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OPEN INNOVATION
               – a primer
            An interactive workshop
           bringing insights from the
          life science and IT sectors
Jackie Hunter, Elisabeth Goodman, Michael Barnes - OI Pharma Partners

        Granta Park, Cambridge, 11 Nov 2011 (#OICambs11Nov)



                               pharma partners                          1
                                open innovation in bioscience
Goals for today

1. Dispel some of the hype that surrounds open
   innovation
2. Explore key themes
  –   Take a practical approach
  –   Mix of presentations, break-out exercises, case
      studies and discussion




                         pharma partners                 2
                         open innovation in bioscience
A little background on
             OI Pharma Partners
• Founded in 2010 by Dr Jackie Hunter
• Focus on adding value to Healthcare industries by
  realising the power of Open Innovation
   – Working with life science and healthcare companies on OI
     strategy and implementation
   – Developing OI in Healthcare strategy with EU Cyprus presidency
   – Member of OI consortia
• What we offer*:
   – Strategy – diagnosis, and development
   – Implementation – accessing networks / partners, best practices
     in collaborative project management
   – Intermediary – IP brokering, novel ideas / technologies
   Combined with scientific expertise..
                              pharma partners                 *see flyer for more details
                                                                                     3
                              open innovation in bioscience
Topics for today
                        (broad timings)
09:30 – 09:45 Introduction (Louise Rushworth, Elisabeth Goodman)
09:45 – 10:15    What is meant by Open Innovation (Mike Barnes)
10:15 – 10:45    What Open Innovation can mean for you (Jackie Hunter)
10:45 – 11:30    How OI differs between large and small organisations,
                 providers and consumers: barriers & enablers (Jackie Hunter)
11:30 – 12:00    The ideal OI Ecosystem (Mike Barnes)
12:00 – 13:00    Discussions over lunch: What participants might do as
                 next steps within / outside their organisations to
                  implement OI as a strategy to create more value




                                      pharma partners                    4
                                      open innovation in bioscience
1. What is meant by OI?
   What are the key principles?
             (Mike)
• Do we have the same understanding?


                                                  Flip chart exercise




                  pharma partners                                       5
                  open innovation in bioscience
“The lab is my world”




“The world is my lab”
A mindset based on trust
Dare to share future profits (or
losses)



                                   pharma partners                            6
                                   open innovation in bioscience
The Innovation Continuum




Internal R&D




               pharma partners                 7
               open innovation in bioscience
More than one model for Open
         Innovation

 OPEN INNOVATION
         COMPETITIVE:
            IP Model

       PRE-COMPETITIVE:
        Open Access Model



             pharma partners                  8
              open innovation in bioscience
IP strategies used in Healthcare
IP Strategy              Description                                  Examples
                         Rapid release of data into public databases; Human Genome; Open Access
Open Data Access         sometimes with an embargo period             journals, Chembl, Arch2POCM
                         Non-exclusive, royalty-free licenses; Not Open BioSystems; Biomarkers
Non-exclusive License    commercially exploitable.                    Consortium
                         licenses that enable researchers to keep
                         their copyright but allow others to copy
                         and distribute the work provided that
                         credit is assigned in accordance with        International Molecular
Creative Commons License specified pre-conditions.                    Exchange Consortium
                         Right of use on conditions encouraging
                         cooperation and further development,
Biological Open Source   instead of royalties or other conditions
License                  that discourage creation of products.        BiOS
                         Researchers from various organizations
                         controlling critical patents agree to the
Patent Pool              formation of a patent pool.                  Knockout Mouse Project
                         Geographic-based restrictions with respect
Geographic-based License to patenting and licensing.                  MalariaGEN

                                             pharma partners                                  9
                                             open innovation in bioscience
Understanding the continuum
between open access and OI
        Community        Potentially chaotic                            OPEN ACCESS
          driven
                                             Off-limits in some            Burden of support
                     OS entities                                            on Community
                     have legs !              IT organisations
                                                                            (=no support?)
                       Community needs                        Free
                         A shared goal                                   Altruistic?


