36 Ischaemic heart disease, 85 
37 Thrombosis, 88 
38 Embolism and disseminated intravascular coagulation, 91 
39 Cardiac valvular disease, 94 
40 Myocardial and pericardial disease, 96 
Respiratory disease 
41 Pulmonary vascular disorders, 98 
42 Pneumonia, 100 
43 Bronchiectasis, 102 
44 Tuberculosis, 104 
45 Chronic obstructive pulmonary disease, 106 
46 Fibrosing alveolitis, 108 
47 Primary lung carcinoma, 110 
48 Other tumours of the lung and pleura, 112 
MATERIAL 
Gastrointestinal tract disease 
49 Malabsorption, 114 
50 Peptic ulceration and Helicobacter pylori, 116 
51 Oesophageal disease, 118 
52 Tumours of the stomach and small intestine, 120 
53 Mechanical disease of the gastrointestinal tract, 122 
54 Ulcerative colitis and Crohn’s disease, 124 
55 Adenomatous polyps, colorectal cancer and anal carcinoma, 126 
Hepatic and pancreaticobiliary disease 
56 Normal liver and the effects of liver damage, 128 
57 Jaundice, gallstones and carcinoma of the gallbladder, 130 
58 Alcoholic and non-alcoholic liver disease, 132 
59 Autoimmune hepatitis and cholangiopathies, 134 
60 Viral hepatitis, 136 
61 Cirrhosis, 139 
62 Acute and chronic pancreatitis, 142 
63 Tumours of the liver, biliary tree and pancreas, 144 
Genitourinary tract disease 
64 Congenital and inherited abnormalities of the kidney and 
urinary tract, 146 
65 The nephron and renal aspects of hypertension, 148 
66 Glomerulonephritis, 150 
67 Important types of glomerulonephritis, 152 
68 Tubulointerstitial diseases, 154 
69 Renal neoplasms, 156 
70 Bladder tumours, 158 
71 Testicular cancer, 160 
72 Prostatic disease, 162 
Gynaecological and obstetric disease 
73 Ovarian tumours, 164 
74 Benign uterine conditions, 166 
75 Uterine cancer, 168 
76 Cervical cancer, 170 
77 Obstetric pathology, 172 
78 Paediatric tumours, 174 
Nervous system disease 
79 Cerebrovascular accidents, 176 
80 Cerebrovascular accident syndromes, 178 
Contents 
Preface, 7 
Abbreviations, 8 
General pathology 
Introduction 
1 The normal human cell, 12 
2 Fluid dynamics, 14 
Tissue damage 
3 Tissue types and the effects of tissue damage, 16 
4 Cell death, 18 
5 Harmful agents in the environment, 20 
6 The effects of tobacco, alcohol and other drugs, 22 
7 Nutritional disorders, 24 
Inflammation and immunity 
8 The body’s natural defences, 26 
9 B cells and immunoglobulins, 28 
10 T cells, 30 
11 The major histocompatibility complex, 32 
12 The reticuloendothelial system, 34 
13 Acute inflammation, 36 
14 Chronic inflammation, 38 
15 Wound healing and repair, 40 
16 Infection and immunodeficiency, 42 
17 Shock, 44 
18 Tolerance and autoimmune disease, 46 
19 Hypersensitivity reactions, 48 
20 Overview of inflammation and immunity, 50 
Genetics 
21 Cell division, 52 
22 Genetic disease, 54 
Neoplasia 
23 Disordered cell growth, 56 
24 Basic concepts in neoplasia, 58 
25 Tumorigenesis and oncogenesis, 60 
26 Oncogenes and tumour suppressor genes, 62 
27 Common carcinoma histological subtypes, 64 
28 Tumour prognosis and treatment, 66 
Systems pathology 
Multisystems disease 
29 Sarcoidosis and syphilis, 70 
30 Wilson’s disease and haemochromatosis, 72 
31 Systemic vasculitis, 74 
Cardiovascular disease 
32 Normal blood vessels and types of aneurysm, 76 
33 Congenital heart disease, 78 
34 Systemic hypertension, 80 
35 Atherosclerosis, 82 
5 
COPYRIGHTED
6 Contents 
Musculoskeletal disease 
98 Muscle disorders, 212 
99 Arthritis, 214 
100 Miscellaneous non-neoplastic osteoarticular 
pathology, 216 
101 Bone tumours, 218 
Skin disease 
102 Inflammatory dermatoses, 220 
103 Benign skin tumours, 222 
104 Malignant skin tumours, 224 
Breast disease 
105 Benign breast disease, 226 
106 Breast carcinoma, 228 
Self-assessment 
Case studies and questions, 230 
Answers, 235 
Glossary, 240 
Reference ranges, 242 
Index, 243 
81 Raised intracranial pressure, 179 
82 Traumatic injury and intracranial haemorrhage, 180 
83 Central nervous system tumours, 182 
84 Infections of the nervous system, 184 
85 Movement disorders, 186 
86 Acquired disorders of myelination, 188 
87 Dementia, 190 
Endocrine disease 
88 Pituitary pathology, 192 
89 Non-neoplastic pathology of the thyroid, 194 
90 Thyroid neoplasms, 196 
91 Parathyroid gland pathology, 198 
92 Adrenal pathology, 200 
93 Diabetes mellitus, 202 
Head and neck pathology 
94 Head and neck pathology, 204 
Lymphoreticular disease 
95 Lymphoma, 206 
96 Myeloma, 208 
