This document provides guidance on effectively communicating science to different audiences. It instructs the reader to identify the key scientific questions, elements to highlight, why the information matters to the audience, potential benefits, and 2-3 key messages. An example is given for communicating about bacteria populations and environmental conditions to both a scientific and K-12 student audience. The example emphasizes that more bacteria are helpful than harmful and that bacteria play important roles in nutrient cycling and supporting life.