Precision medicine usage has tripled over the last 5 years, with 26% of US hospitals having procured a solution and 22% having gone live. General medical hospitals make up the majority of installations currently. Adoption is highest among multi-hospital nonprofit health systems and larger academic/specialty hospitals. Barriers to further growth include difficulties integrating genomic and other patient data into clinical systems and quantifying return on investment. The document examines trends in precision medicine adoption and provides insights on market leaders, barriers to growth, and signals that could indicate further expansion in the coming years.