CADASTER
1 like400 views
This document discusses the CADASTER project which aims to integrate information, models, and strategies for safety assessment and risk assessment of large numbers of substances according to the REACH framework. The project will develop decision support systems for chemical hazard and risk assessment of emerging chemicals classes using non-animal testing methods like QSAR models, read-across, and exposure scenarios. It involves collecting data, developing and validating QSAR models, integrating models into risk assessments, and providing policy recommendations.
CADASTER
- 1. F T ra n sf o F T ra n sf o PD rm PD rm Y Y Y Y er er ABB ABB y y bu bu 2.0 2.0 to to re re he he k k lic lic C C w om w om w w w. w. A B B Y Y.c A B B Y Y.c CAse studies on the Development and Application of in-Silico Techniques for Environmental hazard and Risk assessment Willie Peijnenburg RIVM – Laboratory for Ecological Risk Assessment willie.peijnenburg@rivm.nl
- 2. F T ra n sf o F T ra n sf o PD rm PD rm Y Y Y Y er er ABB ABB y y bu bu 2.0 2.0 to to re re he he k k lic lic C C w om w om w w w. w. A B B Y Y.c A B B Y Y.c CADASTER Classification of PFOS- compounds in 22 categories according to PBDE: "The PCB's of the future" OECD Pharmaceuticals and Personal Care Products in Microbicidal benzotriazoles the Environment: Agents of Subtle Change?
- 3. F T ra n sf o F T ra n sf o PD rm PD rm Y Y Y Y er er ABB ABB y y bu bu 2.0 2.0 to to re re he he k k lic lic C C w om w om w w w. w. A B B Y Y.c A B B Y Y.c REACH Registration, Evaluation, Authorisation and Restriction of Chemicals REACH requires demonstration of safe manufacture and use of chemicals REACH based on precautionary principle, aims at achieving proper balance between social, economic and environmental objectives REACH aims to optimise the use of scarce and scattered info on substances REACH aims to minimise animal testing by optimal use of info on “related” compounds
- 4. F T ra n sf o F T ra n sf o PD rm PD rm Y Y Y Y er er ABB ABB y y bu bu 2.0 2.0 to to re re he he k k lic lic C C w om w om w w w. w. A B B Y Y.c A B B Y Y.c REACH Minimised animal use: 1 – Use of validated in silico techniques: (Q)SAR/(Q)SPR 2 – New in vitro test methods, in vivo info analogues 3 – Minimization actual numbers of animals used, and replacement of animal tests by alternative methods 4 – Substance Information Exchange Forums (SIEFs) for obligatory provision of data and cost sharing 5 - Requirement of official sanctioning of proposals for tests for compounds with production volumes of above 100 tonnes to minimize animal testing
- 5. F T ra n sf o F T ra n sf o PD rm PD rm Y Y Y Y er er ABB ABB y y bu bu 2.0 2.0 to to re re he he k k lic lic C C w om w om w w w. w. A B B Y Y.c A B B Y Y.c Intelligent Testing Strategies (ITS) Read Across (Q)SARs In-vitro Endpoint information Exposure Scenarios Existing (Annex VII/VIII) ? information TESTING Constituents of an Intelligent (or Integrated) Testing Strategy (ITS). Taken from a presentation of K. van Leeuwen and S. Bradbury: “REGULATORY RISK ASSESSMENT: Trends and paradigm shifts are needed” - European Commission & USEPA.
- 6. F T ra n sf o F T ra n sf o PD rm PD rm Y Y Y Y er er ABB ABB y y bu bu 2.0 2.0 to to re re he he k k lic lic C C w om w om w w w. w. A B B Y Y.c A B B Y Y.c CADASTER Goals: Exemplify the integration of information, models, strategies for safety- hazard- safety-, hazard-, risk assessment for large numbers of substances Carry out “real” risk assessment for large numbers of substances according to the basic philosophy of REACH: < costs, animal testing, time Exemplify how to increase non- non- testing information whilst quantifying and reducing uncertainty
- 7. F T ra n sf o F T ra n sf o PD rm PD rm Y Y Y Y er er ABB ABB y y bu bu 2.0 2.0 to to re re he he k k lic lic C C w om w om w w w. w. A B B Y Y.c A B B Y Y.c CADASTER Aim: Aim: Provide full environmental hazard and risk assessment according to the REACH philosophy for chemicals belonging to 4 classes of emerging chemicals: 1 – Polybrominated diphenylethers (PBDE), typically class of hydrophobic chemicals that pose a threat to man and the environment. 2 - Perfluoroalkylated substances and their transformation products, like perfluoroalkylated sulfonamides, alkanoic acids, sulfonates. Persistent hydrophilic compounds that may be toxic for man and environment. 3 – Substituted musks/fragrances; a heterogenic group of chemicals of varying composition like substituted benzophenones, polycyclic musks, terpene derivatives. Common emission pattern in the environment. 4 - Triazoles/benzotriazoles: increasingly used as pesticides and anti-corrosives. anti-
