A comprehensive study on disease risk predictions in machine learning

International Journal of Electrical and Computer Engineering (IJECE)
Vol. 10, No. 4, August 2020, pp. 4217~4225
ISSN: 2088-8708, DOI: 10.11591/ijece.v10i4.pp4217-4225  4217
Journal homepage: http://ijece.iaescore.com/index.php/IJECE
A comprehensive study on disease risk predictions
in machine learning
G. Saranya, A. Pravin
Department of Computer Science and Engineering, Sathyabama Institute of Science and Technology, India
Article Info ABSTRACT
Article history:
Received Oct 4, 2019
Revised Feb 22, 2020
Accepted Feb 29, 2020
Over recent years, multiple disease risk prediction models have been
developed. These models use various patient characteristics to estimate
the probability of outcomes over a certain period of time and hold
the potential to improve decision making and individualize care. Discovering
hidden patterns and interactions from medical databases with growing
evaluation of the disease prediction model has become crucial. It needs many
trials in traditional clinical findings that could complicate disease prediction.
A Comprehensive study on different strategies used to predict disease is
conferred in this paper. Applying these techniques to healthcare data, has
improvement of risk prediction models to find out the patients who would get
benefit from disease management programs to reduce hospital readmission
and healthcare cost, but the results of these endeavors have been shifted.
Keywords:
Breast cancer
Disease prediction
Heart disease
Machine learning
Prediction models Copyright © 2020 Institute of Advanced Engineering and Science.
All rights reserved.
Corresponding Author:
G. Saranya,
Research Scholar, Department of Computer Science and Engineering,
Sathyabama Institute of Science and Technology,
Jeppiaar Nagar, Rajiv Gandhi Salai, Chennai-600 119, Tamilnadu, India.
Email: saranyag3@srmist.edu.in
1. INTRODUCTION
Machine learning is one of the most prevalent methods used in multiple computer engineering areas
and has been commonly used in the processing of natural language, picture processing, pattern recognition,
cyber security, and multiple areas. One of the most dynamic researches of machine learning is healthcare
industry [1]. As healthcare firms are trying to collect records of patients, estimates show that there are about
1 trillion bytes of information, which is increasing every day. These data need to be properly extracted to
obtain precious information [2].
Sometimes patients fail to define their medical problems correctly and the results of laboratory
research can lead to some degree of mistake. Specialists find it difficult to make decisions about the illnesses
because they may not have skills in all areas. To address this issue, it is necessary to develop a disease
prediction system that combines medical knowledge with an integrated system to produce the biggest results
and can help society [3].
Several earlier investigations tried to use patient laboratory tests [4-6] and drugs [7] to predict
the occurrence of disease. Such prototypes were also used to define unknown risk factors, often while
enhancing sensitivity and specificity of detection simultaneously. Recent studies have been effective in
predicting disease through multiple methods, including supporting vector machines [8-10], logistical
regression [11], random forests [3, 12], neural networks [4, 13], and time series modeling techniques [14].
In summary, the paper focuses on various disease prediction models of machine learning. The paper
is structured in the following way. Section 2 explains the basic concept of machine learning, prediction
models and types of prediction models. Section 3 explains the survey of disease prediction models. Section 4
explains the comparative study of heart diseases. Section 5 summarizes a comparative study of breast cancer.
Section 6 gives the conclusion and future enhancement.

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2. INTRODUCTION TO MACHINE LEARNING
Machine learning (ML) is an artificial intelligence (AI) branch that helps analyze the data structure
and fit the information into models correctly. It is one of the computer science fields, and differs from other
computing technology by the way of training the computers based on data inputs and it uses statistical
analysis to get the proper output. For this reason, ML is used in automated decision-making models like
Facial recognition, Recommendation engines, OCR and Self driving car applications.
Machine learning methods are categorized into three classifications according to the training
processes used. The categories are supervised machine learning, unsupervised machine learning and
reinforcement learning. In supervised learning, the data samples with category labels are used in training.
