This study evaluates the effects of various rainfall interpolation methods (Theissen polygon, Inverse Distance Weighted (IDW), and Ordinary Kriging) on streamflow simulation in the Vamanapuram River basin in Kerala, India, utilizing the Shetran hydrologic model. Results indicate that both IDW and Ordinary Kriging perform better than Theissen polygon in accurately simulating mean annual streamflow, particularly in regions with sparse rain gauge networks. The study emphasizes the importance of selecting appropriate spatial interpolation techniques for improving hydrologic modeling outcomes.