Cells are the basic structural and functional units of all living organisms. Robert Hooke first observed cells in 1665 when examining cork under a microscope. Cells come in a variety of shapes and sizes, and can be either prokaryotic (unicellular) or eukaryotic (multicellular). All cells contain a nucleus surrounded by cytoplasm and are enclosed by a cell membrane. In plant cells, a cell wall also surrounds the cell membrane providing structure and protection. Organisms are made of tissues, tissues make up organs, and cells are the basic units that tissues are made of.