This document summarizes API STD 521 Part-I, which provides guidance on overpressure protection for refinery equipment. It discusses overpressure causes and protection philosophies. It also lists the minimum recommended contents for relief system designs and flare header calculations. These include analyzing overpressure causes, operating conditions, relief device sizing, and documentation of simulation inputs and outputs. Various overpressure causes are outlined, such as closed outlets, absorbent or cooling failures, accumulation of non-condensables, abnormal heat input, explosions, and depressurizing. Protection measures against these causes like relief valves, rupture disks, and explosion prevention are also mentioned.