Multiple regression analysis allows a dependent variable to be explained by multiple independent variables simultaneously. This overcomes limitations of simple regression by explicitly controlling for other factors that may affect the dependent variable. The key assumptions is that the error term has a conditional mean of zero given all independent variables. Estimating the coefficients involves minimizing the sum of squared errors to obtain estimated coefficients using ordinary least squares. The estimated coefficients can then be interpreted as measuring the partial effect of each independent variable on the dependent variable, holding other independent variables fixed.