A successful experimentation program involves assessing opportunities, prioritizing experiments, and measuring program results. It assesses potential experiments by calculating expected value based on win rate, average lift, and revenue impact. Experiments are prioritized using a scoring model addressing business strategy, customer impact, opportunity size, and implementation effort. The program is measured using metrics like testing velocity, win rate, and revenue impact to track progress and identify improvement opportunities. Regular assessment allows the program to optimize operations and maximize overall expected value.