control points”” • Concept introduced at Erice, 2008 • 1st applied to develop the West Eurasia Roadmap (Shiraz 2008) The PCP concept as 1st proposed: 2008 Keith Sumption, Juan Lubroth and Jemi Domenech
  • 14. OS18 The Progressive movement • PCP – FMD : 2008 • Tested in Roadmaps and in national application, 2009-10 • 1st Joint PCP Guidelines, 2011 • Cornerstone of the Global FMD Strategy 2012 • 2nd Edition Guidelines 2018 • Joint EuFMD/FAO/OIE • 72 countries on the Pathway (about half still in Stage 1, though..) • Assists national processes for mid-long term strategy development • Associated tools for self-assessment of progress • GF-TADS processes in place for regional validation of progression or reversion
  • 15. OS18 The PCP for FMD (the pioneer …first risk management framework in animal health) • 1st PCP Guidelines, 2011 2nd PCP Guidelines, 2018 • Joint EuFMD/FAO/OIE
  • 16. OS18 PCP – stepwise along the road  Country Stages - facilitate progress monitoring  at national and regional level  Global scale -across Regional Roadmaps  and at every stage generates information for risk assessment
  • 17. OS18 PCP early days… This is how it felt working “”progressively”” with countries!!
  • 18. OS18 This is also how it felt at times - ! 2008-11
  • 19. OS18 2011: One Framework – from endemic to free without vaccination. In achievable Stages. Stage 3: option to apply for OIE endorsed National FMD Control programme OIE recognition and endorsement options Getting started: Policy , Strategy, Implementation Monitoring Evaluation
  • 21. OS18 West Eurasia Roadmap Outcome Criteria Questions COMPLETE THIS COLUMN Yes=1 , No=0 Not applicable=NA, Yellow = enter a number Outcome 1 All husbandry systems, the livestock marketing network and associated socio-economic drivers are well described for FMD susceptible species Animal movements are understood "Thoroughly described" means information is be available about numbers, origin and destination, reasons (drivers or motives) for the movement and any seasonal patterns 1.1 Are the movements of the key livestock species thoroughly described? 1.2 Are movements of cattle within the country thoroughly described? 1.3 Are movements of small ruminants within the country thoroughly described? 1.4 Are movements of swine within the country thoroughly described? 1.5 Are movements of cattle into the country thoroughly described? 1.6 Are movements of small ruminants into the country thoroughly described? 1.7 Are movements of swine into the country thoroughly described? 1.8 If there is transhumance or nomadic peoples, are the associated animal movement patterns thoroughly described? Stakeholders and incentives Stakeholders include farmers/producers PLUS all of the main players (people,organizations,companies) involved in breeding, transport of animals, milk/meat processing, feeding and marketing of animals. 1.9 Have key stakeholder categories involved in cattle production been identified? 1.10 Have key stakeholder categories involved in small ruminant production been identified? 1.1 Have key stakeholder categories involved in swine production been identified?
  • 22. OS18
  • 23. 23 Assessed Foreseen Countries 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 Afghanistan (absent in Bishkek) 0 1 1 1 1 1 1 1 1 1 2 2 2 2 3 3 3 4 Armenia 2 2 2 2 2 2 2* 2* 2 2 3 3 3 3 4 4 5 5 Azerbaijan 2 2 2 2 2 2 2* 2* 2 2 3 3 3 3 3 3 4 4 Georgia 2 1 1 1 1 1 2* 2 2 2 3 3 3 3 4 5 5 5 Iran 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 4 4 4 Kazakhstan (5 southern regions) 1 1 1 1 1 1 2* *** *** Kazakhstan (9 norther regions) 1 1 1 1 1 1 2* ** 5 5 5 5 5 5 5 5 5 5 Kyrgyzstan 1 0 0 0 1 1 2* 2* 2* 3 3 3 4 4 5 5 5 5 Pakistan 0 1 1 1 1 1 2* 2 2 2 2 3 3 3 3 3 4 4 Tajikistan 0 1 1 1 1 1 1 1 1 2 3 3 4 4 4 4 4 4 Turkey (Thrace) 5 5 5 5 5 5 5 5 5 5 Turkey(Anatolia/Marmara-Aegean) 2 3 3 4 4 4 4 4 5 5 Turkey (Remaining Anatolia) 1 2 2 2 2 2 2 2 2 2 2 2 2 3 3 4 4 4 Turkmenistan 0 0 0 0 1 1 1 1 1 2 2 2 2 3 3 4 4 5 Uzbekistan (absent in Bishkek) 0 1 1 1 1 1 1 1 1 2 3 3 3 4 4 5 5 5 Assessed by RAG Middle-East Iraq 1 1 1 1 1 2* 2* 2* Syria 1 1 1 1 1 2* 2* 2* 0 2 4 6 8 10 2012 2016 10 44 8 2 NO.COUNTRY stage 1 stage 2 stage 5 12-14 countries West Eurasia