Classification and regression models are examples of supervised learning. The algorithms used in this
approach are decision tree, naïve bayes etc. In unsupervised learning, the data samples are directly used in
training without category label. Clustering techniques and encoders are the basic examples of unsupervised
approach. Reinforcement learning is a mixture of prior two approaches. It uses agent that finds the correct
action to achieve the overall goal of the application [15].
3. PREDICTION MODELS
A prediction model is characterized as a model that provides a way to evaluate the individual danger
of a patient for the outcome of a disease. The question of when, what and how to use these models arises with
the growth of such prediction models. These models can be taught over time, providing the demands of
the company, to react to new information or views.
Two types of prediction models exist. They are models of classification predicting class outcomes,
and models of regression predicting the relationship between a response variable Y and a predictor
variable X. Various basic and advanced algorithm, listed in Figure 1, Figure 2 conducts data analysis and
statistical analysis and determine information trends and patterns. While machine learning and prediction
analysis can provide an opportunity for any implementation, the haphazard implementation of these options
will drastically impede their ability to provide insight into the demands of the organization without
considering how they fit into everyday operations. Organizations need to guarantee that they have
the architecture in place to support these alternatives, as well as high-quality information to feed them and
assist them learn, to make the most of prediction analytics and machine learning [16].
Figure 1. Basic prediction techniques Figure 2. Advanced prediction techniques
4. EXISTING TECHNIQUES FOR DISEASE PREDICTION
Mingyu Pak, Miyoung Shin [17], explored few environmental variables linked to type-2 diabetes
disease and selected some variables to develop an analytical prototype of prediction of disease. For the choice
of important variables, they first pre-processed all external environmental factors into numerical data and
then estimated the maximum/minimum probability ratios of all the sorted exogenous variables.
The top-n positioned variables were then chosen as input variables for the forecast model depending on
ansan/ansung cohort 2 data collected from the Korean National Institute of Health (KNIH), the disease risk
factor prediction model was created using SVM. Their prediction model showed the output of 65.97 percent
precision and showed very identical performance only with genetic factors with particular environmental
variables to the model [17].

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A comprehensive study on disease risk predictions in machine learning (G. Saranya)
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The research shown in [18] focuses on disease forecasting from medical information supplied by
New York's Presbyterian Hospital. Since these are medical information, predicting computerized predictions
is generally unique and simpler than forecasting user text inputs. Nicolae Dragu et al discussed-on forecast of
serious contagious diseases from web material sources, which is also a specific origin where open clinical
terms are used [19]. Many attempts have been made to forecast selective diseases [20, 21]. For instance,
the authors in [20] deal with the prediction by mining content of coronary heart disease. There are also
an important amount of study works on medicinal services debates that have been carried out. Lav petrov
used NLP to evaluate and break down user remarks to predict disease and concentrate uncommon responses
to drugs [22].
Ryan McDonald et al, use a terminology-laden interface (i.e. clients need to explore a long list of
hints). It's an awkward job from the user's view, and the operation is also tedious. Also, if the customers do
not find a certain indication, they are forced to prevent that symptom that is not in any manner desired [23].
Client's directed text input [24, 25]. They rely on negligible symptom-disease relationship system [26, 27] in
any situation and use complete content database. These frameworks begin to search for accurate term match
at the input of the client from each input line in the database. For example, if a client with symptoms
equivalent is not specified in the database, then we cannot match the information correctly. If the user input
should contain a greater number of semi-technical terms than anticipated, it will degrade its performance.
The system used is especially strong and restricted to particular data types.
Xiaoyan Wang et al, proposed an automated system for disease prediction that based on the client's
driven feedback. Their structure requires input from the client such as the names of symptoms and certain
significant parameters and provides a list of likely illnesses (maximum infections are more likely to occur).
The accuracy of the automated disease prediction scheme (ADPS) evaluated the solution of the current
scheme with a standard 14.35 percent greater accuracy in examination [28]. S Manimekala et al, suggested
that the Automatic Disease Prediction technique determine the most probable disease based on the feedback
of the patient that facilitates early detection. The model uses data mining algorithm apriori-frequent pattern
(A-FP) to identify illnesses through health data mining focused on the signs of input. This method is used for
finding medical datasets from which to create association rules. The goal is to identify from the health dataset
relevant and frequent illnesses [29].
