The 2022 IPPS proposed rule includes changes to the inpatient quality reporting (IQR) program, introducing a mandatory hybrid hospital-wide all-cause mortality measure by 2023, along with the existing hybrid all-cause readmission measure. Hospitals are required to submit specific electronic clinical quality measures (ECQMs) starting from 2021, with some measures being publicly reported beginning in 2023. Additionally, the promoting interoperability program will see changes including a revised reporting period and new ECQMs, aligning with the IQR updates.