This document discusses the seismic design of foundations for the Rion Antirion Bridge in Greece. It describes the challenging soil and seismic conditions at the site, which required innovative foundation design. The foundations consist of large diameter caissons resting on top of reinforced natural ground, with steel tubular inclusions driven into the soil to increase its strength. Three of the four bridge piers use this reinforced foundation solution, while the fourth pier's caisson rests directly on a thick gravel layer without inclusions. The document outlines the design process and considerations, which aimed to ensure the foundations could adequately resist the large earthquake and ship impact loads expected at the seismically active site with poor soil conditions.