Cristinel Ababei et al, discussed the overall context of computer frameworks on multicore processor
systems, they provided a discussion on the most common prediction and classification methods.
They introduced some prediction systems from simple to more complicated, while highlighting one frequent
basic theme: each of these systems misuses the prior history of the variable of interest [30]. Ankita Dewan et
al, in conjunction with the back-propagation method, they suggested a successful genetic algorithm for
predicting heart disease and created a model that could identify and extract unknown data (patterns and
relationships) linked to coronary heart disease from archived database records of heart disease [31]. Table 1
shows the different methods and their advantages and disadvantages. The merits and demerits are specified in
terms of efficiency, prediction accuracy and how easily a model could be implemented.
Table 1. Merits and demerits of prediction techniques
Methods Pros Cons
KNN Simple, high accuracy Local information structure sensitivity. Calculated slowly.
Linear Regression Accuracy of good prediction
Training needs. When fresh information arrive,
coefficients may need to be updated constantly.
SVM Practically efficient, very popular
The size of the training information can improve the
number of bias functions. Selection of parameters
depends on information.
Bayes classifier high accuracy, efficient Training needs
LDA Fast, Implementation is comparatively simple Training needs
4.1. Description of existing techniques for heart disease prediction
P. K. Anooj [32], suggested a decision-making scheme based on fuzzy rules to assess the level of
risk of heart disease. He first pre-processed the information for missing values in his method. He then
performed fuzzy sets generation and created a fuzzy decision-making system. The technique selects
the required attribute based on the number of events in the database to create weighted fuzzy laws.
These weighted fuzzy rules are then used to create a decision-based scheme of assistance. He tested his
suggested scheme on three distinct dataset kinds that are collected from V.A. Cleveland dataset. Medical
centre with 303 cases of training data for 202 documents and test information for 101 documents. P. K.
Anooj contrasted his model with models based on neural networks and obtained the greatest precision [32].

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Tsipouras M.G., et al. [33] suggested an automated system based on fuzzy modeling and
information mining to predict heart disease. His model includes measures such as inferring information
decision tree, extracting guidelines, formulating crisp model, transforming crisp model into fuzzy model, and
optimizing it. The information gathered from Invasive Cardiology, University Department, Ioannina
Hospital. The technique provides 80% precision in awareness and 65% precision in specificity [33].
Chaitrali S. Dangare et al. [34], used heart disease prediction data mining method. He first
pre-processed the missing information using the mean mode technique and used the perceptron multi-layer
model to map the information. To analyse the database of heart disease, Naive bays, neural networks and
decision tree were used. He gathered 303 documents from the repository of Cleveland heart disease and used
it as a training set and gathered 270 documents as test information from the repository of Stat log Heart
Disease. The information set consists of attribute, input and key predictable. His model provides 100%
accuracy for neural networks, Decision tree with 99.62 and Naïve bayes with 90.74% precision [34].
Mai Shouman et al. [35], by incorporating decision tree and k-means clustering, suggested
a technique for diagnosing patients with heart disease. For k-means, the method utilizes centroid selection
technique and decision tree is used to determine the clusters. Thirteen distinct characteristics are gathered
from the Cleveland Clinic Foundation Heart Disease. Compared to the current decision tree, the integrated
model of k-means and decision tree obtained greater outcomes of 83.9% [35].
S. Pal et al [36], suggested using information mining to predict heart disease. He surveyed 3 distinct
classifiers such as CART, ID3 and tree of Decision. The information set from the Cleveland Clinic
Foundation shows that 83.49 percent of the classification and regression tree (CART) precision was much
better than the decision tree and ID3 (Iterative Dichotomized 3) [36]. H. A. Huijer et al. [37], designed
a decision support service to find unrest transition through decision trust measure, trust-based SVM and
trust-based multilevel SVM to discover agitation transition. 240 Samples are gathered via human body
sensors. The patient experiences distinctive tension inventory of state-quality scale (T-STAI), used to
calculate uncomfortable adults. The technique provides 91.4 percent precision when compared to traditional
vector supporting machine with 90.9 percent precision [37].
