A review in the nanosensors for biosensing

Development Direction of Bio-Nano-Technology
 Rapid Detection Technology Based on New Nanomaterials
 Rapid Detection Technology Based on
Carbon Nanocomposites
 New AuNPs Colorimetric Sensor Based
on Dual Adaptor
 Trend of detection technology
 Integration
 Facilitation
 Informatization
 Intelligentize
Accurate traceability, Multiple source control,
Rapid detection Establish a long-term traceability,
prevention and control and detection mechanism.

Development of Novel Diagnostic Devices
 The Microbiome Meets Nanotechnology: Opportunities and Challenges
 Monitoring of the human microbiome
is an emerging area of diagnostics for
personalized medicine.
 Nano-biosensing: for measurement of
microbiome-related biomarkers.
• Diet, drugs
(antibiotics,
probiotics), cultural
habits…
• Age, sex, stress,
exercise, hygiene…
• Immune system,
environmental
contact, host’s
genetics…
Microbiome
change
Meta-Omics:
Biomarker
discovery
PoC
detection
Meta-Omics:
Biomarker
discovery
Early
Diagnosis,
treatment
Monitoring,
optimization
Metagenomics,
metabolomics, etc.
Symptoms
Family medical
History…
Precision medicine
Personalized medicine
By exploring the advantages and disadvantages of current nanotechnology-based approaches

 Imbalances in local microbial populations have been linked to myriad diseases.
 there is a 1:1 ratio of microbial and
human cells.
 alterations in the microbiome to various
diseases have been already associated.
Commensal Microbes: A Necessary and Ever-Changing Organ
Point-of-care biosensing devices amenable to microbiome analyses

Nanomaterials and Electrochemistry
 Examples of nano-biosensing technologies for microbiome related diagnostics
 Characteristics: size, functionalization
signal generation.
 Point-of-care biosensing devices amenable
to microbiome analyses
size in the bioreceptor scale, surface for functionalization, ability to generate a signal

Nanomaterials and Electrochemistry
 Magnetic barcode assay for genetic detection of pathogens
size in the bioreceptor scale, surface for functionalization, ability to generate a signal

Inactivated Live attenuated
Protein subunit
Viral vectored
DNA
mRNA
Virus-like particle
Nano-particle
Coronavirus
Nanoparticle vaccines induce broad protection

Plasmonic nano materials in microbe inactivation and sensing
 Localized plasmons and associated properties
of plasmonic nano metals
The photophysical mechanisms of plasmonic nano-materials are
enabled by their unique optical properties.

Principle of Raman Spectroscopy
 Raman spectra are acquired by irradiating samples with monochromatic laser source.
Raman spectrometer has unique advantages while the limitation will still be noted.

SERS Probes for Rapid Detection of Bacteria
 SOTs were demonstrated to be effective for
detection of live E. coli in suspension.
The first demonstration of detection of live, unlabeled bacteria using a SERS probe.

SERS Assay for Multidrug-Resistant Bacteria
 PCR: multiple steps, long operation time, complex primer. HOW TO OVERCOME?
CRISPR/Cas9 mediated SERS can be expanded to diagnose a wide array of pathogens

Detection of Quorum Sensing in Communities by SERS
 QS has become intensively studied topics during the past few decades.
SERS serve as general detection systems for the investigation of cellular communication

Summary and References
1. G. Bodelón, et al. Nature Material. 2016, 15,
1203 - 1211.
2. T. Yang, et al. Journal of Dairy Science, 2020,
103(9): 7879 - 7889.
3. H. Kim, et al. ACS Nano, 2020, 14(12): 17241 -
17253.
4. C. Fuentes Chust,
‐ et al. Advanced Materials, 2021:
2006104.
5. J. A. Kim, et al. Advanced Optical Materials, 2020,
8(9): 1901934.
6. X. An, et al. Nanoscale, 2021, 13(6): 3374 - 3411.
7. M. S. Mannoor, et al. Nature Communications, 2012,
3(1): 1 - 9.
8. M. Liong, et al. Nature Communications, 2013, 4(1):
1 - 9.
9. S. Boyoglu-Barnum, et al. Nature, 2021

A review in the nanosensors for biosensing

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Editor's Notes