![Team
Core Team
Prof B Jayaram : Director & Cofounder
Mr. Sahil Kapoor : Director & Cofounder(Head, Global Business Operations)
Mr. Avinash Mishra : Director & Cofounder(Head, R&D Operations)
Dr. Sharad Gupta : Sr. Scientist (Head, Chemistry Division)
Dr. Braham Prakash : Sr. Scientist ( Chemistry Division)
Scientific Advisors
Dr. Chinmoy De : Prof, School of Biological Sciences [IITD]
Dr. Aditya Mittal : Associate Prof ., School of Biological Sciences[IITD]
Dr. Puneet Kacker : Fellow.[Drug Discovery Dept.], Italian Institute of Italy
© 2012 Novo Informatics](https://image.slidesharecdn.com/caddatnovoinformatics-13306926843368-phpapp02-120302065656-phpapp02/85/CADD-At-Novo-Informatics-14-320.jpg)
CADD At Novo Informatics
- 1. Accelerate Drug Discovery with Novo Informatics www.novoinformatics.com Incubated : IIT Delhi © 2012 Novo Informatics
- 2. Why CADD? Faster, Cheaper and Reliable Computational studies are helpful to answer questions which remained unanswered from experimental methods CADD introduces more exciting and intuitive approach to Drug Discovery Computational scientists now work shoulder-to-shoulder with Experimentalist CADD has become a part of every pharmaceutical Research and Development unit © 2012 Novo Informatics
- 3. Who We Are A leading Drug Discovery startup incubated in IITD We believe in innovation, speed and excellence in execution Our mission is to achieve our objectives in an environment of transparency, honesty, and courtesy towards our clients and employees We are committed for the betterment of human health and their quality of life We are currently looking for global partners and collaborators © 2012 Novo Informatics
- 4. Our Expertise Analysis and modeling of target protein structure Active site prediction & Virtual screening Fragment-based design Hit-to-lead optimization Prediction of off-target susceptibility Customized chemical library design (library enumeration) ADMET Prediction Custom Molecule Synthesis Library synthesis Peptide Synthesis © 2012 Novo Informatics
- 5. Our Discovery Pipeline Target Selection Single target Dual target: polypharmacology Libraries : Screening Chemical Library Fragment library(Bioactive) Focused library & targeted library Synthetically approved molecule library Diverse Scaffold identification Prioritize Hits Off target Susceptibility Molecule synthesis BioAssay based Identification of Hit Hit Optimization Hit evolution Fragment expansion Hit-To-Lead Iterative Cycles (Validations) © 2012 Novo Informatics
- 6. Our Asset: chemical libraries A comprehensive collection of multi-million drug-like Chemical Libraries commercially available compounds available for direct screening(million+) A collection of nearly 5000 unique fragments Separate libraries for Proteases, Kinases, Ion- Customized channels, Phosphatases, transp Fragments orters etc. Target Specific American standards approved Open commercial libraries © 2012 Novo Informatics
- 7. Technology Active Site Selection Module Unique Molecule libraries DRUGONOV Customized filtering Optimized package for ADME predictions © 2012 Novo Informatics
- 8. Unique Disciplines Considering receptor plasticity by utilizing Multiple Receptor Conformation based Virtual High-throughput Screening Polypharmacology: designing compound which can work against more than one target. A method suitable for complex diseases such as Alzheimer’s Disease Library synthesis: Synthesizing compounds as well as library of analogues for experimental purpose © 2012 Novo Informatics
- 9. Facilities Computing Engine Software Purpose ProteoNov Protein structure prediction DRUGONOV A complete screening package BAPPL Binding affinity prediction Computing power: The Supercomputing Facility for Bioinformatics & Computational Biology (SCFBio), IIT Delhi Experimental set up for undergoing compound synthesis and validations © 2012 Novo Informatics
- 10. Services • Target Optimization • Screening & Bioassay based Hit Identification • Hit to Lead Optimization(Iterative cycles) • Molecule Synthesis • Peptide Synthesis • Phyto/Plant Chemistry © 2012 Novo Informatics
- 11. Working • Exchange -Confidential Agreement s Methodology Disclosure • • Consulting Agreements Disclosure of invention/Discovery • Target – Analysis • Expert Opinions (Client side) Clarify • Mode of research • Target – Analysis Simplify • Expert Opinions • Suitable Methodology • Possible opinions • Implementation • Interim reports Closure • Result reports to Client © 2012 Novo Informatics
- 12. Clients MBiotech, UK Project– Molecular Designing & Validations Status–Successfully completed Adhaere Pharmaceuticals, USA Ellis Fischel Cancer Centre, Columbia, USA Project–Molecular Screening Project–Complete Drug Discovery Project Status–Ongoing Status–Ongoing © 2012 Novo Informatics
- 13. Collaborations Griffith University IIT Delhi SCFBIO,IITD Australia © 2012 Novo Informatics
- 14. Team Core Team Prof B Jayaram : Director & Cofounder Mr. Sahil Kapoor : Director & Cofounder(Head, Global Business Operations) Mr. Avinash Mishra : Director & Cofounder(Head, R&D Operations) Dr. Sharad Gupta : Sr. Scientist (Head, Chemistry Division) Dr. Braham Prakash : Sr. Scientist ( Chemistry Division) Scientific Advisors Dr. Chinmoy De : Prof, School of Biological Sciences [IITD] Dr. Aditya Mittal : Associate Prof ., School of Biological Sciences[IITD] Dr. Puneet Kacker : Fellow.[Drug Discovery Dept.], Italian Institute of Italy © 2012 Novo Informatics
- 15. Thank You © 2012 Novo Informatics