Latha Parthiban et al. [38], outlined a prediction technique for smart heart disease prediction.
The method is executed using coactive neuro fuzzy inference system, neural network, and genetic algorithm.
The dataset is gathered from UCI and the prototype is simulated using Neuro Solution Software. The mean
square error of CANFIS was 0.000842 [38]. N. Deepika et al. [39], suggested a heart attack patient
classification model. He pre-processed his information sets for missing values and then implemented
the same width binning interval approach. Then numerical parameters are transformed into categorical
parameters and frequent patterns are mined based on pruning-classification rule algorithm linked to heart
disease. His model used an effective forecast of particular class label [39].
T. Turner [40] proposed the idea of diagnosing heart disease by combining naïve bayes and k-means
clustering with distinct choice of centroids. Cleveland clinic foundation collects the data set. The precision of
the embedded k-k-is 84.5 percent compared to the traditional algorithm [40]. Uzma Ansari et al. [41] used
weighted associative classifier to develop a model for predicting heart attacks. The data set is gathered from
the ML database of Irvine University of California (UCI). He used 2 class labels 1 in his model for "No heart
disease" and other one for "Heart disease" rather than getting 5 class labels with 1 for no heart disease and 4
for four heart disease kinds. He used 80% of confidence value and 25% of support value. The prototype
proposed achieves precision of 81.51 percent. He concludes that the measured associative classifier is
the easiest way to acquire efficient important patterns from information setting for cardiac disease [41].
The below Table 2 shows the comparative surveyof heart disease techniques which we have discussed above.
Table 2. The comparative survey of heart disease
Authors Year Data set Methodology Accuracy
Latha Parthiban 2007 University of California Irvine (UCI) Neural network and Genetic algorithm MSE -.000842
Tsipouras M. G 2008 Invasive Cardiology, Hospital of Loannina Fuzzy Modelling and Data Mining 80%
H. A. Huijer 2010 Sensor Data SVM 91.4%
N. Deepika 2011 University of California Irvine (UCI) Pruning-Classification Association rule
Predicts
effectively
Uzma Ansari 2011 University of California Irvine (UCI) Weighted Associative Classifier 81.51%
P. K. Anooj 2012
Cleveland, Hungarian Institute of
Cardiology, University Hospital, Zurich,
Switzerland
Weighted Fuzzy rules 57.85%
Chaitrali S. 2012 Cleveland heart disease database
Naïve bayes, Neural network and
Decision tree
100%
Mai Shouman 2012 Cleveland heart disease database Centroid Selection Technique 83.9%
T. Turner 2012 Cleveland heart disease database Integrated k- means and Naïve bayes 84.5%
S. Pal 2013 Cleveland heart disease database CART, ID3, Decision Tree 83.49%

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4.2. Description of existing techniques for breast cancer prediction
A fuzzy model was created by Yassi et al. [42] to differentiate between normal and malicious breast
cancer. The technique brought disorder into the hierarchical cluster of partial swarm enhancement of
multispecies, prompting the improvement of chaotic hierarchical cluster-based multispecies swarm
enhancement of particles (CHCMSPSE). CHCMSPSE helps to distinguish the form of cancer of the breast
and to enhance the fuzzy rules. The model also discovers fuzzy rules very correctly. The dataset is gathered
from the machine learning database of Irvine University of California (UCI). Thus, for worldwide search
capability, the technique utilizes 11 chaotic maps. Sinusoidal chaotic map acquired 99 percent precision
from those maps because it matched with the position of the issue. The model achieves more than
90% precision [42].
In defining 5, 10 and 15 years of specific breast cancer sustainability, Lundin M et al. [43] provided
a prototype for accessing the precision of ANN. The data source is collected from City Hospital of Turku and
Turku University Central Hospital with 951 instances. In that training set of 651 instances and a validation
set of 300 instances. This prototype compares the outcomes of artificial neural network and logistical
regression. The precision of breast cancer specific survival for 5 years reported as 0.909,10 years reported as
0.086 and 15 years reported as 0.883 [43].
Delen D et al. [44] implemented a data mining technique comparison approach that involves
logistical regression, decision tree, and artificial neural network to predict breast cancer development.
