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The Muscular System




Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Learning Objectives
   List the 3 types of muscles and describe the characteristics of each.
   Describe the structure and function of tendons, aponeuroses, and
    ligaments.
   Differentiate between prime mover, antagonist, syngergist, and fixator
    muscles.
   List the locations and actions of the muscles of the head and neck,
    abdomen, thoracic limb, pelvic limb, and the muscles of respiration.
   Describe the microscopic anatomy of skeletal, smooth, and cardiac muscle
    cells.
   List the components of a neuromuscular junction and describe the function
    of each.
   Describe the events that occur in muscle cells during muscle contraction
    and relaxation.
   Differentiate between visceral smooth muscle and multiunit smooth muscle




              Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Muscle
   One of the four basic tissues of the body
   Made up of cells that can shorten or contract
   Three different types of muscle
    1. skeletal muscle
    2. cardiac muscle
    3.   smooth muscle




             Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Skeletal Muscle Gross Anatomy
   Tendons: fibrous connective tissue bands
   Aponeuroses: sheets of fibrous connective
    tissue
   Origin: the more stable of a muscle's
    attachment sites
   Insertion: site that undergoes most of the
    movement when a muscle contracts




         Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Muscle Actions
   Prime mover (agonist): a muscle or muscle
    group that directly produces a desired
    movement
   Antagonist: a muscle or muscle group that
    directly opposes the action of a prime
    mover




         Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Muscle Actions
   Synergist: a muscle that contracts at the
    same time as a prime mover and assists it
    in carrying out its action
   Fixator: muscles that stabilize joints to
    allow other movements to take place




         Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Muscle-Naming Conventions
   Action: e.g., flexor muscles; extensor
    muscles
   Shape: e.g., deltoid means “triangular
    shaped”
   Location: e.g., biceps brachii muscle is
    located in the brachial region
   Direction of fibers: e.g., rectus means
    “straight”


          Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Muscle-Naming Conventions
   Number of heads or divisions: -cep means
    “head”; biceps brachii muscle has two
    heads
   Attachment sites: e.g., origin of the
    sternocephalicus muscle is the sternum
    and insertion is the back of the head




         Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Cutaneous Muscles
   Thin, broad,
    superficial muscles
   Found in the fascia
    just beneath the
    skin
   Little or no
    attachment to
    bones
   Serve to twitch the
    skin
          Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Head and Neck Muscles
Functions
   Control facial expressions
   Enable mastication
   Move structures such as eyes and ears
   Support the head
   Allow the head and neck to flex, extend, and
    move laterally




           Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Head and Neck Muscles
   Masseter muscle - closes the jaw
   Splenius and trapezius muscles - extend
    the head and neck
   Brachiocephalicus muscle - extends the
    head and neck; also pulls the front leg
    forward
   Sternocephalicus muscle - flexes the head
    and neck


         Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Abdominal Muscles
Functions
 Support the abdominal organs

 Help flex the back

 Participate in various functions that involve

  straining
 Play a role in respiration




        Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Abdominal Muscles
   Arranged in layers
       External abdominal oblique muscle
       Internal abdominal oblique muscle
       Rectus abdominis muscle
       Transversus abdominis muscle
   Left and right parts of each muscle come
    together on the ventral midline at the linea
    alba



           Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Thoracic Limb Muscles
   Superficial muscles of the shoulder region
       Latissimus dorsi muscle - flexes the shoulder
       Pectoral muscles - one superficial and one
        deep; adduct the front leg
       Deltoid muscle - abducts and flexes the
        shoulder joint




            Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Thoracic Limb Muscles
   Brachial muscles
       Biceps brachii muscle - flexes the elbow joint
       Triceps brachii muscle - extends the elbow
        joint
   Carpal and digital muscles
       Extensor carpi radialis muscle - extends the
        carpus
       Deep digital flexor muscle - flexes the digit




            Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Pelvic Limb Muscles
   Gluteal muscles - extensor muscles of the
    hip
   “Hamstring" muscle group - extend the hip
    joint; main flexors of the stifle joint
       Biceps femoris muscle
       Semimembranosus muscle
       Semitendinosus muscle




           Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Pelvic Limb Muscles
   Quadriceps femoris muscle - main
    extensor muscle of the stifle joint
   Gastrocnemius muscle - extensor muscle
    of the hock




         Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Muscles of respiration
Function
 Increase and decrease the size of the

  thoracic cavity
     Inspiratory muscles
        • Diaphragm
        • External intercostal muscles
     Expiratory muscles
        • Internal intercostal muscles
        • Abdominal muscles

          Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Skeletal Muscle Cells
   Very large
   Multinucleate
   Numerous myofibrils
    composed of actin
    and myosin
   Network of sarcoplasmic
    reticulum
   T tubules

         Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Skeletal Muscle Cells
   A bands: thick
    myosin filaments
   I bands: thin
    actin filaments
       Dark line in the center
        of the I band is the Z line
       Disk that is the attachment
        site for the actin filaments



            Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Skeletal Muscle Cells
   Sarcomere - basic
    contracting unit of
    skeletal muscle
   Area from one Z
    line to the next Z line
   Each myofibril is
    made up of many
    sarcomeres lined
    up end to end.
          Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Neuromuscular Junction
   Nerves and muscles
    separated by the
    synaptic space
   Synaptic vesicles -
    sacs at the end of a
    nerve fiber; contain
    acetylcholine
       Acetylcholinesterase -
        enzyme in the synaptic
        space that removes
        acetylcholine


            Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Motor Unit
   One nerve fiber and all the muscle fibers it
    innervates
   Muscles that make small, delicate
    movements have only a few muscle fibers
    per nerve fiber in each motor unit
   Large, powerful muscles may have a
    hundred or more muscle fibers per motor
    unit



          Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Connective Tissue Layers
   Hold components of the muscle together
   Contain the blood vessels and nerve fibers
    that supply the muscle fibers
   Continuous with tendons or aponeuroses
    that connect muscle to bones or other
    muscles




         Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Connective Tissue Layers
   Endomysium - composed of fine, reticular
    fibers; surrounds each muscle fiber
   Fascicles - groups of skeletal muscle
    fibers
   Perimysium - composed of reticular fibers
    and thick collagen fibers; surrounds
    fascicles
   Epimysium - fibrous layer composed of
    tough collagen fibers; surrounds groups of
    muscle fascicles
          Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Initiation of Muscle Contraction &
                 Relaxation
   Nerve impulse reaches the end bulb of the
    motor nerve fiber
   Acetylcholine is released into the synaptic
    space
   Acetylcholine molecules bind to receptors
    on the surface of the sarcolemma
   Impulse travels along the sarcolemma and
    through the T tubules to the interior of the
    cell

          Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Initiation of Muscle Contraction &
                 Relaxation
   Impulse reaches the sarcoplasmic
    reticulum
   Calcium ions (Ca++) are released into the
    sarcoplasm
   Ca++ diffuses into the myofibrils and starts
    the contraction process




          Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Initiation of Muscle Contraction &
                 Relaxation
   Sarcoplasmic reticulum begins pumping
    Ca++ back in again
   Ca++ is pulled out of the myofibrils
   Contraction stops, muscle returns to its
    original length




          Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Mechanics of Muscle Contraction
   Relaxed muscle fibers have actin and
    myosin filaments that slightly overlap
   When stimulated to contract, crossbridges
    on myosin filaments slide back and forth




         Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Mechanics of Muscle Contraction
   Actin filaments on both sides are pulled
    toward the center of the myosin filaments.
   This shortens the sarcomere.
   Shortening of all the end-to-end
    sarcomeres in a muscle fiber results in a
    muscle contraction.




          Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Characteristics of Muscle
                Contraction
All-or-nothing principle
   When stimulated, an individual muscle fiber either
    contracts completely or not at all.
   Nervous system controls the number of muscle
    fibers it stimulates for a particular movement
       Small, fine movements require only a few muscle fibers
        to contract.
       Larger, more powerful movements require contraction of
        many muscle fibers.




            Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Muscle Contraction
Three phases:
 1. Latent phase - time between nerve
 stimulus and beginning of contraction (about
 10 ms)
 2. Contracting phase - lasts about 40 ms
 3. Relaxation phase - lasts about 50 ms




        Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Muscle Contraction
   Maximum contraction efficiency occurs if
    nerve impulses arrive about 0.1 second
    apart.
   Results in a series of complete muscle
    fiber twitches
   Careful timing of the nerve impulses to
    motor units of the muscle is needed to
    make muscle contract smoothly.



         Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Chemistry of Muscle Contraction
   ATP provides energy to allow the sliding of
    the actin and myosin filaments
   Creatine phosphate converts ADP back to
    ATP
   Glucose and Oxygen - help produce ATP
    & CP
       Glucose stored in muscle as glycogen
       Oxygen stored as myoglobin



           Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Chemistry of Muscle Contraction
   Anaerobic metabolism - used if oxygen
    need exceeds oxygen supply
       Results in lactic acid formation
       Lactic acid accumulation causes discomfort




           Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Heat Production
   Muscle activity generates heat
   Panting or sweating - mechanisms to
    eliminate excess heat
   Shivering - spasmodic muscle contractions
    that increase heat production




         Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Cardiac Muscle
   Small cells with single nucleus
   Intercalated disks:
    attachments between cardiac
    muscle cells
       Allow transmission of impulses
        from cell to cell for coordinated
        contraction of large groups of cells




            Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Physiology of Cardiac Muscle
   Cardiac cells contract without any external
    stimulation
   Groups of cardiac muscle cells contract at
    the rate of the most rapid cell in the group
   Contractions are rapid and wavelike




          Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Physiology of Cardiac Muscle
Cardiac Conduction System
 Sinoatrial (SA) node

       Generates the impulse that starts each
        heartbeat
       Located in the wall of the right atrium
   Impulse follows a controlled path through
    the conduction system of the heart
   Structures in the system transmit, delay,
    and redirect

            Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Nerve Supply
   Heart is innervated by nerves from both
    the sympathetic and parasympathetic
    systems
   Sympathetic fibers stimulate the heart to
    beat harder and faster as part of the "fight
    or flight response”
   Parasympathetic fibers inhibit cardiac
    function, causing the heart to beat more
    slowly and with less force

          Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Smooth Muscle Gross Anatomy
Two main forms
   Visceral smooth muscle
       Large sheets of cells in the walls of some
        hollow organs
   Multiunit smooth muscle
       Small, discrete groups of cells




            Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Smooth Muscle Cells
   Small, spindle-shaped;
    single nucleus
   Actin and myosin
    filaments arranged
    as small contractile
    units that crisscross
    the cell
       Attached at both ends to
        "dense bodies" that correspond
        to the Z lines of skeletal muscle

             Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Visceral Muscle
   Found in the walls of many internal organs
    (e.g., stomach, intestines, uterus, urinary
    bladder)
   Contracts in large, rhythmic waves
   Contracts without external stimulation
       Reacts to stretching by contracting more
        strongly
       Innervated by nerves from both the
        sympathetic and parasympathetic systems
       Sympathetic stimulation decreases activity;
        parasympathetic stimulation increases activity
            Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
Multi-Unit Smooth Muscle
   Individual smooth muscle cells or small
    groups of cells
   Found where small, delicate contractions
    are needed (e.g., iris, walls of small blood
    vessels)
   Contraction requires autonomic nervous
    system impulse




          Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.