        Success dependent on                                         Agreed standards
                                     Quality                             essential
     Open collaboration and sharing essential


                                                                         Organisation
       Transactional collaboration: Give to Receive
                                                                             led
                      Fair pricing            Lead needs
 Burden of support                            Clear vision
   On IP holder         model
                                                     Controlled by
OPEN INNOVATION                                        IP holder


                               pharma partners                                                 10
                                   open innovation in bioscience
A Note on IP Management
• The greatest open innovation success stories
  are non-exclusively licensed
  – ARM holdings (Open Innovation)
     • 98% of mobile phones use at least one ARM processor
  – Android smartphone OS (Open source)
     • Jan 2011 – 300,000 Android handsets activated daily

• OI is about proactive IP management
  – Strategy depends on your competitive viewpoint
     • Create and control strategic know-how and IP
     • Make available non-strategic know-how and IP

                          pharma partners                    11
                           open innovation in bioscience
2. What Open Innovation can mean
        for you (Jackie)

• Case studies– 10 mins
• Personal reflection – 10 mins
• Feedback and discussion – 10 mins




                  pharma partners                  12
                   open innovation in bioscience
Open innovation can have
             measurable impact
        Procter & Gamble –
                                                       BT – Open Innovation Principles
         Connect + Develop
“It was clear to us that our invent-             “[We will] use external sources to
it-ourselves model was not capable               multiply our own innovation efforts,
of sustaining high levels of top-line            deliver growth, reduce costs and get
growth” – P&G CEO AG Lafley                      to market faster” – BT’s ambition
                                                 statement
                                                   • 17 people are actively licensing
 • 50% of initiatives in product                     BT technology to external
   development have key elements                     companies, promoted on BT.com
   discovered or developed                         • 5-10 technology scouts claim to
   externally                                        have contributed £500 million to
 • R&D productivity increased 60%                    BT business plans through
 • Innovation success rate doubled                   innovative products and services
                                                     since 2002

                                   pharma partners                                       13
                                    open innovation in bioscience
Open Innovation can happen
       anywhere along the value chain
    external ecosystem: start-ups, universities, customers, suppliers…

                        ‘Beta
                        testing’ and          Crowd                    Partnership        Corporate
External   Problem      getting               sourcing/                program with       investment
           solving      feedback              idea                     start-ups and      fund
                                              generation               entrepreneurs


 Mix

                        ‘Beta
Internal                testing’              Crowd                    Intrapreneurship    Spin-Offs /
           Problem      and getting           sourcing/                program             Licensing
           solving      feedback              idea
                                              generation



                                       pharma partners                                          14
                                       open innovation in bioscience
Android: an open innovation
In the Red        success     In the Blue Corner
Corner
                                                                   iPHONE:
ANDROID:                                                   Closed Innovation
Open Source
Open Innovation




                                                      15



                      pharma partners
                      open innovation in bioscience
iPhone V Android :
Share of Smartphone Internet Usage (Apr 08 - Feb 10)




       JAN 2011 – 300,000 Android handsets activated daily
                          pharma partners                    16
                           open innovation in bioscience
Lego reinvents itself
Mindstorms

Architecture

Bricks and paper

Cuusoo
  1 p lac e: Shinkai
   .                   2. p lac e: Piano   3. p lac e: Pop -b and




  Votes: 1182          Votes: 342          Votes: 178




                                           pharma partners                   17
                                             open innovation in bioscience
Philips Innovation and business
ecosystem: High Tech Campus


     Corporate innovators               Research institutes
     Start-up companies                           Universities




      Technical services                  Network organizations
      Business support                                 Venture funds




                      pharma partners                                  18
                       open innovation in bioscience
Philips seen as a leader in OI
• Best practice in Inside–Out OI
  – in making IP work harder for Philips & others
  – in incubation, venturing, attracting investment
  – in creating High Tech Campus Eindhoven, NL
• Extensive network of academic and clinical
  research relationships
• Long-lasting engagement in public/private
  partnerships
• Promising examples of Outside-In OI

                         pharma partners                 19
                         open innovation in bioscience
Unilever’s open innovation
Supplier   University/      JV’s     Science Parks                      Scouting    Unilever   NGO’s
Networks    Contract     Alliances                                      Networks   Corporate
           Research                                                                Ventures




                                     Entrepreneurs




                                       pharma partners                                          20
                                        open innovation in bioscience
DSM is another OI advocate

• Interesting business option
  recognised by DSM
• Not fit within internal business
  strategy
• Founded in 2008 with DSM IP and
  external funding
• Reduced risk by available know-how
  and people
• Fast market introduction
• Delivering colour and flavouring to
  food and beverage customers



