This document discusses the concept of constructing regional advantage from an evolutionary economic geography perspective. It defines comparative advantage, competitive advantage, and constructed advantage. Constructed advantage emphasizes that regional advantages are not spontaneous and can be constructed through partnerships between public and private actors. It is important to stimulate knowledge flows between related industries to support regional development. The concepts of related variety and unrelated variety are also discussed, with related variety referring to complementary knowledge between industries and unrelated variety providing more radical novelty. An example of constructing cross-border advantage between Galicia and northern Portugal is provided.