The model utilizes over 200,000 cases of an enormous information repository. Thus, logistical regression
precision is 89.2%, decision tree precision (C5) 93.6% and artificial neural network 91.2%. 10-fold
cross-validation for information testing, unbiased estimation measurement and 3 techniques prediction.
Research indicates that the selection trees is the best determinant method for defining breast cancer growth
relative to the artificial neural network and logistic regression [44].
Bellaachia Abdelghani et al. [45] used information mining techniques to present a model for
predicting breast cancer development. The pre-classification process is carried out in three areas: recovery of
essential status, recovery of survival time and cause of death. Three techniques of machine learning, namely:
neural network propagated back, naïve bayes and C4.5 for classification performance. The data set is
gathered from the National Cancer Institute (NCI) Surveillance, Epidemiology, and End Results. There are
151.886 records in the dataset, with 16 characteristics. The model provides roughly 87% precision [45].
H. Koyuncu et al. [46] implemented a biomedical pattern based on artificial neural network
rotational forest algorithm (RF-ANN). Multilayer perceptron was used as the classifier of base and the model
used RF algorithm as the classifier of ensemble. Using the main component assessment, different function
sets are gathered from the information set. The precision of RF-ANN is therefore 98.05 percent [46].
S. M. Jamarani H et al. [47] proposed a method for recognizing the disease and helping radiologists
predict breast cancer. The model combines decomposition of artificial neural network (ANN) and sub-band
picture based on multiwavelet. The technique is studied using mammographic database by mammographic
image analysis society (MIAS). The highest output of biorthogonal Geronimo, Hardin and massopust
multiwavelet 2 (BiGHM2) was among the various kinds of multiwavelet. Thus, BiGHM2 accomplished
precision in the operating characteristic curve of the receiver around 0.96 [47].
T. Nguyen et al. [48] suggested an automatic wavelet-based technique for classifying medical
information and a type-2 fuzzy logic. They carried out execution from the UCI database for machine learning
on 2 medical datasets: Cleveland heart disease and Wisconsin breast cancer. The outcome demonstrates that,
compared to other machine learning methods, the advantage of interval type-2 fuzzy logic scheme is
better [48]. Z. Mahmud et al. [49] suggested a method to use age, marital status and therapy among
Malaysian women to find out about cervical cancer. The records of patients with cervical cancer are gathered
from the medical center of Kebangsaan Malaysia University (UKM). The model has four phases, with 444
records of patients impacted by cervical cancer, and finding out the age and marital status of women's
medical therapy. They discovered that the 46-year-old females are more likely to develop cervical cancer.
So, it is suggested that Malaysian women undergo testing prior to the age of 45 and they also found that
Chinese women under the age of 57 have more likelihood of being diagnosed with radiotherapy in
the original phase of cervical cancer [49].
M. Seera et al. [50] suggested using hybrid smart classification to classify medical information to
predict cancer. The model has a random forest, classified trees, and a regression tree and a min-max neural
network. The technique of random forest is used to create a classification and regression Tree model
ensemble. Fuzzy min-max is used for teaching purposes. The tree of classification and regression is used to
extract the rule. The precision of this model for cancer forecast was 98.84% [50].
W. Kuo et al. [51] suggested a novel technique for breast tumour prediction in clinical ultrasonic
images using the decision tree. The model concentrated on pictures from the United States. The decision tree

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uses the C5.0 algorithm. Machine learning with decision tree algorithm help predict breast tumour illness
with 93.33% responsiveness precision and 96.67% specificity precision [51].
Seon-Hak [52] constructed a prototype using rough set structures for hierarchical classification.
The model is based on the framework of hierarchical granulation to find out the laws of classification and
therefore suggested a discovery of laws. The technique is validated against the Wisconsin breast cancer
(WBC) data gathered dataset. The model still generates excellent efficiency when loaded with simple rules
and brief conditionals. Thus, by creating minimal classification rules, the model was effective in decreasing
the number of dimensions. His model makes it simpler for us to analyze the information system [52].
The below Table 3 shows the comparative study of breast cancer techniques which we have discussed above.
