This doctoral research explores how users make sense of and use information when seeking information from web-based resources. The research examines user behaviors and strategies as they interact with information sources to identify examples of how users collect, evaluate, understand, interpret, and integrate new information. Three empirical studies were conducted involving participants completing information seeking tasks. The results provide insights into users' information interaction strategies and sensemaking activities. Implications for the design of technologies to better support sensemaking are discussed.