Significant figures are used to indicate the precision of measurement in a calculation or measurement. There are three main rules for determining which figures in a number are significant: 1) non-zero digits are always significant, 2) zeros between significant figures are significant, and 3) trailing zeros are only significant if a decimal is present. The number of significant figures impacts how numbers are rounded in calculations, with addition/subtraction rounding to the least decimal places and multiplication/division rounding to the least significant figures. Practice problems are provided to demonstrate applications of significant figures in calculations and measurements.