  • 24. OS18 Eastern Africa Roadmap Vision for the Eastern Africa Roadmap for FMD control: • “An East African region in which FMD will be under control and approaching disease freedom (PCP-FMD Stage 3) in the majority of member states by 2020, with zonal or country freedom (PCP-FMD Stage 4) being reached in some parts of the sub region””
  • 25. OS18 SAARC Regional Roadmap meeting FAO-ICAR FMD conference
  • 26. OS18 Components of the FMD Global Strategy (FAO/OIE, 2012) 1 Improve global FMD control 2 Strengthening veterinary services 3 Improving the prevention and control of other major diseases of livestock
  • 27. OS18 Global Regional National GF-TADs FMD WG Developed the GS and coordinates its implementation Regional roadmap meetings for country assessment and capacity building Use of PCP-FMD guidelines as tool for implementation Strength Veterinary Services Support other TADs Global Network: • Network of FAO/OIE FMD Reference Lab • Global Expert Group Support regional laboratory and epidemiology networks + meetings Countries’ investment and control plans (FAO, OIE, EuFMD and donor support) Development of resource documents Regional proficiency test panels Performance of veterinary services (PVS) Promote regional collaboration and transparency, including cross border issues Promotion of success stories and in country support. FMD Global Strategy: Global, Regional and National application
  • 28. OS18 28 PHEFA SEAC FMD Pools 2-5 19 Roadmap meetings 3 2 6 4 5 7 1 Regional : addressing the 7 Ecosystems Regional Roadmap Meetings Convened Since 2012
  • 29. OS18 Progressive control in the endemic regions : FMD Global Map 2012 & 2017 The PCP is a framework for risk management - with 3 stages before entry into the OIE recognition system BUT: Rates of Progress differ between regions
  • 30. OS18 One Pathway ( No to be mistaken for One Road, One Belt ) http://www.gf-tads.org/fmd/progress-on-fmd-control-strategy/en/
  • 31. OS18 The Progressive movement • Completely new approach that has been taken up Global control of PPR, rabies, African trypanosomoses, … • PCP for brucellosis control in pipeline (end 2018) • Progressive “”management”” pathways • adaption to AMR and aquaculture health
  • 32. OS18 PCP toolkit : Self-Assessment of achievement Plan to study of epidemiological and soc- economics 1. Value chain analysis 2. FMD distribution & hypothesis 3. Socio-economic impact 4. Circulating strains 5. Strengthening Veterinary Services 6. Commitment to regional approach 7. Identification of "Hotspots" 8. Strategic FMD control plan Country's percentage achievement totally Minimum requirements for fulfiling Stage 1 Percentage achievement-required Checklist –Y/N -Not applicabl e To enter Stage 1 1.1 Is there a written plan in place to study the epidemiology and socioeconomic impact of FMD? 1 1.2 Does the plan include a study of the structure of livestock production throughout the country for all FMD susceptible species (cattle, sheep, goats)? 0 To have a comprehensive plan to study epidemiology and socio- economicsof FMD 1.3Does the plan include activities to estimate FMD prevalence? 1 1.4Does the plan include a timeline for activities?1 1.5Does the plan include a budget estimate for each activity? 1 1.6 Does the plan describe the organisational structure to carry out the study (defined roles and responsibilities, nominated persons) 1 1.7Have any of the activities described in the plan been initiated? 1 Stake holders include farmers/producers PLUS all of the main players (people,organizations,companies) involved in breeding, transport of animals, milk/meat processing, feeding and marketing of animals. There could be scoring for these questions: identified all, most, some, none Outcome 1 1.8Have key stakeholders involved in cattle production been identified? 0 1.9Have key stakeholders involved in small ruminant production been identified? 