The document provides a comprehensive overview of various airway clearance techniques and devices, including their indications, contraindications, and methodologies such as postural drainage, active cycle of breathing techniques, and mechanical ventilation support. It discusses specific devices like High-Frequency Chest Wall Oscillation and Oscillatory Positive Expiratory Pressure, highlighting their mechanisms, effectiveness, and cost-effectiveness in managing respiratory conditions. Clinical studies mentioned indicate that certain devices, like the Aerobika OPEP, may significantly improve patient outcomes in terms of lung function and quality of life, particularly for individuals with severe COPD and bronchiectasis.