- 8. F T ra n sf o F T ra n sf o PD rm PD rm Y Y Y Y er er ABB ABB y y bu bu 2.0 2.0 to to re re he he k k lic lic C C w om w om w w w. w. A B B Y Y.c A B B Y Y.c CADASTER Outcome: Outcome: DSS – regularly updated for new compound classes: -New testing strategies -New testing data -New models -Actual integrated evaluations, including uncertainty and variability - On- On-line and stand-alone tool stand-
- 9. F T ra n sf o F T ra n sf o PD rm PD rm Y Y Y Y er er ABB ABB y y bu bu 2.0 2.0 to to re re he he k k lic lic C C w om w om w w w. w. A B B Y Y.c A B B Y Y.c PARTNERS W Pe W. Peijnenburg ij n e nb urg (Coordinator) M. Huijbregts M. Durjavaa j P. Gramatica A. Woldegiorgis E F u rus jö T. Öberg T Ö b erg I. Tetko I Te t k o N. Jeliazkova N Je li azk o v a M. Comber
- 10. F T ra n sf o F T ra n sf o PD rm PD rm Y Y Y Y er er ABB ABB y y bu bu 2.0 2.0 to to re re he he k k lic lic C C w om w om w w w. w. A B B Y Y.c A B B Y Y.c Beneficiary Beneficiary name Beneficiary Coun Number * short name try 1 Rijksinstituut voor RIVM Nl (coordinator) Volksgezondheid en Milieu (RIVM) 2 Public Health Institute PHI Si Maribor 3 University of Insubria UI Italy (Varese) 4 IVL Swedish IVL S Environmental Research Institute 5 University of Kalmar HIK S 6 Helmholtz Zentrum HMGU Ge München - German Research Center for Environmental Health (GmbH) 7 Ideaconsult Ltd. IDEA Bu 8 Radboud University RUN Nl Nijmegen 9 Mike Comber Consulting MCC Be
- 11. F T ra n sf o F T ra n sf o PD rm PD rm Y Y Y Y er er ABB ABB y y bu bu 2.0 2.0 to to re re he he k k lic lic C C w om w om w w w. w. A B B Y Y.c A B B Y Y.c Objectives - Work packages 1: Collection of data and models - Experimental data intrinsic hazards – Screening Initial Data Set Dossier (SIDS) - Models – Screening Initial Data Set Dossier (SIDS) - Generation new data essential for validation and proper hazard/risk assessment - Database data/models: dissemination purposes
- 12. F T ra n sf o F T ra n sf o PD rm PD rm Y Y Y Y er er ABB ABB y y bu bu 2.0 2.0 to to re re he he k k lic lic C C w om w om w w w. w. A B B Y Y.c A B B Y Y.c Objectives - Work packages 2: Development/validation QSAR models - Evaluate performance - Similarity analysis and multivariate ranking methods for identification of priority chemicals to orient the experimental testing - Develop new QSARs where gaps are identified due to lack of existing models or due to models of insufficient quality. - Documentation of the performance of the (final) models selected and developed.
- 13. F T ra n sf o F T ra n sf o PD rm PD rm Y Y Y Y er er ABB ABB y y bu bu 2.0 2.0 to to re re he he k k lic lic C C w om w om w w w. w. A B B Y Y.c A B B Y Y.c Objectives - Work packages 3: Integration of QSARs within hazard and risk assessment - Integration in probabilistic risk assessment framework: characterize variability/ uncertainty, sensitivity analyses with regard to contributions in overall risk assessment framework, modelling of variability with regard to application in SSDs - Evaluate ECETOC TRA screening risk assessment tool - Evaluate methods and decision points for establishing scientific validity and applicability domains for QSAR models - Explore possibilities for economic valuation of substitution of chemicals from within chemical classes
- 14. F T ra n sf o F T ra n sf o PD rm PD rm Y Y Y Y er er ABB ABB y y bu bu 2.0 2.0 to to re re he he k k lic lic C C w om w om w w w. w. A B B Y Y.c A B B Y Y.c Objectives - Work packages 3 (cont.): Integration of QSARs within hazard and risk assessment - Policy and management: provision of recommendations on a viable management strategy for optimized testing and in-silico modelling of in- hazardous organic substances.
- 15. F T ra n sf o F T ra n sf o PD rm PD rm Y Y Y Y er er ABB ABB y y bu bu 2.0 2.0 to to re re he he k k lic lic C C w om w om w w w. w. A B B Y Y.c A B B Y Y.c Objectives - Work packages 4: Outreach: website, newsletters/ workshops, stand-alone tools for stand- dissemination of project results - Development of on-line, stand-alone on- stand- DSS: develop, publish, use QSAR/QSPR models for REACH - Integration of the developed models with the QSAR Application Toolbox developed by OECD: establish the com- com-patibility of the models with the (Q)SAR Model Reporting Format (QMRF) format - Provision of a sustainable dissemination of project results by the WWW and as stand-alone tools stand- - Communication including newsletters and workshop(s).
- 16. F T ra n sf o F T ra n sf o PD rm PD rm Y Y Y Y er er ABB ABB y y bu bu 2.0 2.0 to to re re he he k k lic lic C C w om w om w w w. w. A B B Y Y.c A B B Y Y.c Management