                           pharma partners                  21
                            open innovation in bioscience
GSK Consumer Health
• Embraces OI across the pipeline
• See growth arising from a number
  of areas:
  – Ingredients
  – Products
  – Packs
  – Processes
  – Claims
  – Routes to market
  – Regulatory compliance
• Publicising what they need and want
• Maclaren Alliance

                            pharma partners                 22
                            open innovation in bioscience
GSK Consumer: ENIGMA launch
       event (Sept 2007)
ENIGMA: External networking and innovation groups
for market advantage
 75 external organisations
  – Ingredient & packaging suppliers
  – Research associations & institutes
  – Development organisations
  – Process equipment manufacturers
  – Environmental companies
  – Academic institutions
  – Consultants & inventors
  – Competitors & industry representatives
Q & A session, networking, mingling, conversations

                         pharma partners                  23
                          open innovation in bioscience
ENIGMA Think Tank 2009

• 2 key technical challenges identified by brand/R&D teams
• Brought together scientific experts to creatively explore
  issues
• 24 organisations attended – academia & industry contacts
• Plus innovation experts from OUTSIDE food & drink
• 6 GSK facilitators from R&D, Marketing & Procurement
• Brainstorming type activities to stimulate creative
  thinking
• Several potential areas identified for further
  investigation




                           pharma partners                  24
                            open innovation in bioscience
Questions for reflection

– How could OI be relevant to my business?

– What are the barriers?

– What are the potential next steps for
  implementing OI?




                  pharma partners                  25
                   open innovation in bioscience
3. Different perspectives on OI
             (Jackie)
• How OI differs between large and small
  companies
• OI from the perspectives of both the
  innovation provider and consumer
• Barriers and enablers




                  pharma partners                 26
                  open innovation in bioscience
Large vs small

Large company                      Small company
• People - more                    • Entrepreneurial, risk
  conservative; less risk            takers
  taking
• Medium time horizons             • Short term
• Decision making by               • Rapid decision making
  committee
• Financially secure               • Financial urgency
• Portfolio of projects            • Focus on single
  and collaborations                 projects
• Standard process for             • Flexible processes
  partnering
                        pharma partners                      27
                        open innovation in bioscience
Large vs small

Large company                         Small company
• Usually lot of support              • Little or no support
  eg IP, legal, alliance                internally for
  management                            collaborations
• Lot of experience in                • Limited experience in
  partnering                            partnering
• Range of capabilities               • Limited capabilities in
  in house                              house
• Broad range of IP                   • Limited IP


                           pharma partners                    28
                           open innovation in bioscience
Need to recognise different
           perspectives
• Balance between separate and shared
  interests

• Maximise outcome and value creation
  for each party whilst minimising risk




                   pharma partners                 29
                   open innovation in bioscience
Collaboration Exercise
One half of room                             Other half of room
• Work in pairs                              • Work in pairs
   – First half of session pair                          – First half of session pair
     member 1 is large                                     member 1 is innovation
     corporate partner and                                 provider and member 2 is
     member 2 is                                           consumer
     academic/SME
   – Reverse roles for second                            – Reverse roles for second
     half                                                  half
   – Present what you offer,                             – Present what you offer,
     how is it perceived, what                             how is it perceived, what
     are the expectations and                              are the expectations and
     barriers for each party                               barriers for each party
• Plenary discussion on                      • Plenary discussion on
  lessons learned                              lessons learned


                                  pharma partners                                   30
                                  open innovation in bioscience
4. The Ideal OI Ecosystem (Mike)




              pharma partners                 31
              open innovation in bioscience
The Selfish Scientist
“A biologist would rather share their
toothbrush than their (gene) names”
                                                         Michael Ashburner
                                                         Professor Genetics
                                                    University of Cambridge
                                                                         UK




                   Why should scientists cooperate?

                   pharma partners                                     32
                    open innovation in bioscience
The Prisoner’s Dilemma
 Eachprisoners’ best strategy
 regardless of the others’ is dominant.
      The   dominant strategy is to defect                                   Prisoner B
 Prisoners could do better by both
 staying silent                                        Silent (Cooperate)          Confess (Defect)
      but once collusion sets in, each
       prisoner has an incentive to cheat!
 The logical strategy is not always best


                      Silent (Cooperate) Each get 1 years A gets 15 yrs
                                                                                   B goes free
Prisoner A
                      Confess (Defect)                 A goes free                 Each get 3 years
                                                       B gets 15 yrs