0 All husbandry systems, the livestock marketing network and associated socio-economic drivers are well described for FMD susceptible species 1.1Have key stakeholders involved in swine production been identified? 0 Information should be available about numbers, origin and destination, drivers or motives for the movement and any seasonal patterns there could be scoring based on how completely movements have been described (eg origin and destination known but not numbers, or for commercial farms only...) 1.1Are movements of animalswithin the country well understood for cattle? 0 1.1Are movements of animalswithin the country well understood for small ruminants? 0 1.1Are movements of animalswithin the country well understood for swine? 0 1.1Are movements of animalsinto the countrywell understood for cattle? 0 1.2Are movements of animalsinto the countrywell understood for small ruminants? 0 1.2Are movements of animalsinto the countrywell understood for swine? 0 1.2If there is transhumance or nomadic peoples, are their movement patterns understood?0 Outcome Criteria Questions Plan is comprehensive Quality indicators stakeholders movements
  • 33. OS18 PCP self-assessment online tool (2018, EuFMD/OIE/IZSLT) PCP tool team: Chris Bartels (EuFMD), Gregorio Torres (OIE), Giancarlo Ferrari (IZLST), Excel development: Tiziano Federici, Manuel Ajerbe Posada, Alessandra Alviti (EuFMD) Website: Andrea Vitelli (IZLST), Giancarlo Ferrari (IZLST)
  • 34. OS18 Progress on The PCP-FMD • Almost entirely funded by national programmes! • Assisted countries with internal processes of strategy development • International funding : Roadmaps (FAO and OIE co-fund) • Technical support: • Initially by FAO /EuFMD projects, later OIE projects (SEACFMD+..) • no PCP army or full time PCP officers ..a but “small company”” of PCP experts act as national support officers (2018, →Nick Lyons, EuFMD/TPI) • Suite of e-learning tools – open access (2016-) • PCP community - Network of PCP Practitioners (2016-18) (→Chris Bartels)
  • 35. OS18 How did we do on other OS08 recommendations? Vaccination: optimize by targeting to risks – introduced to national planning (PCP) Production systems need different vaccination programmes Chris Bartels & Melissa McLaws Iran – PCP Stage 1 project
  • 36. OS18 OS08 and vaccination Vaccination: optimize by targeting to risks – introduced to national planning (PCP) OIE/FAO Reference Centres → Annual Guidance Report per pool (from 2010)
  • 37. OS18 PCP early day push backs on vaccination • FMD eradication camp concept of “”control means total control”” (nothing is under control until everything is under control) • Compared to “”control begins at the epi-unit”” (farm, village..) • Thus: • Its useless to do anything unless you achieve 80%+ vaccination cover • Vs • “”Good immunity protects against disease at animal and epi-unit scale ..and can give immediate benefits””
  • 38. OS18 Erice 0S08 - new vaccines What did we do? • New vaccines: empty capsids “”should be pursued”” (→Session 7, Day 2) • GFRA members – carrying the torch in the darkness • Day 2 : • improving conventional vaccines • recombinant and attenuation (LL - Leaderless) vaccines • Improving master seed viruses
  • 39. OS18 OS08 and Measuring progress  Global Strategy needs … Global Progress Measurement:  Global Risk Report at least 2x per year (OIE/FAO)  Monthly Global Reports (EuFMD), Quarterly (WRL) and Annual (OIE/FAO FMD network) Х Epidemiological evidence - to measure “’real progress to reduce incidence”” Х Guidance was to focus on PCP process indicators NOT actual health (%NSP+..)  However as PCP was rolled out, sero-survey data 2008-12 allowed revised estimates of global FMD burdens and impacts (Knight-Jones & Rushton, 2013; Knight-Jones, McLaws & Rushton 2017)  Global strategy to place emphasis on monitoring efficacy of vaccination programmes  Post-Vaccination Monitoring (PVM) Guidelines, FAO/OIE  Associated e-learning courses and workshop training (EuFMD, WRL, IZS) (→Session 8) Х Thus : currently NO Annual Global Report combining virological , epidemiological and programmatic (PCP) progress in every region Х Separate virological and programmatic reports Х No systematic epi-report or vaccination reports GAP