97 Assorted haematological conditions, 210

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1405136502 2

  • 1. 36 Ischaemic heart disease, 85 37 Thrombosis, 88 38 Embolism and disseminated intravascular coagulation, 91 39 Cardiac valvular disease, 94 40 Myocardial and pericardial disease, 96 Respiratory disease 41 Pulmonary vascular disorders, 98 42 Pneumonia, 100 43 Bronchiectasis, 102 44 Tuberculosis, 104 45 Chronic obstructive pulmonary disease, 106 46 Fibrosing alveolitis, 108 47 Primary lung carcinoma, 110 48 Other tumours of the lung and pleura, 112 MATERIAL Gastrointestinal tract disease 49 Malabsorption, 114 50 Peptic ulceration and Helicobacter pylori, 116 51 Oesophageal disease, 118 52 Tumours of the stomach and small intestine, 120 53 Mechanical disease of the gastrointestinal tract, 122 54 Ulcerative colitis and Crohn’s disease, 124 55 Adenomatous polyps, colorectal cancer and anal carcinoma, 126 Hepatic and pancreaticobiliary disease 56 Normal liver and the effects of liver damage, 128 57 Jaundice, gallstones and carcinoma of the gallbladder, 130 58 Alcoholic and non-alcoholic liver disease, 132 59 Autoimmune hepatitis and cholangiopathies, 134 60 Viral hepatitis, 136 61 Cirrhosis, 139 62 Acute and chronic pancreatitis, 142 63 Tumours of the liver, biliary tree and pancreas, 144 Genitourinary tract disease 64 Congenital and inherited abnormalities of the kidney and urinary tract, 146 65 The nephron and renal aspects of hypertension, 148 66 Glomerulonephritis, 150 67 Important types of glomerulonephritis, 152 68 Tubulointerstitial diseases, 154 69 Renal neoplasms, 156 70 Bladder tumours, 158 71 Testicular cancer, 160 72 Prostatic disease, 162 Gynaecological and obstetric disease 73 Ovarian tumours, 164 74 Benign uterine conditions, 166 75 Uterine cancer, 168 76 Cervical cancer, 170 77 Obstetric pathology, 172 78 Paediatric tumours, 174 Nervous system disease 79 Cerebrovascular accidents, 176 80 Cerebrovascular accident syndromes, 178 Contents Preface, 7 Abbreviations, 8 General pathology Introduction 1 The normal human cell, 12 2 Fluid dynamics, 14 Tissue damage 3 Tissue types and the effects of tissue damage, 16 4 Cell death, 18 5 Harmful agents in the environment, 20 6 The effects of tobacco, alcohol and other drugs, 22 7 Nutritional disorders, 24 Inflammation and immunity 8 The body’s natural defences, 26 9 B cells and immunoglobulins, 28 10 T cells, 30 11 The major histocompatibility complex, 32 12 The reticuloendothelial system, 34 13 Acute inflammation, 36 14 Chronic inflammation, 38 15 Wound healing and repair, 40 16 Infection and immunodeficiency, 42 17 Shock, 44 18 Tolerance and autoimmune disease, 46 19 Hypersensitivity reactions, 48 20 Overview of inflammation and immunity, 50 Genetics 21 Cell division, 52 22 Genetic disease, 54 Neoplasia 23 Disordered cell growth, 56 24 Basic concepts in neoplasia, 58 25 Tumorigenesis and oncogenesis, 60 26 Oncogenes and tumour suppressor genes, 62 27 Common carcinoma histological subtypes, 64 28 Tumour prognosis and treatment, 66 Systems pathology Multisystems disease 29 Sarcoidosis and syphilis, 70 30 Wilson’s disease and haemochromatosis, 72 31 Systemic vasculitis, 74 Cardiovascular disease 32 Normal blood vessels and types of aneurysm, 76 33 Congenital heart disease, 78 34 Systemic hypertension, 80 35 Atherosclerosis, 82 5 COPYRIGHTED
  • 2. 6 Contents Musculoskeletal disease 98 Muscle disorders, 212 99 Arthritis, 214 100 Miscellaneous non-neoplastic osteoarticular pathology, 216 101 Bone tumours, 218 Skin disease 102 Inflammatory dermatoses, 220 103 Benign skin tumours, 222 104 Malignant skin tumours, 224 Breast disease 105 Benign breast disease, 226 106 Breast carcinoma, 228 Self-assessment Case studies and questions, 230 Answers, 235 Glossary, 240 Reference ranges, 242 Index, 243 81 Raised intracranial pressure, 179 82 Traumatic injury and intracranial haemorrhage, 180 83 Central nervous system tumours, 182 84 Infections of the nervous system, 184 85 Movement disorders, 186 86 Acquired disorders of myelination, 188 87 Dementia, 190 Endocrine disease 88 Pituitary pathology, 192 89 Non-neoplastic pathology of the thyroid, 194 90 Thyroid neoplasms, 196 91 Parathyroid gland pathology, 198 92 Adrenal pathology, 200 93 Diabetes mellitus, 202 Head and neck pathology 94 Head and neck pathology, 204 Lymphoreticular disease 95 Lymphoma, 206 96 Myeloma, 208 97 Assorted haematological conditions, 210