This thesis investigates assumptions of the Markowitz model and evaluates alternative measures for risk-adjusted return. It analyzes Swedish large cap stock returns and finds evidence against the normal distribution assumption. The Sharpe ratio is found to be unreliable due to extreme events. Modified Sharpe ratios that incorporate higher moments like skewness and kurtosis provide more stable measures of portfolio performance over time. Monthly returns best replicate future portfolio performance when considering risk and return, as they experience less variation than daily or weekly returns. Incorporating skewness into the model slightly improves performance estimation for future periods relative to the traditional Markowitz approach.