  • 40. OS18 What did we do after OS08? Strategy for Regional and Global Control Ecosystems approach : 7 pools Regional workshops to develop longer term regional strategies (Roadmaps) BUT… Х FAO and OIE to address how increased investment/financing can be achieved with high buy-in from stakeholders Х Until 2017 : OIE/BMGF Initiative on PPP but focus on services - not financing Х Socio-economic issues preventing stakeholder investment must be addressed Х Identified in Stage 1- PCP but issues difficult to address in endemic regions
  • 41. OS18 Imagine if the people Controlled their own PCP Standing on their own feet Sharing responsibility You may say I’m a dreamer [I hope am not the only one]
  • 42. OS18 Lets be honest…What did we NOT do? • Address the fundamentals • Who pays? • Who takes responsibility? • You cannot vaccinate, without vaccine • Transform vaccine availability • Change enough minds on investment • Mainstream PCP into development agendas (World Bank projects etc)
  • 43. OS18 FMD control – who should pay for it? • Public good? • Vaccination to prevent a contagious disease • Defending borders against entry • Response and elimination of incursions • Private good? • FMD prevention as part of good production practice – the owner is the main economic beneficiary
  • 44. OS18 Issues for privatizing FMD vaccination – endemic countries • Policy : Can disease be controlled at herd level even if neighbours do not vaccinate • Supply issue: availability of quality vaccines LOW • Market development needs information ! • PPP – needs enabling environment for private uptake of vaccination • Experience/Risk tolerance of livestock owners No product on market Disease uncontrolled Living with losses Lack of market demand for vaccine Vaccine not produced for Africa
  • 45. OS18 Working better together? public, private and industry Public services •National FMD strategies •Prevention programmes •Enabling environment for health service delivery •Surveillance, Regulate and enforce •Register vaccines Private sector animal health •Herd level prevention and treatment services •Major option for service delivery (vaccination) •Maybe impeded by state actors from delivering services •Role of paravets Livestock industry •Animal wealth is in private hands •Potential for co-management of FMD issues with Government •Many players, may lack cohesive voice •Potential to establish management based high-health compartments with Often weak, unsupportive (endemic regions) Private sector often impeded from providing services on FMD lack access to quality vaccines or risk information for preventive plans Potential to drive change - if enabled to work with Government actors
  • 46. OS18 VACCINE Security is not equal Why should the FMD FREE COUNTRIES have the good VACCINE? CAN VACCINE BANKS BECOME PART OF THE GLOBAL SOLUTION? AESOP →Day 3 Break-out Session
  • 47. OS18 Assured Emergency Supply OPtions (AESOP) - may increase supply for FMD emergencies EuFMD Feasability study -2017/18 A new, potential additional option for access to vaccines in emergencies →Break-out: Day 3
  • 48. OS18 Keith’s Emphasis on the Vaccine Availability Notion
  • 49. OS18 Reaching out for a solution
  • 50. OS18 Why can’t livestock owners access FMD vaccines when they need them? MD
  • 51. OS18 Money is often NOT the problem. There are other barriers And FMD VACCINES →Session 2: Demand →Session 3 and 4 : supply and barriers
  • 52. OS18 Imagine… What would vaccine availability look like… And Google was to tell vaccine buyers whats available near you? If Amazon was to manage delivery? “ALEXA, find vaccines for tomorrow””
  • 53. OS18 Vaccine availability: why don’t we talk about it? • Its just too huge!!!! • so no one is talking about it • Why? • The needy are not in charge.. • PPP avoidance • Reluctance of international bodies to engage with private sector/pharma? • No equivalent of GAVI for animal health? • Or?