                                             pharma partners                                     33
                                              open innovation in bioscience
THE R&D Game: A Dominant Strategy
• The Nappy Industry Oligopoly
  – A perfect fit for the prisoners dilemma
      Proctor & Gamble                                   Kimberley-Clark




                              v
                     pharma partners                                       34
                         open innovation in bioscience
THE R&D Game: A Dominant Strategy
Dominant strategy for both firms is
to undertake the R&D. If one defects
the other will lose market share               Proctor & Gamble
But both firms spending on R&D may
yield a lower total return than if both        R&D investment         No R&D
firms resist the temptation                                           Investment
Factors other than profits are also
important
                 R&D Investment                (+$5m, +$45m)          (+$85m, -$10m)
 Kimberly-
   Clark
                 No R&D                        (-$10m, +£85m))        (+$30m, +$70m)
                 Investment                                            What about Open
                                                                       Access R&D?


                                     pharma partners                               35
                                      open innovation in bioscience
Reaching Equilibrium:
                Open Access R&D
Closed                                                  Open Access
 R&D                                                       R&D


 Strong R&D                                               Altruism, etc
   budgets
 Low hanging
    fruit
High Predicted
  Revenues




                                                        That Was Then.....
                       pharma partners                                    36
                        open innovation in bioscience
Reaching Equilibrium:
              Open Access R&D
Closed                                                    Open Access
 R&D                                                         R&D
                  Cultural Change
                                                            Lack of disease
 Weak R&D                                                   Understanding
  Budgets
 Uncertain                                                  Payer pressure
 revenues
                                                            Perceived Risk




                                                          Is this now?....
                         pharma partners                                      37
                          open innovation in bioscience
An Open Innovation Ecosystem




            pharma partners                 38
            open innovation in bioscience
Players in the OI Ecosystem
                                                                           Tertiary Innovator
                                                                           • Innovation super-consumer
                                                                           • Industry and large SME
Secondary Innovator                                                        • Multidisciplinary
• Translational powerhouse                                                 • Highly networked
• Industry, SME                                                            • Tech-transfer and In-licensing
• May be resistant to change                                               • May seek exclusivity
• Domain expert                                                            • Change agent
• Good network                                                             • Outlicensing
• Makes tech transfer work
• Publicises needs (Crowdsourcing)
• Partner with 1° Innovator
                                     Primary Innovator
                                     • Innovation powerhouse
                                     • Academia, SME
                                     • Specialist
                                     • Close partnership with 2° innovator
                                     • Avoid exclusive licensing
                                     • Needs good understanding of
                                       business reqs. of 2° & 3° Innovators

                                          pharma partners                                              39
                                           open innovation in bioscience
An Open Innovation Ecosystem
Exclusively Internal IP                                         Proprietary research
& Knowledge                                                        is key: but needs
                                  Closed                       to be highly strategic
Single/Few                      Innovation
Partner                                                                    These are the
Relationships                Open Innovation                                  foundation
                               (Under CDA,                                   but require
                              shared IP etc)
Many                                                                             cultural
Partners                                                                          change
                              Open Access
Open
Sharing
                            Open Standards


                      Public Domain Data Generation


                               pharma partners                                          40
                               open innovation in bioscience
Discussion over lunch (Mike)

• What might you do as next steps within /
  outside your organisations to implement
  OI as a strategy to create more value
• Slides from today available on our website

          http://www.oipharmapartners.com
             info@oipharmapartners.com
              Tel. +44 (0) 7879 694 253




                       pharma partners                 41
                       open innovation in bioscience

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Open Innovation primer - OI pharma partners workshop

