This study compared measures of body mass index (BMI), skinfold thickness, and waist circumference to assess disease risk in high school male athletes and non-athletes. 128 male students aged 15-18 from two high schools participated, with 78 identifying as athletes in sports like football, basketball, etc. and 50 non-athletes. BMI, skinfold thickness, and waist circumference were measured and used to categorize disease risk. Results found no significant differences between athletes and non-athletes. BMI was strongly associated with both percent body fat and waist circumference equally for athletes and non-athletes. While BMI can predict disease risk, combining BMI with other measures may provide a more accurate risk classification, especially for athletes.