Calcium hydroxide (Ca(OH)2) extrusion during endodontic treatment can induce tissue reactions, ranging from minor inflammation to serious complications like necrosis and paresthesia. While typically tolerated, its high initial toxicity can lead to adverse effects on surrounding tissues, prompting the need for careful management to avoid extrusion. Recommendations for prevention and management include assessing radiographs, careful injection techniques, and thorough documentation in case complications arise.