The Cell Cycle-
Mitosis and Meiosis
Interphase- G1, S, G2
Mitosis or Meiosis
The Cell Cycle
 The sequence of growth and
division of a cell
AP Cell Cycle-Mitosis and Meiosissss.ppt
Interphase = G1, S, G2
 Interphase is when the cell grows,
and the organelles double prior to
the actual splitting of the nucleus.
 93% of a cell’s life is spent in
interphase.
 Interphase has three parts
 Growth 1 (G1)
 Synthesis (S)
 Growth 2 (G2)
G1, S, G2
 G1 is when organelles double.
 Remember each new cell needs a
complete set of organelles.
 S when DNA is replicated.
 Each cell needs a complete and
identical set of DNA
 G2 Proteins needed for Mitosis are
produced.
Mitosis
 The process by which the cell nucleus divides
into two identical cell nuclei.
 In some Human cells interphases lasts 15.3
hours, while mitosis lasts only .7 hours.
 Occurs in a series of steps
 Prophase
 Metaphase
 Anaphase
 Telophase
 Cytokinesis
Chromosomes
 Must duplicate and separate during
Mitosis
 Structures of the tightly packaged
DNA
 DNA is tangled up into a substance
of chromatin
 The chromatin is packaged on the
chromosome
Chromosomal structure
Prophase
 Chromosomes now called chromatids because
they doubled to form short thick rods which pair
up and line up in the center of the nucleus.
 A centromere connects the two halves of the
doubled chromatids.
 Spindle fibers begin to form.
 Spindle fiber – a fibrous structure from the
cytoplasm which forms to the centriole.
 Centrioles move to opposite sides of the cell.
 The nuclear membrane breaks down.
Prophase
Metaphase
 Centromeres of the chromatid pairs line up in
the middle of the cell.
 Metaphase plate- location where the
centromeres line up in the center of the cell.
 By the end of metaphase each chromatid has
attached to spindle fibers.
Metaphase
Anaphase
 The spindle fibers pull the
chromatids apart.
 This separates each one from its
duplicate. These move to opposite
sides of the cell.
 Now there are two identical sets of
chromosomes.
Anaphase
Telophase
 When the chromosomes reach
opposite sides of the cell the
spindle fibers break up.
 The nuclear membrane begins to
reform.
 A furrow begins to develop
between the two sets of
chromosomes.
Telophase
Cytokinesis
 The two identical cells completely
divide and the cell membrane is
completely formed.
Mitosis Movie 1
Mitosis movie 2
Meiosis
 Diploid (2n) - A cell with two of each kind of
chromosome.
 One chromosome from each parent.
 If two body cells were to combine nuclei, the
number of chromosomes would double.
 In order for sexual reproduction to occur, each
cell involved must reduce its chromosome
number by half.
 Haploid (n)- A cell with one of each kind of
chromosome.
Haploid cells
 Haploid cells are called gametes
 Gametes are either sperm or eggs
 Organism diploid gamete
 Human 46 23
 Pea 14 7
 Fruit fly 8 4
 Dog 78 39
Homologous chromosomes
 Are paired chromosomes with genes for the
same trait arranged in the same order.
 Ex. Eye color, hair color, height, one may
code for blue, blonde, tall, its homolog may
code for brown, blonde, short
 Homologous chromosomes may have
different alleles on them
 Allele- gene form for each variation of a trait
of an organism.
Meiosis
 Meiosis is the process of cell division in which
gametes are formed and the number of
chromosomes is halved. So that sexual
reproduction and zygote formation can occur.
 Zygote- Fertilized egg which has a diploid
number of chromosomes.
Stages of Meiosis
 Interphase-
 Chromosomes replicate
 Each chromosome consists of 2 identical sister
chromatids
 Prophase I
 Each Pair of homologous chromosomes come
together to form a tetrad.
 Tetrad- 2 homologous chromosomes come
together and the 4 chromatids overlap.
Crossing over
Tetrads are so tight that non-sister chromatids
from the homologous pair actually exchange
genetic material.
 Crossing over- The exchange of genetic
material by non-sister chromatids during late
prophase I of meiosis.
 Results in a new combination of alleles
Metaphase I
 Homologous chromosomes line up together in
pairs.
 * In mitosis homologous chromosomes line up in
the middle independently of each other.
Anaphase I
 Spindle fibers attach to the centromeres of
each pair.
 Homologous chromosomes separate and
move to opposite ends of the cell.
 Centromeres DO NOT split like they do in
mitosis
 Now each cell will get one chromosome from
each homologous pair.
Telophase I
 Spindle fibers break down
 Chromosomes uncoil
 Cytoplasm divides
 Another cell division is needed because the
number of chromosomes has not been reduced
 After telophase I there maybe a short
interphase, but not always. It is important to
note that if a cell does have a second
interphase, there is No replication of
chromosomes.
Meiosis I
Meiosis II
 Is basically just like mitosis, but remember the
chromosomes did not duplicate in interphase II.
 Prophase II
 Chromosomes begin to line up in the middle of the
cell.
 Spindle fibers begin to form
 Metaphase II
 Chromosomes line up on the metaphase plate
Meiosis II
 Anaphase II
 Centromeres split
 Sister chromatids separate and move to opposite
sides of the cell
 Telophase II
 Nuclei reform
 Spindle fibers disappear
 Cytoplasm divides into two.
