Using basic commands of network simulation, we can: 1) Enter enable mode by pressing enter at the router console to enable commands, typing "enable", and entering the enable prompt. 2) View the OS version, memory, and RAM using the "show version" command in user mode where files can be viewed but not edited. 3) Open configuration mode using "configure terminal" to configure interfaces like serial or Ethernet ports by specifying the interface name and assigning an IP address, subnet mask, and bringing the interface up with "no shutdown".