This document discusses policy informatics at a societal scale for massively interactive socially-coupled systems. It argues that policy modeling must be responsive to evidence-based policymaking and end simplistic prediction models. With embedded computing and social networks, individual reasoning is socially influenced. It proposes using synthetic data and simulations of interacting individuals and infrastructure to model these complex systems, while preserving privacy. This would involve generating synthetic populations and networks that represent regional interactions and integrate with built systems.