Table 3. The comparative survey of breast cancer
Authors Year Data set Methodology Accuracy
Lundin M 1999
Turku City Hospital and Central Hospital
of Turku University
ANN
5yrs-0.909, 10yrs-0.086
and 15yrs0.883 G
W. Kuo 2001 Machine learning repository C5.0 algorithm 96.67%
Seon-Hak Seo 2001
Wisconsin breast cancer (WBC), UCI
diabetes for Pima Indians
Hierarchical Classification 83.49%
Delen D 2005 Machine learning repository ANN and logistic regression 93.6%
Jamarani S. M. h 2005 Machine learning repository
(ANN), decomposition of
multiwavelet-based picture
sub-band
ROC-0.96
Bellaachia
Abdelghani
2006
National Cancer Institute (NCI)
surveillance, epidemiology and end
results
Data Mining Methods 87%
Uzma Ansari 2013 University of California Irvine (UCI)
Rotation forest algorithm (RF-
ANN)
98.05%
M. Seera 2014
Wisconsin breast cancer (WBC), UCI
diabetes for Pima Indians
Random forest, classified
trees and regression tree
(CART) and fuzzy neural
network min-max
98.84%
A. Yassi 2014 University of California Irvine (UCI) hierarchical-clustering 90%
T. Nguyen 2015 University of California Irvine (UCI)
Wavelets and interval type-2
fuzzy logic system (IT2FLS)
97.40%
5. CHALLENGES AND RESEARCH OPPORTUNITIES
Reviews of data mining methods, classification methods, smart methods and choice of features for
disease prediction were discussed here. As the selection of characteristics enables us to eradicate unnecessary
data, large-dimensional data must be compressed without the loss of data, which improves the effectiveness
of classification. But the difficulty of subset attribute selection is high, which is complicated as it requires
complex interdependence on a wide range of factors. We could incorporate guidelines and feature selection
for better results in the classifiers in the future. Additionally, new feature selection method such as ant colony
optimization, etc. is possible to test to improve quality, and you can attempt experimenting with algorithm
potential for most medical datasets that include distinct features such as noisy information, sparsity, missing
value, etc. to enhance model accuracy.
6. CONCLUSION
This paper's primary focus is to discuss various prediction models and techniques used for
predicting heart disease and breast cancer. The technique also sheds light on the significance in medical
dataset of various classification techniques for disease prediction. The dataset that we have discussed in so
many current methods is linked to heart and breast cancer. As a classifier, the different machine learning
methods are used to construct a value-effective model for predicting disease. It is therefore well recognized
by the exhaustive study that the extraction of the necessary data from the clinical repository helps us to
promote excellently-informed testing and choices.
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BIOGRAPHIES OF AUTHORS
Ms. G. Saranya received B.Tech degree in Information Technology from Sri Venkateswara
College of Engineering, Sriperumbudur, Chennai, India in 2009. M.Tech degree in Information
Technology from Vel Tech Multi Tech Dr.Rangarajan Dr.Sakunthala Engineering College, Avadi,
Chennai, India in 2011.She is currently pursuing her Ph.D in Computer Science and Engineering
at Sathyabama Institute of science and Technology, Chennai, India and works as Assistant
Professor in Information Technology Department at SRM Institute of Science and Technology,
India. She has 7+ years of teaching experience and 2 years of Industry Experience. Her research
interests include Big Data Analytics, Machine learning and Deep learning.
Dr. A. Pravin received the B.E degree in Computer Science & Engineering from Bharath Niketan
Engineering College, Madurai Kamaraj University, Madurai, India in 2003 , M.E degree in
Computer Science & Engineering from Sathyabama University, Chennai, India in 2005 and Ph.D
degree in Computer Science & Engineering at Sathyabama University, Chennai, India in 2014.
He works currently as an Associate Professor for the Department of Computer Science and
Engineering at Sathyabama Institute of Science and Technology, Chennai and he has 14 Years of
teaching experience. He has participated and presented many Research Papers in International and
National Conferences and also published many papers in International and National Journals.
His area of interests includes Software Engineering, Data mining , Internet of Things and Big data.

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