Collateral crossing requires careful evaluation of angiograms to select the optimal collateral connection. Parameters like size, tortuosity, and insertion angle must be considered. Septal channels are initially approached with septal surfing to gently slide the wire through. If this fails, targeted crossing with tip injections may help reveal channel anatomy. Proper guidewire support and balloon anchoring can aid microcatheter advancement when issues arise. The goal is to safely cross collaterals and restore blood flow to the occluded vessel.