The document discusses the science behind runtime application self-protection (RASP) and interactive application security testing (IAST). It describes how RASP works by instrumenting application code to perform dynamic taint analysis, tracking tainted data from inputs and checking for policy violations at sinks like database queries. IAST similarly instruments code but also correlates runtime behavior with attacks to confirm vulnerabilities. The document outlines challenges with taint analysis like under-tainting causing false negatives or over-tainting causing false positives. Both RASP and IAST add overhead, and IAST also has limitations of traditional dynamic application security testing.