  • 1. OPEN INNOVATION – a primer An interactive workshop bringing insights from the life science and IT sectors Jackie Hunter, Elisabeth Goodman, Michael Barnes - OI Pharma Partners Granta Park, Cambridge, 11 Nov 2011 (#OICambs11Nov) pharma partners 1 open innovation in bioscience
  • 2. Goals for today 1. Dispel some of the hype that surrounds open innovation 2. Explore key themes – Take a practical approach – Mix of presentations, break-out exercises, case studies and discussion pharma partners 2 open innovation in bioscience
  • 3. A little background on OI Pharma Partners • Founded in 2010 by Dr Jackie Hunter • Focus on adding value to Healthcare industries by realising the power of Open Innovation – Working with life science and healthcare companies on OI strategy and implementation – Developing OI in Healthcare strategy with EU Cyprus presidency – Member of OI consortia • What we offer*: – Strategy – diagnosis, and development – Implementation – accessing networks / partners, best practices in collaborative project management – Intermediary – IP brokering, novel ideas / technologies Combined with scientific expertise.. pharma partners *see flyer for more details 3 open innovation in bioscience
  • 4. Topics for today (broad timings) 09:30 – 09:45 Introduction (Louise Rushworth, Elisabeth Goodman) 09:45 – 10:15 What is meant by Open Innovation (Mike Barnes) 10:15 – 10:45 What Open Innovation can mean for you (Jackie Hunter) 10:45 – 11:30 How OI differs between large and small organisations, providers and consumers: barriers & enablers (Jackie Hunter) 11:30 – 12:00 The ideal OI Ecosystem (Mike Barnes) 12:00 – 13:00 Discussions over lunch: What participants might do as next steps within / outside their organisations to implement OI as a strategy to create more value pharma partners 4 open innovation in bioscience
  • 5. 1. What is meant by OI? What are the key principles? (Mike) • Do we have the same understanding? Flip chart exercise pharma partners 5 open innovation in bioscience
  • 6. “The lab is my world” “The world is my lab” A mindset based on trust Dare to share future profits (or losses) pharma partners 6 open innovation in bioscience
  • 7. The Innovation Continuum Internal R&D pharma partners 7 open innovation in bioscience
  • 8. More than one model for Open Innovation OPEN INNOVATION COMPETITIVE: IP Model PRE-COMPETITIVE: Open Access Model pharma partners 8 open innovation in bioscience
  • 9. IP strategies used in Healthcare IP Strategy Description Examples Rapid release of data into public databases; Human Genome; Open Access Open Data Access sometimes with an embargo period journals, Chembl, Arch2POCM Non-exclusive, royalty-free licenses; Not Open BioSystems; Biomarkers Non-exclusive License commercially exploitable. Consortium licenses that enable researchers to keep their copyright but allow others to copy and distribute the work provided that credit is assigned in accordance with International Molecular Creative Commons License specified pre-conditions. Exchange Consortium Right of use on conditions encouraging cooperation and further development, Biological Open Source instead of royalties or other conditions License that discourage creation of products. BiOS Researchers from various organizations controlling critical patents agree to the Patent Pool formation of a patent pool. Knockout Mouse Project Geographic-based restrictions with respect Geographic-based License to patenting and licensing. MalariaGEN pharma partners 9 open innovation in bioscience
  • 10. Understanding the continuum between open access and OI Community Potentially chaotic OPEN ACCESS driven Off-limits in some Burden of support OS entities on Community have legs ! IT organisations (=no support?) Community needs Free A shared goal Altruistic? Success dependent on Agreed standards Quality essential Open collaboration and sharing essential Organisation Transactional collaboration: Give to Receive led Fair pricing Lead needs Burden of support Clear vision On IP holder model Controlled by OPEN INNOVATION IP holder pharma partners 10 open innovation in bioscience
  • 11. A Note on IP Management • The greatest open innovation success stories are non-exclusively licensed – ARM holdings (Open Innovation) • 98% of mobile phones use at least one ARM processor – Android smartphone OS (Open source) • Jan 2011 – 300,000 Android handsets activated daily • OI is about proactive IP management – Strategy depends on your competitive viewpoint • Create and control strategic know-how and IP • Make available non-strategic know-how and IP pharma partners 11 open innovation in bioscience
  • 12. 2. What Open Innovation can mean for you (Jackie) • Case studies– 10 mins • Personal reflection – 10 mins • Feedback and discussion – 10 mins pharma partners 12 open innovation in bioscience
