Cdd collaborative molecular registration and sar database
- 1. A Web-Based Collaborative Drug Discovery Platform Barry Bunin, Ph.D. CEO and President Collaborative Drug Discovery, Burlingame, CA. www.collaborativedrug.com © 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate Copyright © 2011 All Rights Reserved Collaborative Drug Discovery
- 2. CDD for Private, Collaborative, & Public Research • Users: 21,197 unique logins last year (scalable in the cloud) • Interoperability/Standards: csv/SMILES, sdfiles, PubMed, ChemSpider-Pubchem, REST Based Architecture for APIs • Employing technology to facilitate partnerships: both pre- and post-IP agreements supported • Expanding the precompetitive space: the key is supporting traditional (IP sensitive), collaborative (pre-IP), and open (post-IP) – all these are real use cases © 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate Copyright © 2011 All Rights Reserved Collaborative Drug Discovery
- 3. © 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate
- 4. CDD Platform For Collaborating with IP Sensitive SAR Data © 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate Copyright © 2009 All Rights Reserved Collaborative Drug Discovery
- 5. Data Partitioning for Multiple Collaborations Consolidated CDD DB Pr oj Proj tB A j e ct ec e ct D ec Company A Pro tC oj Pr Collaborator 1 Collaborator 2 Collaborator 3 Collaborator 4 © 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate Copyright © 2009 All Rights Reserved Collaborative Drug Discovery
- 6. Collaborative Capabilities for Efficient International Drug Discovery Individual Pain Points Organizational Need Technical Solution Keep scientist’s data Collaboration is as much Temporal data access private until ready to about more efficient work controls share (i.e. with the rest of within a single their groups) organization as between organizations. Allow scientists to Control of chemical or Spatial data partitioning partition or sequester data biological data access to enable selective data based on Project-specific sharing permissions Allow collaboration in Control based on type of Sequester by data scientist’s natural data – especially given a classification workflow (i.e. without marketplace with uploading data multiple specialization in times in multiple places) synthesis, screening, discovery, development © 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate Copyright © 2011 All Rights Reserved Collaborative Drug Discovery
- 7. User Roles and Privileges in CDD © 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate
- 8. CDD Convenient Mining & Export Options © 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate
- 9. CDD Configurable IC50 Dose Response Capabilities © 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate
- 10. © 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate
- 11. Secure and Low TCO (Total Cost of Ownership) CDD database system • Web based (log in securely into to your database from any computer). • We host the server for you • Highly secure, all traffic encrypted, server in a secure professionally hosted environment. © 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate Copyright © 2009 All Rights Reserved Collaborative Drug Discovery
- 12. CDD Drug Repurposing 2009 Case Study #1 Result New leads reveal known drugs that reverse chloroquine resistance © 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate
- 13. CDD 2011 EU PPP Case Study #2 © 2009 Collaborative Drug Discovery, Inc. Archive, Mine, Collaborate