  • 54. OS18 Elephantine rumblings • Session 2: Demand: • Session 3: Supply: • Session 4: Breaking barriers • Session 5: Informatics for selection of vaccines • Session 6: Championing conventional vaccines • Session 7: Championing the new platforms • Session 8: Discussion on attenuated vaccines, and • 8B Directions in Vaccination Programme monitoring • Day 3 sign –up sessions • If you DON’T want to talk vaccines • Parallel sessions • Virology and immunopathogenesis • Modelling FMD transmission • Biosecurity and business continuity • Break-outs planned for Day 3 • Regional epidemiology • Diagnostic developments • Modelling regional spread (EuFMDis)
  • 55. OS18 Vaccine Security and the EuFMD workplan 2015-2019 Components 1.1 – Training for Member States 1.2 – Improved Contingency Planning 1.3 - Improved surveillance and management in Thrace 1.4 - improve emergency management capacity for FMD in the Balkan region 1.5 - FAR - Fund for Applied Research 1.6 - Emergency technical responses 1.7 - Proficiency test scheme 1.8 - Risk Analysis and Communication
  • 56. OS18 Training for Member States Training opportunities: Training is selected based on the EuFMD Training Menu and NTFP allocations; 388 Training Credits available to MSs The EuFMD e-Learning Virtual Learning Environment (VLE) now has over 7300 users, with 1600 new users added in the last six months. The online EuFMD Knowledge Bank is a searchable database of FMD related resources. And now contains over 450 resources and over 80 webinar recordings 1) Real Time Training 2) Online FMD Emergency Preparation Course: for multiple Member States in English 3) Online FMD Emergency Preparation Course: Tailored National Course Online course in national language, 4) Online FMD Emergency Preparation Course: subsequent national course 5) Workshop: “Managing a crisis” 6) Workshop: “FMD Simulation exercises” 7)Workshop:“Putting vaccination into practice” 8) Workshop: “FMD Wildlife surveillance” 9) Workshop: “Veterinary Ethics” 10) In-country support on FMD modelling 11) Laboratory Training Course 12) Regional event: Biorisk Training in collaboration with TPI
  • 57. OS18 Vaccine Security and European neighbourhood programme 2015-2019 Components 2.1 – South East Europe 2.2 - South East Mediterranean 2.3 - Support to REMESA 2.4 -Training development and coordination
  • 58. OS18 Pillar II: Reduced FMD risk to Members from European neighbourhood 1.Progression along PCP 2.Improve assessment of risk * 3.Implementation of risk based strategies (surveillance, vaccination, …) 4. Improved national capacity for FMD management (capacity building) Targets across the pillar
  • 59. OS18  Training on Safe Trade and FMD control RECENT COURSES DEVELOPED  Training on Containment zones  FMD surveillance and Post Vaccination Monitoring In progress
  • 60. OS18 Vaccine Security as a global issue > not directly addressed Components 3.1 - Improved system for monitoring and evaluation of progress of regional programmes on FMD control 3.2 – Support to Global Progress Monitoring of FMD Control programmes 3.3 - Laboratory support 3.4 – Global access to PCP-FMD training resources
  • 61. OS18 PCP Support Officers • DESK support to 25 countries • Guidance on PCP stage advancement and maintain momentum between roadmap meetings • Work with national PCP focal points and relevant regional FAO and OIE offices to provide guidance on PCP progression • System has been agreed by the FAO-OIE working group
  • 62. OS18 What I said at OS08, I believe more than ever…
  • 63. OS18 Progress yes −but the challenge remains to transform the daily reality of millions • Needs a massive upscaling in access to information, services – and vaccines • New focus on the First Mile/Last Mile is encouraging • Needs upscaling in vaccine supply • unmet demand must translate into sustained supply • MAJOR private sector investment and MAJOR public sector policy support needed • And Recognition that this is a common problem affecting multiple, preventable TADS • Vaccine security affects us all!
  • 64. OS18 Global issues – affecting prospects of progress Increasing Global security in the supply of effective FMD vaccines: can we really manage the risks and achieve progressive FMD control without it?”
  • 65. OS18 1. Global vaccine security : a useful concept? - means the assurance that sufficient and suitable vaccine is available at point of need 2. With assured supply, quality not availability would be the deciding factor 3. The scale of change needed demands a new approach - a global PPP for vaccine security 66 Regardless of where you live, global vaccine security matters (Keith Sumption, 2017) . Global vaccine insufficiency (insecurity) - affects us all? Thank you
  • 66. OS18 Acknowledgements > we could not have done this without all our progressive friends and colleagues • Nadia Rumich • Enrique Anton • Carsten Potszch, Giancarlo Ferrari *FAO, IZS, Juan Lubroth • Chris Bartels • Melissa McLaws • Nick Lyons • David Paton • Fabrizio Rosso • Jenny Maud • Cecile Carraz and the whole Operations Team • EuFMD Presidents Peter de Leeuw, Ulrich Herzog, Jean-Luc Angot • National PCP Focal points • Don King, WRL FMD, TPI and the OIE/FAO network • FAO (Samia Metwally, Julio Pinto, Peter de Leeuw) • OIE (Laure Weber-Vintzel, Gregorio Torres, Djahne Montabord) • EC DG SANTE (Alf Fuessel, B v Goethem) • Resource Partners for FAO and OIE PCP programmes • And hundreds more….