  • 13. Open innovation can have measurable impact Procter & Gamble – BT – Open Innovation Principles Connect + Develop “It was clear to us that our invent- “[We will] use external sources to it-ourselves model was not capable multiply our own innovation efforts, of sustaining high levels of top-line deliver growth, reduce costs and get growth” – P&G CEO AG Lafley to market faster” – BT’s ambition statement • 17 people are actively licensing • 50% of initiatives in product BT technology to external development have key elements companies, promoted on BT.com discovered or developed • 5-10 technology scouts claim to externally have contributed £500 million to • R&D productivity increased 60% BT business plans through • Innovation success rate doubled innovative products and services since 2002 pharma partners 13 open innovation in bioscience
  • 14. Open Innovation can happen anywhere along the value chain external ecosystem: start-ups, universities, customers, suppliers… ‘Beta testing’ and Crowd Partnership Corporate External Problem getting sourcing/ program with investment solving feedback idea start-ups and fund generation entrepreneurs Mix ‘Beta Internal testing’ Crowd Intrapreneurship Spin-Offs / Problem and getting sourcing/ program Licensing solving feedback idea generation pharma partners 14 open innovation in bioscience
  • 15. Android: an open innovation In the Red success In the Blue Corner Corner iPHONE: ANDROID: Closed Innovation Open Source Open Innovation 15 pharma partners open innovation in bioscience
  • 16. iPhone V Android : Share of Smartphone Internet Usage (Apr 08 - Feb 10) JAN 2011 – 300,000 Android handsets activated daily pharma partners 16 open innovation in bioscience
  • 17. Lego reinvents itself Mindstorms Architecture Bricks and paper Cuusoo 1 p lac e: Shinkai . 2. p lac e: Piano 3. p lac e: Pop -b and Votes: 1182 Votes: 342 Votes: 178 pharma partners 17 open innovation in bioscience
  • 18. Philips Innovation and business ecosystem: High Tech Campus Corporate innovators Research institutes Start-up companies Universities Technical services Network organizations Business support Venture funds pharma partners 18 open innovation in bioscience
  • 19. Philips seen as a leader in OI • Best practice in Inside–Out OI – in making IP work harder for Philips & others – in incubation, venturing, attracting investment – in creating High Tech Campus Eindhoven, NL • Extensive network of academic and clinical research relationships • Long-lasting engagement in public/private partnerships • Promising examples of Outside-In OI pharma partners 19 open innovation in bioscience
  • 20. Unilever’s open innovation Supplier University/ JV’s Science Parks Scouting Unilever NGO’s Networks Contract Alliances Networks Corporate Research Ventures Entrepreneurs pharma partners 20 open innovation in bioscience
  • 21. DSM is another OI advocate • Interesting business option recognised by DSM • Not fit within internal business strategy • Founded in 2008 with DSM IP and external funding • Reduced risk by available know-how and people • Fast market introduction • Delivering colour and flavouring to food and beverage customers pharma partners 21 open innovation in bioscience
  • 22. GSK Consumer Health • Embraces OI across the pipeline • See growth arising from a number of areas: – Ingredients – Products – Packs – Processes – Claims – Routes to market – Regulatory compliance • Publicising what they need and want • Maclaren Alliance pharma partners 22 open innovation in bioscience
  • 23. GSK Consumer: ENIGMA launch event (Sept 2007) ENIGMA: External networking and innovation groups for market advantage 75 external organisations – Ingredient & packaging suppliers – Research associations & institutes – Development organisations – Process equipment manufacturers – Environmental companies – Academic institutions – Consultants & inventors – Competitors & industry representatives Q & A session, networking, mingling, conversations pharma partners 23 open innovation in bioscience
  • 24. ENIGMA Think Tank 2009 • 2 key technical challenges identified by brand/R&D teams • Brought together scientific experts to creatively explore issues • 24 organisations attended – academia & industry contacts • Plus innovation experts from OUTSIDE food & drink • 6 GSK facilitators from R&D, Marketing & Procurement • Brainstorming type activities to stimulate creative thinking • Several potential areas identified for further investigation pharma partners 24 open innovation in bioscience
  • 25. Questions for reflection – How could OI be relevant to my business? – What are the barriers? – What are the potential next steps for implementing OI? pharma partners 25 open innovation in bioscience
  • 26. 3. Different perspectives on OI (Jackie) • How OI differs between large and small companies • OI from the perspectives of both the innovation provider and consumer • Barriers and enablers pharma partners 26 open innovation in bioscience
  • 27. Large vs small Large company Small company • People - more • Entrepreneurial, risk conservative; less risk takers taking • Medium time horizons • Short term • Decision making by • Rapid decision making committee • Financially secure • Financial urgency • Portfolio of projects • Focus on single and collaborations projects • Standard process for • Flexible processes partnering pharma partners 27 open innovation in bioscience
