Amazon Route 53 is AWS's managed DNS service that allows users to register domain names and route internet traffic to resources like websites, applications, and servers. It provides advanced routing policies, a global network, integration with other AWS services, health checks, and DDoS protection. Route 53 uses traffic flow policies to direct users to endpoints based on factors like latency, geography, and endpoint health. It also supports private DNS to route traffic within a user's VPCs without exposing DNS records publicly.