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7. The Muscular System

  • 1. The Muscular System Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 2. Learning Objectives  List the 3 types of muscles and describe the characteristics of each.  Describe the structure and function of tendons, aponeuroses, and ligaments.  Differentiate between prime mover, antagonist, syngergist, and fixator muscles.  List the locations and actions of the muscles of the head and neck, abdomen, thoracic limb, pelvic limb, and the muscles of respiration.  Describe the microscopic anatomy of skeletal, smooth, and cardiac muscle cells.  List the components of a neuromuscular junction and describe the function of each.  Describe the events that occur in muscle cells during muscle contraction and relaxation.  Differentiate between visceral smooth muscle and multiunit smooth muscle Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 3. Muscle  One of the four basic tissues of the body  Made up of cells that can shorten or contract  Three different types of muscle 1. skeletal muscle 2. cardiac muscle 3. smooth muscle Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 4. Skeletal Muscle Gross Anatomy  Tendons: fibrous connective tissue bands  Aponeuroses: sheets of fibrous connective tissue  Origin: the more stable of a muscle's attachment sites  Insertion: site that undergoes most of the movement when a muscle contracts Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 5. Muscle Actions  Prime mover (agonist): a muscle or muscle group that directly produces a desired movement  Antagonist: a muscle or muscle group that directly opposes the action of a prime mover Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 6. Muscle Actions  Synergist: a muscle that contracts at the same time as a prime mover and assists it in carrying out its action  Fixator: muscles that stabilize joints to allow other movements to take place Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 7. Muscle-Naming Conventions  Action: e.g., flexor muscles; extensor muscles  Shape: e.g., deltoid means “triangular shaped”  Location: e.g., biceps brachii muscle is located in the brachial region  Direction of fibers: e.g., rectus means “straight” Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 8. Muscle-Naming Conventions  Number of heads or divisions: -cep means “head”; biceps brachii muscle has two heads  Attachment sites: e.g., origin of the sternocephalicus muscle is the sternum and insertion is the back of the head Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 9. Cutaneous Muscles  Thin, broad, superficial muscles  Found in the fascia just beneath the skin  Little or no attachment to bones  Serve to twitch the skin Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 10. Head and Neck Muscles Functions  Control facial expressions  Enable mastication  Move structures such as eyes and ears  Support the head  Allow the head and neck to flex, extend, and move laterally Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 11. Head and Neck Muscles  Masseter muscle - closes the jaw  Splenius and trapezius muscles - extend the head and neck  Brachiocephalicus muscle - extends the head and neck; also pulls the front leg forward  Sternocephalicus muscle - flexes the head and neck Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 12. Abdominal Muscles Functions  Support the abdominal organs  Help flex the back  Participate in various functions that involve straining  Play a role in respiration Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 13. Abdominal Muscles  Arranged in layers  External abdominal oblique muscle  Internal abdominal oblique muscle  Rectus abdominis muscle  Transversus abdominis muscle  Left and right parts of each muscle come together on the ventral midline at the linea alba Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 14. Thoracic Limb Muscles  Superficial muscles of the shoulder region  Latissimus dorsi muscle - flexes the shoulder  Pectoral muscles - one superficial and one deep; adduct the front leg  Deltoid muscle - abducts and flexes the shoulder joint Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 15. Thoracic Limb Muscles  Brachial muscles  Biceps brachii muscle - flexes the elbow joint  Triceps brachii muscle - extends the elbow joint  Carpal and digital muscles  Extensor carpi radialis muscle - extends the carpus  Deep digital flexor muscle - flexes the digit Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 16. Pelvic Limb Muscles  Gluteal muscles - extensor muscles of the hip  “Hamstring" muscle group - extend the hip joint; main flexors of the stifle joint  Biceps femoris muscle  Semimembranosus muscle  Semitendinosus muscle Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 17. Pelvic Limb Muscles  Quadriceps femoris muscle - main extensor muscle of the stifle joint  Gastrocnemius muscle - extensor muscle of the hock Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 18. Muscles of respiration Function  Increase and decrease the size of the thoracic cavity  Inspiratory muscles • Diaphragm • External intercostal muscles  Expiratory muscles • Internal intercostal muscles • Abdominal muscles Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 19. Skeletal Muscle Cells  Very large  Multinucleate  Numerous myofibrils composed of actin and myosin  Network of sarcoplasmic reticulum  T tubules Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 20. Skeletal Muscle Cells  A bands: thick myosin filaments  I bands: thin actin filaments  Dark line in the center of the I band is the Z line  Disk that is the attachment site for the actin filaments Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 21. Skeletal Muscle Cells  Sarcomere - basic contracting unit of skeletal muscle  Area from one Z line to the next Z line  Each myofibril is made up of many sarcomeres lined up end to end. Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 22. Neuromuscular Junction  Nerves and muscles separated by the synaptic space  Synaptic vesicles - sacs at the end of a nerve fiber; contain acetylcholine  Acetylcholinesterase - enzyme in the synaptic space that removes acetylcholine Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 23. Motor Unit  One nerve fiber and all the muscle fibers it innervates  Muscles that make small, delicate movements have only a few muscle fibers per nerve fiber in each motor unit  Large, powerful muscles may have a hundred or more muscle fibers per motor unit Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 24. Connective Tissue Layers  Hold components of the muscle together  Contain the blood vessels and nerve fibers that supply the muscle fibers  Continuous with tendons or aponeuroses that connect muscle to bones or other muscles Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 25. Connective Tissue Layers  Endomysium - composed of fine, reticular fibers; surrounds each muscle fiber  Fascicles - groups of skeletal muscle fibers  Perimysium - composed of reticular fibers and thick collagen fibers; surrounds fascicles  Epimysium - fibrous layer composed of tough collagen fibers; surrounds groups of muscle fascicles Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 26. Initiation of Muscle Contraction & Relaxation  Nerve impulse reaches the end bulb of the motor nerve fiber  Acetylcholine is released into the synaptic space  Acetylcholine molecules bind to receptors on the surface of the sarcolemma  Impulse travels along the sarcolemma and through the T tubules to the interior of the cell Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 27. Initiation of Muscle Contraction & Relaxation  Impulse reaches the sarcoplasmic reticulum  Calcium ions (Ca++) are released into the sarcoplasm  Ca++ diffuses into the myofibrils and starts the contraction process Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 28. Initiation of Muscle Contraction & Relaxation  Sarcoplasmic reticulum begins pumping Ca++ back in again  Ca++ is pulled out of the myofibrils  Contraction stops, muscle returns to its original length Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 29. Mechanics of Muscle Contraction  Relaxed muscle fibers have actin and myosin filaments that slightly overlap  When stimulated to contract, crossbridges on myosin filaments slide back and forth Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 30. Mechanics of Muscle Contraction  Actin filaments on both sides are pulled toward the center of the myosin filaments.  This shortens the sarcomere.  Shortening of all the end-to-end sarcomeres in a muscle fiber results in a muscle contraction. Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 31. Characteristics of Muscle Contraction All-or-nothing principle  When stimulated, an individual muscle fiber either contracts completely or not at all.  Nervous system controls the number of muscle fibers it stimulates for a particular movement  Small, fine movements require only a few muscle fibers to contract.  Larger, more powerful movements require contraction of many muscle fibers. Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 32. Muscle Contraction Three phases: 1. Latent phase - time between nerve stimulus and beginning of contraction (about 10 ms) 2. Contracting phase - lasts about 40 ms 3. Relaxation phase - lasts about 50 ms Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 33. Muscle Contraction  Maximum contraction efficiency occurs if nerve impulses arrive about 0.1 second apart.  Results in a series of complete muscle fiber twitches  Careful timing of the nerve impulses to motor units of the muscle is needed to make muscle contract smoothly. Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 34. Chemistry of Muscle Contraction  ATP provides energy to allow the sliding of the actin and myosin filaments  Creatine phosphate converts ADP back to ATP  Glucose and Oxygen - help produce ATP & CP  Glucose stored in muscle as glycogen  Oxygen stored as myoglobin Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 35. Chemistry of Muscle Contraction  Anaerobic metabolism - used if oxygen need exceeds oxygen supply  Results in lactic acid formation  Lactic acid accumulation causes discomfort Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 36. Heat Production  Muscle activity generates heat  Panting or sweating - mechanisms to eliminate excess heat  Shivering - spasmodic muscle contractions that increase heat production Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 37. Cardiac Muscle  Small cells with single nucleus  Intercalated disks: attachments between cardiac muscle cells  Allow transmission of impulses from cell to cell for coordinated contraction of large groups of cells Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 38. Physiology of Cardiac Muscle  Cardiac cells contract without any external stimulation  Groups of cardiac muscle cells contract at the rate of the most rapid cell in the group  Contractions are rapid and wavelike Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 39. Physiology of Cardiac Muscle Cardiac Conduction System  Sinoatrial (SA) node  Generates the impulse that starts each heartbeat  Located in the wall of the right atrium  Impulse follows a controlled path through the conduction system of the heart  Structures in the system transmit, delay, and redirect Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 40. Nerve Supply  Heart is innervated by nerves from both the sympathetic and parasympathetic systems  Sympathetic fibers stimulate the heart to beat harder and faster as part of the "fight or flight response”  Parasympathetic fibers inhibit cardiac function, causing the heart to beat more slowly and with less force Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 41. Smooth Muscle Gross Anatomy Two main forms  Visceral smooth muscle  Large sheets of cells in the walls of some hollow organs  Multiunit smooth muscle  Small, discrete groups of cells Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 42. Smooth Muscle Cells  Small, spindle-shaped; single nucleus  Actin and myosin filaments arranged as small contractile units that crisscross the cell  Attached at both ends to "dense bodies" that correspond to the Z lines of skeletal muscle Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 43. Visceral Muscle  Found in the walls of many internal organs (e.g., stomach, intestines, uterus, urinary bladder)  Contracts in large, rhythmic waves  Contracts without external stimulation  Reacts to stretching by contracting more strongly  Innervated by nerves from both the sympathetic and parasympathetic systems  Sympathetic stimulation decreases activity; parasympathetic stimulation increases activity Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.
  • 44. Multi-Unit Smooth Muscle  Individual smooth muscle cells or small groups of cells  Found where small, delicate contractions are needed (e.g., iris, walls of small blood vessels)  Contraction requires autonomic nervous system impulse Mosby items and derived items © 2008 by Mosby, Inc., an affiliate of Elsevier Inc.