This document provides guidance on effectively communicating scientific information to different audiences. It prompts the user to identify their scientific questions, which elements to highlight, why the information matters to the audience, potential benefits, and key takeaways. An example response is given for a scientific audience focused on bacteria roles in carbon cycling and climate change. Another example is given for a K-12 student audience highlighting that bacteria have different functions and populations in various environments. The takeaway emphasizes that more bacteria are helpful than harmful.