 The number of chromosomes in each daughter
cell has now been reduced by half.
Meiosis II
Meiosis Movie 1

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AP Cell Cycle-Mitosis and Meiosissss.ppt

  • 1. The Cell Cycle- Mitosis and Meiosis Interphase- G1, S, G2 Mitosis or Meiosis
  • 2. The Cell Cycle  The sequence of growth and division of a cell
  • 4. Interphase = G1, S, G2  Interphase is when the cell grows, and the organelles double prior to the actual splitting of the nucleus.  93% of a cell’s life is spent in interphase.  Interphase has three parts  Growth 1 (G1)  Synthesis (S)  Growth 2 (G2)
  • 5. G1, S, G2  G1 is when organelles double.  Remember each new cell needs a complete set of organelles.  S when DNA is replicated.  Each cell needs a complete and identical set of DNA  G2 Proteins needed for Mitosis are produced.
  • 6. Mitosis  The process by which the cell nucleus divides into two identical cell nuclei.  In some Human cells interphases lasts 15.3 hours, while mitosis lasts only .7 hours.  Occurs in a series of steps  Prophase  Metaphase  Anaphase  Telophase  Cytokinesis
  • 7. Chromosomes  Must duplicate and separate during Mitosis  Structures of the tightly packaged DNA  DNA is tangled up into a substance of chromatin  The chromatin is packaged on the chromosome
  • 9. Prophase  Chromosomes now called chromatids because they doubled to form short thick rods which pair up and line up in the center of the nucleus.  A centromere connects the two halves of the doubled chromatids.  Spindle fibers begin to form.  Spindle fiber – a fibrous structure from the cytoplasm which forms to the centriole.  Centrioles move to opposite sides of the cell.  The nuclear membrane breaks down.
  • 11. Metaphase  Centromeres of the chromatid pairs line up in the middle of the cell.  Metaphase plate- location where the centromeres line up in the center of the cell.  By the end of metaphase each chromatid has attached to spindle fibers.
  • 13. Anaphase  The spindle fibers pull the chromatids apart.  This separates each one from its duplicate. These move to opposite sides of the cell.  Now there are two identical sets of chromosomes.
  • 15. Telophase  When the chromosomes reach opposite sides of the cell the spindle fibers break up.  The nuclear membrane begins to reform.  A furrow begins to develop between the two sets of chromosomes.
  • 17. Cytokinesis  The two identical cells completely divide and the cell membrane is completely formed.
  • 20. Meiosis  Diploid (2n) - A cell with two of each kind of chromosome.  One chromosome from each parent.  If two body cells were to combine nuclei, the number of chromosomes would double.  In order for sexual reproduction to occur, each cell involved must reduce its chromosome number by half.  Haploid (n)- A cell with one of each kind of chromosome.
  • 21. Haploid cells  Haploid cells are called gametes  Gametes are either sperm or eggs  Organism diploid gamete  Human 46 23  Pea 14 7  Fruit fly 8 4  Dog 78 39
  • 22. Homologous chromosomes  Are paired chromosomes with genes for the same trait arranged in the same order.  Ex. Eye color, hair color, height, one may code for blue, blonde, tall, its homolog may code for brown, blonde, short  Homologous chromosomes may have different alleles on them  Allele- gene form for each variation of a trait of an organism.
  • 23. Meiosis  Meiosis is the process of cell division in which gametes are formed and the number of chromosomes is halved. So that sexual reproduction and zygote formation can occur.  Zygote- Fertilized egg which has a diploid number of chromosomes.
  • 24. Stages of Meiosis  Interphase-  Chromosomes replicate  Each chromosome consists of 2 identical sister chromatids  Prophase I  Each Pair of homologous chromosomes come together to form a tetrad.  Tetrad- 2 homologous chromosomes come together and the 4 chromatids overlap.
  • 25. Crossing over Tetrads are so tight that non-sister chromatids from the homologous pair actually exchange genetic material.  Crossing over- The exchange of genetic material by non-sister chromatids during late prophase I of meiosis.  Results in a new combination of alleles
  • 26. Metaphase I  Homologous chromosomes line up together in pairs.  * In mitosis homologous chromosomes line up in the middle independently of each other.
  • 27. Anaphase I  Spindle fibers attach to the centromeres of each pair.  Homologous chromosomes separate and move to opposite ends of the cell.  Centromeres DO NOT split like they do in mitosis  Now each cell will get one chromosome from each homologous pair.
  • 28. Telophase I  Spindle fibers break down  Chromosomes uncoil  Cytoplasm divides  Another cell division is needed because the number of chromosomes has not been reduced  After telophase I there maybe a short interphase, but not always. It is important to note that if a cell does have a second interphase, there is No replication of chromosomes.
  • 30. Meiosis II  Is basically just like mitosis, but remember the chromosomes did not duplicate in interphase II.  Prophase II  Chromosomes begin to line up in the middle of the cell.  Spindle fibers begin to form  Metaphase II  Chromosomes line up on the metaphase plate
  • 31. Meiosis II  Anaphase II  Centromeres split  Sister chromatids separate and move to opposite sides of the cell  Telophase II  Nuclei reform  Spindle fibers disappear  Cytoplasm divides into two.  The number of chromosomes in each daughter cell has now been reduced by half.