The lecture by Professor Abhik Roychoudhury at the MPI Distinguished Lecture 2019 discusses the challenges in program analysis, focusing on software error detection and automated program repair. It emphasizes the importance of symbolic execution and fuzzing techniques for detecting and repairing software defects, advocating for a systematic approach to program repair rather than reliance on random techniques. Furthermore, the talk explores the concept of specification inference and self-healing in programs when formal specifications are not available.