Three mice will be in the barn in 2 years according to the following:
If the number of mice quadruples every 4 months, starting with 2 mice, there will be 8 mice after 4 months. After 2 years (8 periods of 4 months), the number of mice will triple each period for a total of 3 * 8 = 24 mice. However, since there are only 2 mice to start, there will be 3 mice after 2 years.