  • 28. Large vs small Large company Small company • Usually lot of support • Little or no support eg IP, legal, alliance internally for management collaborations • Lot of experience in • Limited experience in partnering partnering • Range of capabilities • Limited capabilities in in house house • Broad range of IP • Limited IP pharma partners 28 open innovation in bioscience
  • 29. Need to recognise different perspectives • Balance between separate and shared interests • Maximise outcome and value creation for each party whilst minimising risk pharma partners 29 open innovation in bioscience
  • 30. Collaboration Exercise One half of room Other half of room • Work in pairs • Work in pairs – First half of session pair – First half of session pair member 1 is large member 1 is innovation corporate partner and provider and member 2 is member 2 is consumer academic/SME – Reverse roles for second – Reverse roles for second half half – Present what you offer, – Present what you offer, how is it perceived, what how is it perceived, what are the expectations and are the expectations and barriers for each party barriers for each party • Plenary discussion on • Plenary discussion on lessons learned lessons learned pharma partners 30 open innovation in bioscience
  • 31. 4. The Ideal OI Ecosystem (Mike) pharma partners 31 open innovation in bioscience
  • 32. The Selfish Scientist “A biologist would rather share their toothbrush than their (gene) names” Michael Ashburner Professor Genetics University of Cambridge UK Why should scientists cooperate? pharma partners 32 open innovation in bioscience
  • 33. The Prisoner’s Dilemma  Eachprisoners’ best strategy regardless of the others’ is dominant.  The dominant strategy is to defect Prisoner B  Prisoners could do better by both staying silent Silent (Cooperate) Confess (Defect)  but once collusion sets in, each prisoner has an incentive to cheat!  The logical strategy is not always best Silent (Cooperate) Each get 1 years A gets 15 yrs B goes free Prisoner A Confess (Defect) A goes free Each get 3 years B gets 15 yrs pharma partners 33 open innovation in bioscience
  • 34. THE R&D Game: A Dominant Strategy • The Nappy Industry Oligopoly – A perfect fit for the prisoners dilemma Proctor & Gamble Kimberley-Clark v pharma partners 34 open innovation in bioscience
  • 35. THE R&D Game: A Dominant Strategy Dominant strategy for both firms is to undertake the R&D. If one defects the other will lose market share Proctor & Gamble But both firms spending on R&D may yield a lower total return than if both R&D investment No R&D firms resist the temptation Investment Factors other than profits are also important R&D Investment (+$5m, +$45m) (+$85m, -$10m) Kimberly- Clark No R&D (-$10m, +£85m)) (+$30m, +$70m) Investment What about Open Access R&D? pharma partners 35 open innovation in bioscience
  • 36. Reaching Equilibrium: Open Access R&D Closed Open Access R&D R&D Strong R&D Altruism, etc budgets Low hanging fruit High Predicted Revenues That Was Then..... pharma partners 36 open innovation in bioscience
  • 37. Reaching Equilibrium: Open Access R&D Closed Open Access R&D R&D Cultural Change Lack of disease Weak R&D Understanding Budgets Uncertain Payer pressure revenues Perceived Risk Is this now?.... pharma partners 37 open innovation in bioscience
  • 38. An Open Innovation Ecosystem pharma partners 38 open innovation in bioscience
  • 39. Players in the OI Ecosystem Tertiary Innovator • Innovation super-consumer • Industry and large SME Secondary Innovator • Multidisciplinary • Translational powerhouse • Highly networked • Industry, SME • Tech-transfer and In-licensing • May be resistant to change • May seek exclusivity • Domain expert • Change agent • Good network • Outlicensing • Makes tech transfer work • Publicises needs (Crowdsourcing) • Partner with 1° Innovator Primary Innovator • Innovation powerhouse • Academia, SME • Specialist • Close partnership with 2° innovator • Avoid exclusive licensing • Needs good understanding of business reqs. of 2° & 3° Innovators pharma partners 39 open innovation in bioscience
  • 40. An Open Innovation Ecosystem Exclusively Internal IP Proprietary research & Knowledge is key: but needs Closed to be highly strategic Single/Few Innovation Partner These are the Relationships Open Innovation foundation (Under CDA, but require shared IP etc) Many cultural Partners change Open Access Open Sharing Open Standards Public Domain Data Generation pharma partners 40 open innovation in bioscience
  • 41. Discussion over lunch (Mike) • What might you do as next steps within / outside your organisations to implement OI as a strategy to create more value • Slides from today available on our website http://www.oipharmapartners.com info@oipharmapartners.com Tel. +44 (0) 7879 694 253 pharma partners 41 open innovation in bioscience